A5100416176- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Bone health and treatments
- Metabolism, Diabetes, and Cancer
- Circular RNAs in diseases
- FOXO transcription factor regulation
- Extracellular vesicles in disease
- GDF15 and Related Biomarkers
- Diabetes Treatment and Management
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- Nanoparticle-Based Drug Delivery
- Mesenchymal stem cell research
- Pediatric Hepatobiliary Diseases and Treatments
- Clusterin in disease pathology
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
- Muscle Physiology and Disorders
- Melanoma and MAPK Pathways
- Epigenetics and DNA Methylation
- Osteoarthritis Treatment and Mechanisms
- Biomarkers in Disease Mechanisms
- Synthesis and biological activity
- MicroRNA in disease regulation
- Biopolymer Synthesis and Applications
Third Hospital of Hebei Medical University
2010-2025
Hebei Medical University
2011-2025
Hospital of Hebei Province
2017-2021
University at Buffalo, State University of New York
2013
Having unique architectural features, cationic polymeric nanocapsules (NCs) with well-defined covalently stabilized biodegradable structures were generated as potentially universal and safe therapeutic nanocarriers. These NCs synthesized from allyl-functionalized polylactide (CPLA) by highly efficient UV-induced thiol–ene interfacial cross-linking in transparent miniemulsions. With tunable nanoscopic sizes, negligible cytotoxicity remarkable degradability, they are able to encapsulate...
Bone regeneration is a complex process that requires the coordination of osteogenesis and osteoclastogenesis. The balance between adipogenesis bone marrow mesenchymal stem cells (BMSCs) plays major role in formation. Recently, intercellular communication surrounding has been gradually recognized, macrophages on surface have proven to regulate metabolism. However, underlying mechanisms not fully elucidated. Recent studies indicated exosomes are vital messengers for cell-cell various...
Sarcopenia, characterized by reduced muscle function as well mass, has been a public health problem with increasing prevalence. It might result from aging, injury, hormone imbalance and other catabolic conditions. Recently, exosomes were considered to regulate regeneration protein synthesis. In order confirm the effect of BMSC-derived (BMSC-Exos) on muscle, dexamethasone-induced atrophy was built both in vitro vivo . present research, BMSC-Exos attenuated decrease myotube diameter induced...
<title>Abstract</title> Coronary heart disease (CHD) is a severe diabetic vascular complication and the main cause of mortality among diabetes patients. Early diagnosis CHD could prevent its development. Both omentin-1 (Oment-1) long noncoding RNA MALAT1 (lncRNA MALAT1) can be detected in peripheral blood exhibit protective or detrimental effects on CHD. However, whether these two factors predictive T2DM patients remains unclear. Therefore, this study aimed to investigate associations...
Abstract Coronary heart disease (CHD) is a severe diabetic vascular complication and the main cause of mortality among diabetes patients. Early diagnosis CHD could prevent its development. Both omentin-1 (Oment-1) long noncoding RNA MALAT1 (lncRNA MALAT1) can be detected in peripheral blood exhibit protective or detrimental effects on CHD. However, whether these two factors predictive T2DM patients remains unclear. Therefore, this study aimed to investigate associations circulating Oment-1...
Diabetes is a worldwide health problem with increasing prevalence. Some reports indicate the interplay between bone and glucose metabolism. The imbalance resorption formation resulted in structural integrity strength of bone. Glucagon-like peptide-1 (GLP-1) its agonists (Liraglutide) have an anabolic action on remodeling by stimulating osteoblast differentiation as well longevity. However, underlying mechanisms remain elusive. We detected presence GLP-1 receptor (GLP-1R) MC3T3-E1 cells via...
Postmenopausal osteoporosis (PMOP), as well its associated increased risk for fragility fracture, is one of the most disabling consequences aging in women. This present study aimed to identify candidate genes that involve pathogenesis PMOP and therapeutic mechanism Liuweidihuang (LWDH) pills on PMOP. We integrated microarray datasets derived from Gene Expression Omnibus (GEO) screen differentially expressed (DEGs) between normal controls patients with after treatment LWDH pills. GO KEGG...
Diabetes is a chronic disease, which may cause various complications. Patients with diabetes are at high risk of bone and joint disorders, such as osteoporosis fractures. In addition, it became widely accepted that has an important impact on metabolism. Metformin commonly used effective first-line treatment for type 2 diabetes. Some glucose-lowering agents have been found to effect The present study explored if different doses metformin mineral density (BMD) metabolism in diabetes.To...
Senile osteoporosis is characterized by increased bone loss and fat accumulation in marrow. Curculigoside (CCG) the major bioactive component of Curculigo orchioides, which has been used as anti-osteoporosis therapy for elder patients since antiquity. We aimed to investigate underlying mechanisms CCG regulated bone-fat balance marrow aging mice. In our study, treatment was identified interfere with stem cell lineage commitment both vivo vitro. vivo, promoted transcriptional co-activator...
This study was aimed to the hypothesis that forkhead box O1 (FOXO1) gene rs17446614 and rs17592236 single nucleotide polymorphisms (SNPs) influenced development of diabetic nephropathy (DN).This included 138 DN patients 149 healthy controls. Controls were matched with in age gender. The method polymerase chain reaction-restriction fragment length (PCR-RFLP) used detect FOXO1 polymorphisms. Haploview software conducted analyze linkage disequilibrium haplotypes Relative risk expressed by odds...
Cadherin-16 (CDH16), a member of the cadherin family adhesion molecules, serves an important role in formation and maintenance thyroid follicular lumen. Decreased expression CDH16 has been reported to be associated with tumor stage papillary cancer (PTC); however, previous analyses have limited biological different subtypes TC is unknown. To investigate occurrence development TC, bioinformatic analysis three (PTC, cell-derived anaplastic TC) was performed using extended data set from Gene...
This study aimed to determine whether RANKL inhibitors in postmenopausal osteoporosis patients with combined type 2 diabetes mellitus (T2DM) could improve their glucose metabolism index. First of all, 84 affected T2DM attending the Department Endocrinology at Third Hospital Hebei Medical University were selected and randomized into two groups 42 each. One group was given Denosumab 60 mg once every six months (denosumab group, D.G.), other ibandronate three (ibandronate I.G.). Blood...