A5111063909- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Cancer-related molecular mechanisms research
- Cancer therapeutics and mechanisms
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Polysaccharides and Plant Cell Walls
- Cancer, Lipids, and Metabolism
- Metal complexes synthesis and properties
- Drug Transport and Resistance Mechanisms
- Advancements in Transdermal Drug Delivery
- Liver Disease Diagnosis and Treatment
- Fungal Biology and Applications
- Radiomics and Machine Learning in Medical Imaging
- Traditional Chinese Medicine Analysis
- Urinary and Genital Oncology Studies
- Autopsy Techniques and Outcomes
- Synthesis and biological activity
- Cell death mechanisms and regulation
- Inflammatory Biomarkers in Disease Prognosis
- Urinary Tract Infections Management
- Quinazolinone synthesis and applications
- Frailty in Older Adults
Hangzhou Dianzi University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Fujian Provincial Hospital
2024-2025
Fujian Medical University
2024-2025
Beijing Hospital
2020-2025
Harbin University of Science and Technology
2025
Karolinska Institutet
2024-2025
Zhejiang University
2025
Guangzhou University of Chinese Medicine
2025
Energy Storage Systems (United States)
2025
Abstract Inflammatory bowel disease (IBD) is closely linked to the homeostasis of intestinal environment, and exosomes can be used treat IBD due their high biocompatibility ability effectively absorbed by tract. However, Ginseng-derived nanoparticles (GDNPs) have not been studied in this context mechanism action remains unclear. Here, we investigated GDNPs mediate intercellular communication a complex inflammatory microenvironment order IBD. We found that scavenge reactive oxygen species...
In recent years, transdermal drug delivery systems have gained considerable attention for their ability to enhance patient compliance and provide consistent release. However, the barrier function of skin’s outermost layer remains foremost challenge in these systems. As a result, there is growing interest use ethosomes as cutting-edge nanocarrier delivery. This review presents concept mechanism action well numerous types preparation techniques available. It also discusses significance...
Abstract Apolipoprotein-B (APOB)-containing lipoproteins cause atherosclerosis. Whether the vasculature is initially responding site or if atherogenic dyslipidemia affects other organs simultaneously unknown. Here we show that liver responds to a dyslipidemic insult based on inducible models of familial hypercholesterolemia and APOB tracing. An acute transition lipoprotein levels resulted in uptake by Kupffer cells rapid accumulation triglycerides cholesterol liver. Bulk single-cell RNA...
Natural products have proved to be a promising source for the development of potential anticancer drugs. Emodin, natural compound from Rheum palmatum , is used treat several types cancers, including lung, liver, and pancreatic. However, there are few reports regarding its use in treatment breast cancer. Thus, therapeutic effect mechanism emodin on MCF-7 human cancer cells were investigated this study. Morphological observations cell viability evaluated determine anti-proliferation activity...
Past studies suggested that ginseng extracts and ginseng-derived molecules exerted significant regulatory effects on skin. However, no reports have described the of nanoparticles (GDNPs) skin cell proliferation wound healing. In this study, we investigated whether GDNPs regulate cells promote healing in a mouse model.GDNPs were separated purified via differential centrifugation sucrose/D2O gradient ultracentrifugation. GDNP uptake, cycle progression measured by confocal microscopy, CCK-8...
Predicting the mutation statuses of 2 essential pathogenic genes [epidermal growth factor receptor (
Phloretin (Phl) is a flavonoid compound that contains multiple phenolic hydroxyl groups. It found in many plants, such as apple leaves, lychee pericarp, and begonia, has various biological activities, antioxidant anticancer effects. The strong hydrogen bonding between Phl molecules results poor water solubility low bioavailability, thus the scope of clinical application limited. Therefore, it particularly important to improve for its use further combat or alleviate skin aging oxidative...
The role of ferroptosis-related long non-coding RNAs (lncRNAs) in bladder cancer remains elusive. This study is aimed at examining the prognostic lncRNAs cancer.The transcriptomic matrix and clinical information patients with were obtained from Cancer Genome Atlas (TCGA) database. A lncRNA signature was developed via least absolute shrinkage selection operator (LASSO) analysis using data training cohort, further validated test cohort. AC006160.1, most significant risk signature, examined...
Exosomes are involved in intercellular communication and regulation of the inflammatory microenvironment. In a previous study, we demonstrated that fresh ginseng exosomes (GEs) alleviated bowel disease. However, precise mechanism by which GEs activate immune system subsequently inhibit formation intestinal microenvironment remains unknown. Herein, investigated effects on autophagy, macrophage polarisation, inflammation, epithelial barrier means transcriptome sequencing, network pharmacology,...
Background: Exercise therapy is a core intervention for knee osteoarthritis (KOA). For KOA patients, active and passive stretching exercises can relieve joint pain restore function. Heel kicking exercise (HKE) dynamic method designed by the authors to rapidly reduce function in patients with KOA. This randomized controlled trial was conducted determine efficacy of HKE Method: A total 68 were included this study. Eight excluded, resulting random allocation into control group (N = 29, 1 lost...
Background Patients with small cell lung cancer (SCLC) generally have a poor prognosis, an exceptionally high proliferative rate and strong propensity for early metastasis, indicating the urgent need novel therapies. The development of chimeric antigen receptor (CAR)s targeting solid tumors is limited owing to lack target antigens low efficacy. In this study, we aimed discover new targets SCLC CAR-T therapy develop CAR-T-based combinational treatment against in preclinical models. Methods...