A5100320128- DNA and Nucleic Acid Chemistry
- Mass Spectrometry Techniques and Applications
- Radical Photochemical Reactions
- Photochemistry and Electron Transfer Studies
- Influenza Virus Research Studies
- Ophthalmology and Visual Impairment Studies
- Catalytic C–H Functionalization Methods
- Corneal surgery and disorders
- Quantum Dots Synthesis And Properties
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- Perovskite Materials and Applications
- Respiratory viral infections research
- Analytical Chemistry and Chromatography
- Liver Disease Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Chemical Synthesis and Analysis
- Pharmacological Effects and Assays
- Sulfur-Based Synthesis Techniques
- Monoclonal and Polyclonal Antibodies Research
- Pneumonia and Respiratory Infections
- Receptor Mechanisms and Signaling
- Advanced Chemical Physics Studies
- Chalcogenide Semiconductor Thin Films
- Technology and Security Systems
Johns Hopkins University
2025
University of Science and Technology of China
2014-2024
Beijing Institute of Technology
2024
Anhui University
2023-2024
Chinese Academy of Sciences
2011-2024
Hefei Institutes of Physical Science
2023-2024
University of Washington
2018-2023
Fuzhou University
2023
Jiangnan University
2022
Shanxi Medical University
2022
The 2009 H1N1 influenza pandemic (pH1N1) led to record sales of neuraminidase (NA) inhibitors, which has contributed significantly the recent increase in oseltamivir-resistant viruses. Therefore, development and careful evaluation novel NA inhibitors is great interest. Recently, a highly potent inhibitor, laninamivir, been approved for use Japan. Laninamivir effective using single inhaled dose via its octanoate prodrug (CS-8958) demonstrated be against vitro. However, effectiveness...
To characterize the effects on refractive error development and eye growth in young chicks of two-zone concentric lens designs, which differentially affect defocus experiences central peripheral retinal regions.Monocular defocusing lenses were worn for 5 days from 17 age. Four designs (overall optical zone diameter, 10 mm) combining plano with either -5- or +5-D power used. Lens as follows: (1) +5 D center (+5C), (2) periphery (+5P), (3) -5 (-5C), (4) (-5P), all C-designs P-designs. Five...
Increased intake of whole grain and dietary fiber has been associated with lower risk insulin resistance, hyperinsulinemia, inflammation, which are known predisposing factors for hepatocellular carcinoma (HCC). Therefore, we hypothesized that long-term grains may be HCC.To assess the associations HCC.Cohort study grains, their subcomponents (bran germ), (cereal, fruit, vegetable) in 125 455 participants from 2 cohorts Nurses' Health Study Professionals Follow-up Study.Intake were collected...
We investigated the effects on refractive development and ocular growth of 2-zone concentric lenses with different negative powers in each optical zones, normal myopic eyes young chicks.Monocular defocusing were worn for 10-15 days from 12 age. Two lens types combining -5 -10 diopter (D) powers, center zone diameters ranging 4.5-7.5 mm tested. One group chickens wore age 10 days, without any previous treatment. A second 12-day-old treated initially D single vision (SV) 5 to induce myopia,...
Drug-resistant microbes pose a global health concern, requiring the urgent development of effective antibacterial agents and strategies in clinical practice. Therefore, there is an need to explore novel materials effectively eliminate bacteria. The synthesis quaternary phosphonium salt haloargentate systems, wherein phosphorus atom represented cationic form, possible strategy for materials. Using (triphenyl)phosphonium-based salts with different spacer lengths (n=2, 4, 6) as template, we...
There are 9 serotypes of neuraminidase (NA) from influenza A virus (N1 to N9), which classified into two groups based on primary sequences (groups 1 and 2). The structural hallmark the is presence or absence an extra 150-cavity (formed by 150-loop) in active site. Thus far, structures NAs 6 out have been solved. Here, we solved N5 structure, last unknown structure group serotype with a unique Asn147 residue its 150-loop, demonstrating that it has extended closes upon inhibitor binding.
A novel strategy of cascade radical C(sp2/sp3)–S bond cleavage and group-transfer cyclization is disclosed. Triggered by alkyl radicals, varieties 2-isocyanoaryl thioethers containing aliphatic, aryl, heteroaromatic groups can be cleaved precisely reinstalled to give benzothiazole derivatives. Mechanistic studies reveal that the reaction undertakes an intermolecular pathway, inner sources (R radicals) exhibit high priority over those methyl origin from di-tert-butyl peroxide.
