A5014358931- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- Chemotherapy-induced cardiotoxicity and mitigation
- Animal Disease Management and Epidemiology
- Animal Virus Infections Studies
- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Viral Infections and Vectors
- Pneumonia and Respiratory Infections
- Dental Radiography and Imaging
- Diet and metabolism studies
- Long-Term Effects of COVID-19
- Cancer Risks and Factors
- Biosensors and Analytical Detection
- MicroRNA in disease regulation
- Radiation Dose and Imaging
- Nutritional Studies and Diet
- Herpesvirus Infections and Treatments
- Infection Control and Ventilation
- Data-Driven Disease Surveillance
Jinan University
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2025
Yancheng First People's Hospital
2025
Southwest University
2025
Tri-Service General Hospital
2025
Second Xiangya Hospital of Central South University
2025
Central South University
2025
Jilin Provincial Academy of Forestry Science
2025
Jilin University
2025
Xuzhou Medical College
2025
An outbreak caused by a novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in Wuhan December 2019,1Lu R Zhao X Li J et al.Genomic characterisation and epidemiology of 2019 coronavirus: implications for virus origins receptor binding.Lancet. 2020; (published online Jan 30.)https://doi.org/10.1016/S0140-6736(20)30251-8Summary Full Text PDF Scopus (8212) Google Scholar has since spread within China to other countries. Real-time RT-PCR assays...
A novel coronavirus of zoonotic origin (2019-nCoV) has recently been identified in patients with acute respiratory disease. This virus is genetically similar to SARS and bat SARS-like coronaviruses. The outbreak was initially detected Wuhan, a major city China, but subsequently other provinces China. Travel-associated cases have also reported few countries. Outbreaks health care workers indicate human-to-human transmission. Molecular tests for rapid detection this are urgently needed early...
Coronavirus disease 2019 (COVID-19) is a pandemic with no specific antiviral treatments or vaccines. There an urgent need for exploring the neutralizing antibodies from patients different clinical characteristics.A total of 117 blood samples were collected 70 COVID-19 inpatients and convalescent patients. Antibodies determined modified cytopathogenic neutralization assay (NA) based on live severe acute respiratory syndrome coronavirus 2 enzyme-linked immunosorbent (ELISA). The dynamics...
Abstract Background Coronavirus disease-2019 (COVID-19) has spread widely throughout the world since end of 2019. Nucleic acid testing (NAT) played an important role in patient diagnosis and management COVID-19. In some circumstances, thermal inactivation at 56°C been recommended to inactivate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) before NAT. However, this procedure could theoretically disrupt nucleic integrity single-stranded RNA virus cause false negatives real-time...
supported by the National Major ScienceTthe Chinese Academy of Medical Sciences Innovation Fund for (2020-I2M-Co V19-011 and 2016-I2M-1-014);the Natural Science Foundation China (21525521);the Beijing Advanced Center Structural Biology (ICSB);the Genomics(ICG)
Medical masks are commonly used in health care settings to protect healthcare workers (HCWs) from respiratory and other infections. Airborne pathogens may settle on the surface of layers, resulting contamination. The main aim this study was presence viruses medical masks.Two pilot studies laboratory clinical were carried out determine areas likely contain maximum viral particles. A using a mannequin fluorescent spray showed particles concentrated upper right, middle left sections masks....
Abstract Background COVID-19 is a pandemic with no specific antiviral treatments or vaccines. The urgent needs for exploring the neutralizing antibodies from patients different clinical characteristics are emerging. Methods A total of 117 blood samples were collected 70 inpatients and convalescent patients. presence antibody was determined modified cytopathogenic assay based on live SARS-CoV-2. dynamics levels at analyzed. Results seropositivity rate reached up to 100.0% within 20 days since...
The cloning, expression, and function of the murine (m) homologue human (h) monocyte-derived chemokine (MDC) is reported here. Like hMDC, mMDC able to elicit chemotactic migration in vitro activated lymphocytes monocytes. Among lymphocytes, Th2 cells were induced migrate most efficiently. mRNA protein expression modulated during course an allergic reaction lung. Neutralization with specific Abs a model lung inflammation resulted prevention airway hyperreactivity significant reduction...
