A5090098460- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Bone Metabolism and Diseases
- Dental materials and restorations
- 3D Printing in Biomedical Research
- Bone and Dental Protein Studies
- Titanium Alloys Microstructure and Properties
- Osteoarthritis Treatment and Mechanisms
- Graphene and Nanomaterials Applications
- Silk-based biomaterials and applications
- Nanocluster Synthesis and Applications
- Cellular Mechanics and Interactions
- Additive Manufacturing and 3D Printing Technologies
- Carbon and Quantum Dots Applications
- Mesenchymal stem cell research
- Calcium Carbonate Crystallization and Inhibition
- Periodontal Regeneration and Treatments
- Metal and Thin Film Mechanics
- Facial Trauma and Fracture Management
- biodegradable polymer synthesis and properties
- S100 Proteins and Annexins
- Electrospun Nanofibers in Biomedical Applications
- Polymer Surface Interaction Studies
- Advanced biosensing and bioanalysis techniques
The University of Sydney
2016-2025
Australian Research Council
2018-2023
Engineering (Italy)
2021
Bioengineering Center
2021
Faculty (United Kingdom)
2021
Royal North Shore Hospital
2020
NanoScale Corporation (United States)
2019
Harvard University
2017-2019
Institute for Advanced Study
2017-2019
Shanghai Ninth People's Hospital
2018
Abstract Poor cell adhesion to orthopaedic and dental implants may result in implant failure. Cellular biomaterial surfaces primarily is mediated by integrins, which act as signal transduction proteins. Because integrin function depends on divalent cations, we investigated the effect of magnesium ions modified bioceramic substrata (Al 2 O 3 ‐Mg 2+ ) human bone‐derived (HBDC) adhesion, expression, activation intracellular signalling molecules. Immunohistochemistry, flow cytometry, blocking,...
Abstract A challenge in regenerating large bone defects under load is to create scaffolds with and interconnected pores while providing a compressive strength comparable cortical (100–150 MPa). Here we design novel hexagonal architecture for glass-ceramic scaffold fabricate an anisotropic, highly porous three dimensional of 110 MPa. Scaffolds demonstrated high fatigue resistance (1,000,000 cycles at 1–10 MPa cyclic load), failure reliability flexural (30 MPa) compared those conventional...
Mesenchymal stem cells (MSCs) have been widely used for tissue repair and regeneration. However, the inherent drawbacks, including limited cell survival after transplantation, hindered direct MSC transplantation The aim of this study was to investigate if exosomes isolated from MSCs can promote proliferation differentiation human primary osteoblastic (HOBs) be potentially bone We showed that adipose tissue-derived (ASC)-derived (ASC-EXO) were able osteogenic in HOBs; trophic effects ASC-EXO...
The management and reconstruction of damaged or diseased skeletal tissues have remained a significant global healthcare challenge. limited efficacy conventional treatment strategies for large bone, cartilage osteochondral defects has inspired the development scaffold-based tissue engineering solutions, with aim achieving complete biological functional restoration affected in presence supporting matrix. Nevertheless, regulatory hurdles rendered clinical translation novel scaffold designs to...
The successful regeneration of functional bone tissue in critical-size defects remains a significant clinical challenge. To address this challenge, synthetic scaffolds are widely developed, but remarkably few translated to the clinic due poor performance vivo. Here, it is demonstrated how architectural design 3D printed can improve vivo outcomes. Ceramic with different pore sizes and permeabilities, similar porosity interconnectivity, implanted rabbit calvaria for 12 weeks, then explants...