In previous reports of the literature, ZnO nanoparticles were unexceptionally used as electron transportation material in highly efficient CdSe-based quantum dot light-emitting diodes (QD-LEDs). However, an amphoteric oxide, are chemically unstable air. Here, we utilize quantum-sized SnO2 layer (ETL) QD-LEDs. Decreasing size will upshift conduction band from -4.50 to -3.84 eV based on effect, which is beneficial facilitate injection into QD emitting layer. Our investigations show that...
Abstract Herein, the development of a visible‐light‐induced catalytic system to achieve decarboxylative acylation pyridine N ‐oxides with α‐oxocarboxylic acids, at room temperature and using organic dye fluorescein dimethylammonium as new type photocatalyst, is reported. A series 2‐arylacylpyridine were selectively synthesized in moderate good yields by controlling polarity reaction solvent. The developed strategy was successfully applied synthesis an important intermediate drug,...
Cation radicals of guanine (G•+), 9-methylguanine (MG•+), and guanosine (rG•+) were generated by dissociative oxidation gas-phase copper complexes characterized UV–vis photodissociation action spectra ab initio calculations. Comparison the G•+ with calculated vibronic absorption several cation radical tautomers showed best match for canonical 6-oxo-N-9-H structure (G1•+). The formation G1•+ was favored stability its precursor CuII ion in solution gas phase. marginally lowest-energy tautomer...
Two new reaction processes involving the in situ oxidative photochemical conversion of CHCl3 to COCl2 allowed selective syntheses N-substituted ureas and isocyanates from amines. (I) A solution containing an amine organic base under O2 bubbling provided urea derivative exposure UV light generated a low-pressure mercury lamp at 20-40 °C. (II) two-step photodecomposition lower temperatures subsequent sequential injections into sample isocyanate high yield. The capitalize on conditions [COCl2]...
Antihypertensive medications have been investigated in relation to colorectal cancer (CRC)-specific survival. To address limitations and important unanswered questions the existing evidence, we associations of pre- post-diagnostic use antihypertensive classes-beta-blockers, calcium channel blockers, thiazide diuretics, angiotensin-converting enzyme inhibitors, furosemide, other antihypertensives-with CRC-specific mortality among 2,182 patients with stage I-III CRC Nurses' Health Study...
Abstract Eight eudesmane‐type sesquiterpenes – phaeusmanes A–H ( 1 8 ) isolated for the first time in this work, and four others 9 12 from plants together with fourteen known eudesmane derivatives, were rhizomes of Curcuma phaeocaulis . Their structures elucidated by 1D 2D NMR CD spectroscopy HRMS. Compound is example a nitrogen‐containing sesquiterpene genus Furthermore, inhibitory effects compounds on NO production lipopolysaccharide‐activated macrophages evaluated. Compounds , 6 10 19 22...
Adenosine radicals tagged with a fixed-charge group were generated in the gas phase and structurally characterized by tandem mass spectrometry, deuterium labeling, UV/Vis action spectroscopy. Experimental results combination Born-Oppenheimer molecular dynamics, ab initio, excited-state calculations led to unambiguous assignment of adenosine as N-7 hydrogen atom adducts. The charge-tagged found be electronically equivalent natural DNA nucleoside radicals.
Peanut (also called groundnut, Arachis hypogaea L.) seeds are used for producing edible oils and functional foods, offer a rich source of lipids, proteins carbohydrates. However, the location these metabolites has not yet been firmly established. In present study, matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI-MSI) technique was applied to investigate spatial distribution lipids other key components in three peanut cultivars (ZH9, KQBH, HP). A total 103...
Though rapid tests were developed for mass screening of prion diseases in the last century, bovine spongiform encephalopathy (BSE) was still epidemic some European countries. The main reason is that sensitivity such insufficient detecting animals are incubating with at presymptomatic stage. Driven by this, this contribution, we a novel sensitive label-free method taking advantage DNA aptamer proteins (PrP) detection through formation T-Hg(2+)-T configuration. In presence Hg(2+) ions,...
More and more evidence shows that microbes play crucial roles in human health disease. The exploration of the relationship between diseases will help people to better understand underlying pathogenesis have important implications for disease diagnosis prevention. However, known associations are very less. We proposed a new method called non-negative matrix factorization microbe-disease (NMFMDA), which used Gaussian interaction profile kernel similarity measure, calculate microbial...