A5100390512- Advanced Sensor and Energy Harvesting Materials
- Advanced Materials and Mechanics
- Tissue Engineering and Regenerative Medicine
- Silicon Nanostructures and Photoluminescence
- Electrospun Nanofibers in Biomedical Applications
- SARS-CoV-2 and COVID-19 Research
- Nanowire Synthesis and Applications
- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- Transplantation: Methods and Outcomes
- Metallurgical Processes and Thermodynamics
- Heart Rate Variability and Autonomic Control
- Microstructure and Mechanical Properties of Steels
- Congenital Diaphragmatic Hernia Studies
- Non-Invasive Vital Sign Monitoring
- COVID-19 and healthcare impacts
- Respiratory viral infections research
- Pancreatitis Pathology and Treatment
- Conducting polymers and applications
- Acute Kidney Injury Research
- Innovative Energy Harvesting Technologies
- Neuroscience and Neural Engineering
- Dielectric materials and actuators
- Cancer survivorship and care
- Hemoglobinopathies and Related Disorders
King's College London
2020-2025
New York University
2024-2025
London Centre for Nanotechnology
2023-2025
Shandong First Medical University
2022-2025
Xi'an University of Science and Technology
2025
Vanderbilt University Medical Center
2023-2025
State Ethnic Affairs Commission
2021-2025
Guangxi University
2025
Affiliated Eye Hospital of Wenzhou Medical College
2025
Wenzhou Medical University
2025
Abstract Muscles featuring high frequency and stroke linear actuation are essential for animals to achieve superior maneuverability, agility, environmental adaptability. Artificial muscles yet match their biological counterparts, due inferior speed, magnitude, mode, or Inspired by the hierarchical structure of natural muscles, artificial created that powerful, responsive, robust, adaptable. The consist knots braided from 3D printed liquid crystal elastomer fibers thin heating threads. unique...
Abstract Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of tooth. This complex structure, periodontium, composed interconnected soft mineralised tissues, posing challenge regenerative approaches. Materials combining silicon lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing stimuli through activation Wnt/β-catenin pathway. Yet,...
Acute kidney injury (AKI) is a serious and fatal complication of acute myocardial infarction (AMI). It has high short- long-term mortality rates poor prognosis but potentially preventable. However, the current incidence, risk factors, outcomes AKI in Chinese population are not well understood would serve first step to identify high-risk patients who could receive preventative care.The medical data 1124 hospitalized diagnosed with AMI from October 2013 September 2015 were reviewed. was...
Abstract On‐skin digitalization, streamlining the concept of “human to device cyberspace” platform, has attracted great attention due its vital function in remote medicine and human–cyber interfaces. Beyond traditional rigid electrodes, soft electrodes with conformal comfortable interfaces are essential for long‐term high‐fidelity signal acquisition. In addition, on‐skin data processing systems will get rid complex cables toward a vision fascinating form, being lightweight, skin‐friendly...
The clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein (Cas) (CRISPR/Cas) systems have recently emerged as powerful molecular biosensing tools based on their collateral cleavage activity due to simplicity, sensitivity, specificity, and broad applicability. However, the direct application of for in situ intracellular detection is still challenging. Here, we debut a CRISPR/Cas-assisted nanoneedle sensor (nanoCRISPR) adenosine triphosphate (ATP), which avoids...
Porous silicon nanoneedles can interface with cells and tissues minimal perturbation for high-throughput intracellular delivery biosensing. Typically, nanoneedle devices are rigid, flat, opaque, which limits their use topical applications in the clinic. We have developed a robust, rapid, precise substrate transfer approach to incorporate within diverse substrates of arbitrary composition, flexibility, curvature, transparency, biodegradability. With this approach, we integrated on medically...
The effect of a simulated reoxidizing environment on the chemical and morphological evolution non-metallic oxide inclusions was studied. Additions 545 ppm 274 soluble oxygen were introduced to an Al killed melt containing approximately 600 Ti Al. It found that inclusion chemistry evolved from Al2O3, Al2TiO5 eventually Ti3O5 for higher addition case Al–Ti complex oxides lower one. Morphologically, it observed irregular gradually replaced by spherical ones during reoxidation process. These...
