A5006386397- Bone Metabolism and Diseases
- Bone health and treatments
- Estrogen and related hormone effects
- Adrenal Hormones and Disorders
- Cytokine Signaling Pathways and Interactions
- Bone health and osteoporosis research
- Vitamin D Research Studies
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Immune Response and Inflammation
- Stress Responses and Cortisol
- Growth Hormone and Insulin-like Growth Factors
- Bone and Dental Protein Studies
- Cell Adhesion Molecules Research
- Retinoids in leukemia and cellular processes
- Osteoarthritis Treatment and Mechanisms
- TGF-β signaling in diseases
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- S100 Proteins and Annexins
- Hormonal and reproductive studies
- Inflammatory mediators and NSAID effects
- Immune Cell Function and Interaction
- Bone and Joint Diseases
- Rheumatoid Arthritis Research and Therapies
The University of Sydney
2016-2025
The Second Affiliated Hospital of Bengbu Medical College
2025
Anzac Research Institute
2015-2024
Nanjing Medical University
2024
Nantong University
2022-2023
Shanxi Medical University
2023
Second Affiliated Hospital of Nantong University
2023
Peking University
2015-2023
University of Electronic Science and Technology of China
2014-2023
Ministry of Education of the People's Republic of China
2023
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, serves as a conduit for migration. Targeting oncogenes involved in angiogenesis needed treat organ-confined locally advanced ESCC. Although phospholipase C epsilon-1 (PLCE1) gene was originally identified susceptibility ESCC, how PLCE1 ESCC unclear. Matrix-assisted laser desorption ionization time-of-flight mass...
Interleukin (IL)-11 is a multifunctional cytokine whose role in osteoclast development has not been fully elucidated. We examined IL-11 production by primary osteoblasts and the effects of rat monoclonal anti-mouse glycoprotein 130 (gp130) antibody on formation, using coculture mouse bone marrow cells. IL-1, TNF alpha, PGE2, parathyroid hormone (PTH) 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25(OH)2D3) similarly induced osteoblasts, but IL-6, IL-4, TGF beta did not. Primary constitutively...
Long-term glucocorticoid treatment is associated with numerous adverse outcomes, including weight gain, insulin resistance, and diabetes; however, the pathogenesis of these side effects remains obscure. Glucocorticoids also suppress osteoblast function, osteocalcin synthesis. Osteocalcin an osteoblast-specific peptide that reported to be involved in normal murine fuel metabolism. We now demonstrate osteoblasts play a pivotal role glucocorticoid-induced dysmetabolism. Osteoblast-targeted...
Lineage commitment of mesenchymal progenitor cells is still poorly understood. Here we demonstrate that Wnt signaling by osteoblasts essential for to differentiate away from a default adipogenic into an osteoblastic lineage. Dominant adipogenesis and reduced osteoblastogenesis were observed in calvarial cell cultures transgenic mice characterized osteoblast-targeted disruption glucocorticoid signaling. This phenotypic shift was associated with reciprocal regulation early osteoblastogenic...
Vitamin D exerts antiproliferative, prodifferentiation, and proapoptotic effects on nonclassic target tissues such as breast. Blood levels of 25-hydroxyvitamin [25(OH)D], the most sensitive indicator vitamin status, are inversely correlated with breast cancer risk; however, a causal relationship between deficiency growth in bone has not been assessed. We examined effect intraskeletal human cell line MDA-MB-231-TxSA murine model malignant lesions. Subsets mice were treated concurrently...
Long-term glucocorticoid (GC) treatment induces central fat accumulation and metabolic dysfunction. We demonstrate that microRNA-27b (miR-27b) plays a role in the pathogenesis of GC-induced accumulation. Overexpression miR-27b had same effects as dexamethasone (DEX) on inhibition brown adipose differentiation energy expenditure primary adipocytes. Conversely, antagonizing function prevented DEX suppression expression tissue–specific genes. GCs transcriptionally regulate through GC...
The function of the epidermal growth factor receptor (EGFR) family member HER4 remains unclear because its activating ligand, heregulin, results in either proliferation or differentiation. This variable response may stem from range signals generated by homodimers versus heterodimeric complexes with other EGFR members. ratio homo- and be influenced both a cell's expression profile ligand even isoform used. To define role mediating antiproliferative differentiation responses, human breast...
Local growth of osteosarcoma involves destruction host bone by proteolytic mechanisms and/or osteoclast activation. Osteoclast formation and activity are regulated osteoblast-derived factors such as the differentiating factor, receptor activator NF-κB ligand (RANKL) inhibitor osteoprotegerin (OPG). We have investigated in vitro effects bisphosphonates on a clonal rat cell line. The aminobisphosphonate pamidronate was added to UMR 106-01 cultures (10−8M 10−4M up 5 days)....
A seasonal component to bone loss has been reported in some postmenopausal women. We hypothesized that elderly women northern New England would be at high risk for during winter because of their age, diet and lack sunlight. Eighteen but healthy (mean age 77 years) started a 2-year observational study remote area northwestern Maine (Greenville: 45.5°N latitude). Fifteen completed the study. Bone mineral density spine (L-BMD) hip (F-BMD) biochemical markers turnover were measured biannually....
Abstract We investigated the sequence of expression osteoblast gene markers during bone formation in vivo by situ hybridization. Cylindrical lesions were induced femora sheep with titanium analytic implants that allow removal serial core samples to study formation. At 2 weeks (2W), granulation tissue made up spindle-shaped cells had partially replaced blood clot. Islands osseous tissue, first noted periphery ingrowing at 3W, became predominant 6W. The surfaces newly forming 3W apposed...
Glucocorticoids are important regulators of bone cell differentiation and mesenchymal lineage commitment. Using a cell-specific approach osteoblast-targeted transgenic disruption intracellular glucocorticoid signaling, we discovered novel molecular pathway by which glucocorticoids, mainly through the mature osteoblast, regulate cellular mechanisms that govern cranial skeleton development. Embryonic neonatal mice revealed distinct phenotype characterized hypoplasia osteopenia skeleton;...
Elevated follicle-stimulating hormone (FSH) activity is proposed to directly cause bone loss independent of estradiol deficiency in aging women. Using transgenic female mice expressing human FSH (TgFSH), we now reveal that TgFSH dose-dependently increased mass, markedly elevating tibial and vertebral trabecular volume. Furthermore, stimulated a striking accrual mass hypogonadal lacking endogenous luteinizing (LH) function, showing FSH-induced occurred independently background LH or levels....
ABSTRACT Changes in the expression of lamin A/C, a fibrilar protein nuclear envelope, are associated with cellular features age‐related bone loss. Reduced A/C inhibits osteoblastogenesis while facilitating adipogenic differentiation mesenchymal stem cells (MSC) vitro and vivo. In this study we investigated regulatory role that plays on essential elements Wnt/β‐catenin pathway, which pivotal MSC differentiation. Initially, assessed effect gene ( LMNA ) overexpression compared it to depleted...
The expression of parathyroid hormone-related protein (PTHrP) was studied in a range cell cultures representative the osteoblast lineage and rat calvarial sections. Primary newborn cells, preosteoblastic line (UMR 201), mouse stromal (ST 2), calvaria-derived osteoblastic (KS 4), osteosarcoma lines 106-01 -06), all expressed PTHrP when examined by reverse transcription polymerase chain reaction (RT-PCR). Using radioimmunoassay we also demonstrated conditioned medium cultured with exception...