A5044417934- High Altitude and Hypoxia
- Cardiac Ischemia and Reperfusion
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Neuroscience of respiration and sleep
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Neuroendocrine regulation and behavior
- Animal Virus Infections Studies
- Heart Rate Variability and Autonomic Control
- Anesthesia and Neurotoxicity Research
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Nitric Oxide and Endothelin Effects
- Cardiac Arrest and Resuscitation
- Sirtuins and Resveratrol in Medicine
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Heme Oxygenase-1 and Carbon Monoxide
- Renin-Angiotensin System Studies
- Cardiovascular Disease and Adiposity
- Eicosanoids and Hypertension Pharmacology
Hebei Medical University
2015-2025
Ministry of Education of the People's Republic of China
2025
Henan University of Science and Technology
2025
Nanjing Forestry University
2025
Sichuan Cancer Hospital
2024
University of Electronic Science and Technology of China
2024
Chongqing University
2023
Hospital of Hebei Province
2023
Anhui Agricultural University
2023
Center for Innovation
2023
Background and Purpose— Glutamate NMDARs (N-methyl- D -aspartate receptors) play a major role in the initiation of ischemic brain damage. However, NMDAR antagonists have no protective effects stroke patients, possibly because they impair physiological functions NMDARs. α2δ-1 (encoded by Cacna2d1 ) is strongly expressed many regions. We determined contribution to hyperactivity injury induced ischemia reperfusion. Methods— Mice were subjected 90 minutes middle cerebral artery occlusion...
Seventy-eight isolates of avian infectious bronchitis virus (IBV) were obtained from different field outbreaks in China 2009 and genotyped with 34 reference strains. Four genotypes IBV three new identified by phylogenetic analysis BLAST searches the entire S1 gene. The results showed that most strains have circulated recent years belong to genotype QX-like strains, they could be grouped further into two clusters, regardless level genetic variation displayed. A study pathogenicity used...
Both the sympathetic nervous system and renin-angiotensin are critically involved in hypertension development. Although angiotensin II (Ang II) stimulates hypothalamic paraventricular nucleus (PVN) neurons to increase vasomotor tone, molecular mechanism mediating this action remains unclear. The glutamate NMDAR PVN controls outflow hypertension. In study, we determined interaction between α2δ-1 (encoded by Cacna2d1), commonly known as a Ca2+ channel subunit, NMDARs hypothalamus its role Ang...
Abstract Vesicular glutamate transporter‐2 ( VG luT2) mediates the uptake of into synaptic vesicles in neurons. Spinal cord dorsal horn interneurons are highly heterogeneous and molecularly diverse. The functional significance luT2‐expressing neurons physiological pathological pain conditions has not been explicitly demonstrated. Designer receptors exclusively activated by designer drugs DREADD s) a powerful chemogenetic tool to reversibly control neuronal excitability behavior. Here, we...
Diabetic retinopathy (DR) is a microvascular complication of diabetes. The retinal pigment epithelium (RPE) forms the outer layer blood‑retinal barrier and serves role in maintaining function. RPE cell injury has been revealed diabetic animal models, high glucose (HG) levels may cause damage to cells by increasing oxidative stress, promoting pro‑inflammatory gene expression, disrupting proliferation, inducing endothelial‑mesenchymal transition, weakening tight conjunctions elevating death...
Naringenin (Nari) has antioxidative and anti-atherosclerosis effects, activation of ATP-sensitive potassium channel (KATP) can offer cardiac protection. We hypothesized that Nari protects the heart against ischemia-reperfusion (I-R) injury through KATP. Isolated hearts from adult male Sprague-Dawley rats experienced a 30-min global ischemia followed by 60-min reperfusion (120 min for infarct size determination). The were treated with (NARI); plus glibenclamide (GLI), non-specific blocker...
Key points α2δ‐1 is upregulated, promoting the interaction with NMDA receptors (NMDARs), in hypothalamus a rat model of hypertension. The prevalence α2δ‐1–bound NMDARs at synaptic sites increased hypertensive animals. essential for presynaptic and postsynaptic NMDAR activity hypothalamic neurons are critically involved augmented sympathetic outflow Abstract Increased glutamate receptor (NMDAR) paraventricular nucleus (PVN) leads to However, molecular mechanisms underlying this effect remain...
<title>Abstract</title> Coronary heart disease (CHD) is a severe diabetic vascular complication and the main cause of mortality among diabetes patients. Early diagnosis CHD could prevent its development. Both omentin-1 (Oment-1) long noncoding RNA MALAT1 (lncRNA MALAT1) can be detected in peripheral blood exhibit protective or detrimental effects on CHD. However, whether these two factors predictive T2DM patients remains unclear. Therefore, this study aimed to investigate associations...
High-performance fiber-braided composite tubular truss structures have been widely used in satellites due to their advantages, such as lightweight and thermal stability. The continuous braiding of yarns a multi-jointed preform is challenging because the complexity its joint structure. To realize process with constant number at joints, mathematical model for spindle motion trajectory was developed by intermittently segmenting track. Based on model, relationship between spindles units...
Fifty-six isolates of avian infectious bronchitis virus (IBV) were obtained from different field outbreaks in China 2010, and they genotyped by comparison with 19 reference strains the present study. The results showed that LX4-type are still predominant IBVs circulating chicken flocks China, these could be grouped further into two clusters. Viruses each cluster had favored amino acid residues at positions S1 subunit spike protein. In addition, a recombination event was observed to have...
Previous studies demonstrated that energy metabolism disturbance impairs cardiac function and chronic intermittent hypobaric hypoxia (CIHH) protects heart against ischemia/reperfusion injury. The present study aimed to test the hypothesis CIHH (I/R) injury via improvement of glucose metabolism.Male Sprague-Dawley rats received treatment simulating 5000-m altitude for 28 days, 6 h per day in a chamber or no (control). Body weight, fasting blood glucose, lipid tolerance were measured. left...
Key points The angiotensin AT1 receptor expression and protein kinase C (PKC)‐mediated NMDA phosphorylation levels in the hypothalamus are increased a rat genetic model of hypertension. Blocking receptors or PKC activity normalizes pre‐ postsynaptic hypothalamic presympathetic neurons hypertensive animals. Inhibition receptor–PKC reduces arterial blood pressure sympathetic nerve discharges endogenously activated to sustain hyperactivity elevated outflow via Abstract Increased synaptic N...
Purpose Fracture blister (FB) is a frequent complication in orthopedic surgery. The primary objective of this study was to refine the animal model FB and identify plasma protein markers associated with its development progression. Methods In study, Sprague-Dawley (SD) rats were used as experimental subjects. Various pressures compression durations applied lower limbs fractures compare differential expression patterns (DEPs) between pressure-time combination that resulted highest incidence...
Abstract Coronary heart disease (CHD) is a severe diabetic vascular complication and the main cause of mortality among diabetes patients. Early diagnosis CHD could prevent its development. Both omentin-1 (Oment-1) long noncoding RNA MALAT1 (lncRNA MALAT1) can be detected in peripheral blood exhibit protective or detrimental effects on CHD. However, whether these two factors predictive T2DM patients remains unclear. Therefore, this study aimed to investigate associations circulating Oment-1...
Chronic intermittent hypobaric hypoxia (CIHH) has an effective cardiac protection against ischemia-reperfusion injury. However, the underlying mechanisms are not fully known. It been shown that blockade of beta-adrenergic receptor exerts anti-arrhythmic action and improves remodeling in ischemic myocardium. Thus we determined influence CIHH on activity right ventricular papillary muscle rats. We found potential duration was significantly longer rats than control Activation with...