With the spread of SARS-CoV-2 worldwide, understanding basic epidemiological parameter values COVID-19 from real-world data in mega-cities is essential for disease prevention and control.To investigate parameters infected cases Beijing, we studied all confirmed close contacts Beijing Jan 1st to Apr 3rd 2020. The virological characteristics were analyzed.A total 602 positive SARS-CoV-2, including 585 patients 17 asymptomatic infections. imported mainly Wuhan initially then abroad. Among...
Recently, microRNA (miRNA)‐mediated RNA interference has been developed as a useful tool in gene function analysis and therapy. A major obstacle miRNA‐mediated RNAi is cellular delivery, which requires an efficient flexible delivery system. The self‐assembly of the MS2 bacteriophage capsids used to develop virus‐like particles (VLPs) for drug delivery. However, VLP‐mediated miRNA not yet reported. We therefore Escherichia coli expression system produce pre‐miR 146a contained VLPs, then...
The first locally acquired case in the Chinese mainland was reported on May 31, 2023, lagging behind other countries. In this study, we aimed to examine early clinical and epidemiological characteristics of earliest cases Mpox Beijing, China. Additionally, investigated sequence transmission patterns virus (MPXV). We analyzed 37 Beijing from 2023 June 21, 2023. age range subjects 24-51 years. Thirty-six (97.3%) were identified men who have sex with (MSM), 19 (51.4%) tested positive for human...
Importance Epidemiological evidence regarding the association between atrial fibrillation (AF) onset age and risk of incident dementia remains unexplored. Objective To examine whether at AF diagnosis is associated with its subtypes. Design, Setting, Participants This prospective, population-based cohort study used data from UK Biobank, a public, open-access database in baseline information collected 2006 to 2010. A total 433 746 participants were included main analysis after excluding or...
Methods: VLPs containing miR-146a, and the control VLPs, were prepared using an Escherichia coli expression system then administered to lupus-prone mice over a 12-day period. We performed enzyme-linked immunosorbent assay evaluate anti-dsDNA antibody, autoantibody nuclear antigen (ANA), total IgG IgM levels in serum. The of miR-146a was analyzed by qRT-PCR. SLE-related cytokines as well some toll-like receptor signaling pathway molecules also measured. Results: Treatment with MS2-miR146a VLP...
BACKGROUND The outbreak of COVID-19 caused by a novel Coronavirus (termed SARS-CoV-2) has spread to over 140 countries around the world. Currently, reverse transcription quantitative qPCR (RT-qPCR) is used as gold standard for diagnostics SARS-CoV-2. However, positive rate RT-qPCR assay pharyngeal swab samples are reported vary from 30∼60%. More accurate and sensitive methods urgently needed support quality assurance or an alternative diagnostic approach. METHODS We established digital PCR...
At the end of 2019 and early 2020, an outbreak pneumonia unknown etiology emerged in city Wuhan China.The cases were found to be caused by a novel beta coronavirus, which was subsequently named SARS-CoV-2 World Health Organization (WHO).The virus has since spread further China other regions world, having infected more than 88 K people, causing close 3000 deaths as March 1, 2020.More 50 million people remain quarantine at this time.Scientists clinicians globally are working swiftly combat...
Background The association of age at coronary heart disease (CHD) onset with incident dementia remains unexplored. This study aimed to examine whether younger CHD is associated a higher risk dementia. Methods and Results Data were obtained from the UK Biobank. Information on diagnosis was collected baseline follow‐ups. Propensity score matching method Cox proportional hazards models used evaluate between different ages A total 432 667 adults (mean±SD age, 56.9±8.1 years) included, whom 11.7%...
We report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection new reassortant different lineages viruses (RVFVs). developed multiorgan dysfunction and gradually recovered continuous renal replacement therapy short regimen methylprednisolone treatment. disordered cytokines chemokines plasma revealed hypercytokinemia, but levels protective were low upon admission fluctuated as disease improved. Whole-genome...
High-altitude cerebral oedema (HACE) is a potentially fatal manifestation of high-altitude sickness and caused partly by inflammation the blood-brain barrier disruption. Tetrahydrocurcumin (THC) has been reported to exert effective antioxidative anti-inflammatory effects; This study sought elucidate underlying mechanism THC in mitigating HACE using mouse model. Our results revealed that prophylactic administration (40 mg/kg) for 3 days significantly alleviated increase brain water content...