A5029482265- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Metaheuristic Optimization Algorithms Research
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Hepatitis B Virus Studies
- Advanced Multi-Objective Optimization Algorithms
- Vehicle Routing Optimization Methods
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hippo pathway signaling and YAP/TAZ
- Remote Sensing in Agriculture
- Genomics and Phylogenetic Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Remote Sensing and Land Use
- Smart Agriculture and AI
- Respiratory viral infections research
- Genetic diversity and population structure
- Robotic Path Planning Algorithms
- Ubiquitin and proteasome pathways
- Adsorption and biosorption for pollutant removal
- Machine Learning and ELM
- Zeolite Catalysis and Synthesis
- Advanced Neural Network Applications
- Mosquito-borne diseases and control
Southern Medical University
2019-2025
University of North Carolina at Chapel Hill
2025
Northeast Agricultural University
2018-2024
Guizhou Forestry Science Research Institute
2023-2024
Guizhou University
2023
Xinyang Normal University
2020-2021
Shanghai University
2016-2019
Shanghai Institutes for Biological Sciences
2016
Chinese Academy of Sciences
2016
Center for Excellence in Molecular Plant Sciences
2016
Inflammation, epithelial cell regeneration, macrophage polarization, and gut microbial homeostasis are critical for the pathological processes associated with inflammatory bowel disease (IBD). YAP (Yes-associated protein) is a key component of Hippo pathway was recently suggested to promote regeneration IBD recovery. However, it unclear how regulates inflammation, homeostasis. Although has been shown alleviate IBD, here we show that in macrophages aggravates accompanied by production...
ABSTRACT Background and Aims Hepatitis C virus (HCV) vaccines are urgently needed to achieve WHO's goal for the elimination of viral hepatitis by 2030. The lack suitable animal models evaluating vaccine efficacy has greatly hindered development HCV vaccines. By using rat model chronically infected with rodent hepacivirus from Rattus norvegicus (RHV‐rn1), a homologously close as surrogate infection, we assessed protective effectiveness RHV‐rn1 Sad23L‐RHVns. Methods Sad23L‐RHVns was...
Accurate segmentation and detection of rice seedlings is essential for precision agriculture high-yield cultivation. However, current methods suffer from high computational complexity poor robustness to different varieties densities. This article proposes 2 lightweight neural network architectures, LW-Segnet LW-Unet, high-precision seedling segmentation. The networks adopt an encoder-decoder structure with hybrid convolutions spatial pyramid dilated convolutions, achieving accurate while...
COVID-19 vaccines are being developed urgently worldwide. Here, we constructed two adenovirus vectored vaccine candidates of Sad23L-nCoV-S and Ad49L-nCoV-S carrying the full-length gene SARS-CoV-2 spike protein. The immunogenicity was individually evaluated in mice. Specific immune responses were observed by priming a dose-dependent manner, stronger obtained boosting. Furthermore, five rhesus macaques primed with 5 × 109 PFU Sad23L-nCoV-S, followed boosting at 4-week interval. Both mice well...
Introduction Rheumatoid arthritis (RA) primarily affects the joints but can also affect multiple organs and profoundly impacts patients’ ability to carry out daily activities, mental health, life expectancy. Current treatments for RA are limited in terms of duration, efficacy, adverse effects. PD-L1 is a checkpoint protein that plays important roles immune regulation has been implicated initiation progression autoimmune diseases. Method In previous study, we demonstrated intra-articular...
The impact of hepatitis B surface antigen (HBsAg)-negative/hepatitis virus (HBV) DNA-positive occult HBV infection (OBI) on the severity liver fibrosis remains unclear.A total 1772 patients negative for HBsAg but positive antibody to core (HBcAg), stratified by presence or absence OBI, were selected long-term carriage leading elevation ≥2 4 indexes-hyaluronic acid (HA), laminin, type III procollagen peptide (PCIII), and IV collagen (CIV)-at testing in a Chinese hospital. Patients tested...
Occult hepatitis B virus infection (OBI) carries a risk of (HBV) transmission and hepatocellular carcinoma. As previous studies have had limited sample size, the characteristics OBI with genotype C (OBIB OBIC) mutations relating to surface antibody (anti-HBs) elicited by vaccination or host immune response HBV not been fully explored.In this study, occurrence OBIB OBIC strains associated envelope protein (pre-S/S) amino acid substitutions obtained from 99 blood donors stratified according...
The Hippo pathway, which was identified from genetic screens in the fruit fly, Drosophila melanogaster, has a major size-control function animals.All key components of including transcriptional coactivator Yorkie that is most critical substrate and downstream effector kinase cassette, are found silkworm, Bombyx mori.As revealed by microarray quantitative real-time PCR, expression pathway genes particularly enriched several mitotic tissues, ovary, testis, wing disc.Developmental profiles...
Recombinant adenovirus vectors have been widely used in vaccine development. To overcome the preexisting immunity of human type 5 (Ad5) populations, a range chimpanzee or rare generated. However, these novel mediate diverse immune responses hosts. In this study, we explored mechanism differential antibody to SARS-CoV-2 S protein mice immunized by our previously developed two simian 23 (Sad23L) and 49 (Ad49L), Ad5 vectored COVID-19 vaccines. Sad23L-nCoV-S Ad5-nCoV-S vaccines induced low level...
Abstract Background Rhododendron pudingense , firstly discovered in Puding county of Guizhou province 2020, have adapted to living rocky fissure habitat, which has important ornamental and economic values. However, the genetic diversity population structure this species been rarely described, seriously affects collection protection wild germplasm resources. Results In present study, 13 pairs primers for polymorphic microsatellite were used investigate 65 R. accessions from six different...
An improved real-coded genetic algorithm (IRCGA) is proposed to solve constrained optimization problems. First, a sorting grouping selection method given with the advantage of easy realization and not needing calculate fitness value. Secondly, heuristic normal distribution crossover (HNDX) operator proposed. It can guarantee cross-generated offsprings locate closer better one among two parents direction be very close optimal or consistent direction. In this way, HNDX ensure that there great...
SARS-CoV-2 has caused more than 3.8 million deaths worldwide, and several types of COVID-19 vaccines are urgently approved for use, including adenovirus vectored vaccines. However, the thermal instability pre-existing immunity have limited its wide applications. To circumvent these obstacles, we constructed a self-biomineralized vaccine (Sad23L-nCoV-S-CaP) by generating calcium phosphate mineral exterior (CaP) based on Sad23L vector carrying full-length gene spike protein (S) under...
The traveling salesman problem (TSP) is one of the most extensively studied problems in combinatorial optimization area and still presents unsolved challenges due to its NP-hard attribute. Although many real-coded algorithms are available for TSP, they have some performance switch from continuous space discrete perform at low convergence speed. This paper proposes a carnivorous plant algorithm with heuristic decoding method (CPA-HDM) solve (TSP), which exhibits good speed solution accuracy....
Zika virus (ZIKV) has spread in many countries or territories causing severe neurologic complications with potential fatal outcomes. The small primate common marmosets are susceptible to ZIKV, mimicking key features of human infection. Here, a novel simian adenovirus type 23 vector-based vaccine expressing ZIKV pre-membrane-envelope proteins (Sad23L-prM-E) was produced high infectious titer. Due determination immunogenicity mice, single-dose 3×108 PFU Sad23L-prM-E intramuscularly inoculated...