The influence of the glucagon-like peptide-1 receptor (GLP-1R) on bone metabolism is well-established. However, it has been observed that single nucleotide polymorphisms (SNPs) in GLP-1R gene can partially affect its function. Therefore, this study aims to investigate association between SNPs and postmenopausal osteoporosis (PMOP) within Chinese Han population. This employed a cross-sectional case–control design, recruiting total 152 participants, including 76 patients with (OP) (case group)...

Sarcopenia, characterized by reduced muscle function as well mass, has been a public health problem with increasing prevalence. It might result from aging, injury, hormone imbalance and other catabolic conditions. Recently, exosomes were considered to regulate regeneration protein synthesis. In order confirm the effect of BMSC-derived (BMSC-Exos) on muscle, dexamethasone-induced atrophy was built both in vitro vivo . present research, BMSC-Exos attenuated decrease myotube diameter induced...

Abstract This article compares the long-term outcomes of closing-wedge osteotomy (CWO) and opening-wedge (OWO) in treatment unicompartmental medial osteoarthritis with varus deformity. study included 79 patients who underwent high tibial (HTO) between 2002 2008. Pre- postoperative radiography computed tomography were used to evaluate posterior slope, patellar height, tibiofemoral angle, lateral joint space. severity arthritis was assessed Kellgren–Lawrence grading system. American Knee...

BACKGROUND The present study aimed to describe a new safe and economical technique for medial patellofemoral ligament (MPFL) reconstruction with satisfactory clinical outcomes, the results of four-year follow-up. MATERIAL AND METHODS Thirty-two patients recurrent patella dislocation, who underwent MPFL two semi-patellar tunnels hardware-free patellar fixation between 2011 2013, were included in study. Patella stability was tested by an apprehension test preoperatively at Knee function...

Abstract Salvianolic acid B (Sal B), a major bioactive component of Chinese herb, was identified as mediator for bone metabolism recently. The aim this study is to investigate the underlying mechanisms by which Sal regulates osteogenesis and adipogenesis. We used MC3T3‐E1 3T3‐L1 model explore changes cell differentiation induced B. results indicated that at different concentrations had no obvious toxicity effects on proliferation during differentiation. Furthermore, facilitated but inhibited...

Coprinus comatus is an edible and medicinal fungus. In this study, the antioxidant activity of fermentation product C. was investigated through optimization process. The results indicated that had obvious scavenging ability for 2,2'-Azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) free radical. EC50 n-butanol extract from on ABTS·+ 0.65 ± 0.02 mg/mL. On basis, liquid conditions were optimized single factor response surface experiments according to improve capacity product. showed...

Low back pain (LBP) is the primary cause of disability globally. There a close relationship between Modic changes or endplate defects and LBP. Endplates undergo ossification become highly porous during intervertebral disc (IVD) degeneration. In our study, we used mouse model vertebral degeneration by lumbar spine instability (LSI) surgery. Safranin O fast green staining μ CT scan showed that LSI surgery led to porosity, but endplates in sham group were cartilaginous homogenous....

Chronic pain patients lack at-home assessment and management tools. The existing chronic-pain mobile applications are either solely relying on self-report levels or restricted to formal clinical settings. Our app, abbreviated from an NSF-funded project entitled Novel Computational Methods for Continuous Objective Multimodal Pain Assessment Sensing System (COMPASS), is a multi-dimensional app that collects physiological signals predict objective trace daily activities by incorporating...

Mice models of viral pneumonia were induced by pulmonary adaptive strain FM1 influenza A virus in Asian mice.RT-PCR and immunohistochemistry used to dynamically observe the effect Scutellariae Radix on protein gene expression inflammatory cytokine lungs model mice infected at different phases. The partial mechanism repairing immune damage target organs caused was further explored. results showed that reduced proinflammatory cytokines tumor necrosis factor( TNF-α),interleukin IL-1,IL-6 lung...

Background: Pulmonary fibrosis (PF) is a chronic, progressive, and irreversible heterogeneous disease of lung interstitial tissue. To combat progression PF, new drugs are required to be developed. Rhizoma coptidis (COP), one the main alkaloids Coptis chinensis, traditional herbal medicine used treat various inflammatory diseases. Objective: investigate possible effects Coptisine (Cop) on growth, inflammation, as well FMT TNF-β1-induced HFL1 cells uncover mechanism. Material Methods: Human...

The purpose of this study was to evaluate and compare knee kinematics stability following either triangular or anatomical reconstruction the superficial medial collateral ligament (sMCL) posterior oblique (POL). In a cadaveric model (12 knees), two experimental sMCL POL reconstructions were compared in sMCL- POL-deficient knees versus normal knees. first POL, while second involved an POL. All tested through four different states. changes valgus angles, external rotation, internal rotation...

This study aimed to determine whether RANKL inhibitors in postmenopausal osteoporosis patients with combined type 2 diabetes mellitus (T2DM) could improve their glucose metabolism index. First of all, 84 affected T2DM attending the Department Endocrinology at Third Hospital Hebei Medical University were selected and randomized into two groups 42 each. One group was given Denosumab 60 mg once every six months (denosumab group, D.G.), other ibandronate three (ibandronate I.G.). Blood...

Postmenopausal osteoporosis (PMOP) is a prevalent form of primary osteoporosis, affecting over 40% postmenopausal women. Previous studies have suggested potential association between single nucleotide polymorphisms (SNPs) in glucagon-like peptide-1 receptor (GLP-1R) and PMOP Chinese However, available evidence remains inconclusive. Therefore, this study aimed to investigate the possible GLP-1R SNPs Han Thus, we conducted case-control with 152 women aged 45-80 years, including 76 without...

Osteogenesis is tightly correlated with angiogenesis during the process of bone development, regeneration, and remodeling. In addition to providing nutrients oxygen for tissue, blood vessels around tissue also secrete some factors regulate formation. Type H which were regulated by platelet-derived growth factor-BB (PDGF-BB) confirmed couple osteogenesis. Recently, preosteoclasts have been identified as most important source PDGF-BB. Therefore, inhibiting osteoclast maturation, improving...

Low back pain (LBP) is a prevalent disease and can be disabling. Currently, many patients with LBP or without radiculopathy commonly undergo magnetic resonance imaging (MRI) for diagnosis therapeutic assessment, yet the final intervention mainly centered around nonoperative treatment. This study's aim was to identify predictive factors of surgical treatment value MRI in radiculopathy.The study included training cohort that consisted 461 from January 2014 December 2018. Demographic...