Abstract Unconventional gas resources from tight sand and shale reservoirs have received great attention in the past decade become focus of petroleum industry as well energy worldwide, because their large reserves technical advances developing unconventional resources. Compared to conventional reservoirs, production ultra-low-permeability is driven by highly non-linear flow equations involves many coexisting processes due presence multi-scale fracture networks, heterogeneous nature a...
Abstract Background 2-phenylethanl (2-PE) and its derivatives are important chemicals, which widely used in food materials fine chemical industries polymers it’s also a potentially valuable alcohol for next-generation biofuel. However, the biosynthesis of 2-PE mainly biotransformed from phenylalanine, price barred production. Therefore, it is necessary to seek more sustainable technologies Results A new strain produces through phenylpyruvate pathway was isolated identified as Enterobacter...
(2020). Characterization of a heparinized decellularized scaffold and its effects on mechanical structural properties. Journal Biomaterials Science, Polymer Edition: Vol. 31, No. 8, pp. 999-1023.
To control the coronavirus disease 2019 (COVID-19) pandemic, there is an urgent need for simple, rapid, and reliable detection methods to identify severe acute respiratory syndrome 2 (SARS-CoV-2) infection, especially in community hospitals or clinical centers. The SARS-CoV-2 nucleocapsid protein (NP) important index diagnosis of COVID-19. Here, we proposed a smartphone-based high-throughput fiber-integrated immunosensing system (HFIS) detecting NP serum samples within 45 min. For testing...
Twelve new isocoumarins, spegazmarins A–L (1–12), including nine novel dimeric derivatives (1–9), three monomeric (10–12), as well eight known ones (13–20), were isolated from the endophytic fungus Spegazzinia sp. MDCW-573. Their structures elucidated by analysis of NMR, X-ray crystallography, and ECD data. Notably, isocoumarins (1–9) possess a unique linkage, where phenyl one monomer is connected to lactone another. The methods for determining configurations both within this class proposed,...
Breast cancer (BC) survivors may experience accelerated aging due to detrimental effects of BC and/or its treatments. Our study aims evaluate Phenotypic Age Acceleration (PAA), a biological age measure, among patients and assess associations with characteristics In this including 1264 (age 54.7±11.7) 429 cancer-free controls 49.9±12.4), we evaluated the differences in PAA (ΔPAA) by treatments at multiple time points using linear mixed models. Overall, had higher than diagnosis (ΔPAA=3.73,...
The relationship between medicinal efficacy and geographical environment in Thesium chinense Turcz., a traditional Chinese herb, remains systematically unexplored. This study integrates metabolomics, machine learning, ecological factor analysis to elucidate the variation patterns regulatory mechanisms of secondary metabolites from Anhui, Henan, Shanxi provinces. Using UHPLC-Q-TOF MS coupled with PCA/PLS-DA multivariate analysis, we identified 43 marker compounds (primarily flavonoids...
Abstract Base editing, a CRISPR‐based genome editing technology, enables precise correction of single‐nucleotide variants, promising resolutive treatment for monogenic genetic disorders like recessive dystrophic epidermolysis bullosa (RDEB). However, the application base editors in cell manufacturing is hindered by inconsistent efficiency and high costs, contributed suboptimal delivery methods. Nanoneedles have emerged as an effective approach, enabling highly efficient, non‐perturbing gene...
Abstract Regulatory T cells (Tregs) play a crucial role in moderating immune responses offering promising therapeutic options for autoimmune diseases and allograft rejection. Genetically engineering Tregs with chimeric antigen receptors (CARs) enhances their targeting specificity efficacy. With non‐viral transfection methods suffering from low efficiency reduced cell viability, viral transduction is currently the only viable approach GMP‐compliant CAR‐Treg production. However, raises...