A5025485180- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- biodegradable polymer synthesis and properties
- Magnesium Alloys: Properties and Applications
- Nanowire Synthesis and Applications
- Silicon Nanostructures and Photoluminescence
- Laser-Ablation Synthesis of Nanoparticles
- Wound Healing and Treatments
- Titanium Alloys Microstructure and Properties
- Graphene and Nanomaterials Applications
- Nanoparticles: synthesis and applications
- Advanced Sensor and Energy Harvesting Materials
- Silk-based biomaterials and applications
- Orthopaedic implants and arthroplasty
- Anodic Oxide Films and Nanostructures
- Aluminum Alloys Composites Properties
- Tissue Engineering and Regenerative Medicine
- Additive Manufacturing and 3D Printing Technologies
- Nanocomposite Films for Food Packaging
- Hydrogen Storage and Materials
- Polysaccharides and Plant Cell Walls
- Advanced biosensing and bioanalysis techniques
- Corrosion Behavior and Inhibition
- Polymer composites and self-healing
- Advancements in Transdermal Drug Delivery
Indian Institute of Technology Delhi
2019-2025
All India Institute of Medical Sciences
2023-2025
King's College London
2023-2024
Indian Institute of Technology Bombay
2018-2020
Indian Institute of Technology Roorkee
2013-2017
Background: Nanoparticles (NPs) have gained significance in medical fields due to their high surface-area-to-volume ratio. In this study, we synthesized NPs from a medicinally important plant – Plumbago zeylanica . Materials and methods: Aqueous root extract of P. (PZRE) was analyzed for the presence flavonoids, sugars, organic acids using high-performance thin-layer chromatography (HPTLC), gas chromatography-time flight-mass spectrometry (GC-TOF-MS), biochemical methods. The silver (AgNPs),...
Abstract Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of tooth. This complex structure, periodontium, composed interconnected soft mineralised tissues, posing challenge regenerative approaches. Materials combining silicon lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing stimuli through activation Wnt/β-catenin pathway. Yet,...
Porous silicon nanoneedles can interface with cells and tissues minimal perturbation for high-throughput intracellular delivery biosensing. Typically, nanoneedle devices are rigid, flat, opaque, which limits their use topical applications in the clinic. We have developed a robust, rapid, precise substrate transfer approach to incorporate within diverse substrates of arbitrary composition, flexibility, curvature, transparency, biodegradability. With this approach, we integrated on medically...
Additive manufacturing (AM) using laser powder bed fusion (LPBF) enables the fabrication of intricate biomimetic structures, such as triply periodic minimal surfaces (TPMS), which hold significant potential for biomedical implants. However, fatigue performance these structures is often compromised by surface roughness and internal defects. In this work, Triply (TPMS) based lattices were fabricated LPBF process. Quasi‐static compression tests computational fluid dynamics (CFD) simulations...
Ferulic acid is a ubiquitous phytochemical that holds enormous therapeutic potential but has not gained much consideration in biomedical sector due to its less bioavailability, poor aqueous solubility and physiochemical instability. In present investigation, the shortcomings associated with agro-waste derived ferulic were addressed by encapsulating it electrospun nanofibrous matrix of poly (d,l-lactide-co-glycolide)/polyethylene oxide. Fluorescent microscopic analysis revealed predominantly...
Ferulic acid (FA) is a polyphenolic phytonutrient which possesses strong antiproliferative effect; however, it has limited therapeutic applications due to its physiochemical instability and low bioavailability at the tumor site. In present study, these shortcomings associated with FA were overcome by fabricating FA-encapsulated poly(D,L-lactide-co-glycolide)/polyethylene oxide (PLGA/PEO) blend nanofibers using electrospinning technique. FESEM fluorescence microscopic analysis imitates smooth...
In this study, nanofibers against pro dimorphic fungal sessile growth were developed. Quercetin was successfully encapsulated within poly(d,l-lactide- co-glycolide)–poly(ε-caprolactone) using an electrospinning technique. Field emission scanning electron microscopy, fluorescent and Fourier-transformed infrared spectrometer used to confirm the formation as well encapsulation of quercetin nanofibers. These fabricated further evaluated determine effectiveness antibiofilm activity Candida...
Abstract The aim of this work was to develop a complex-shaped gelatin–gellan composite scaffold with multiscale porosity using combination cryogenic 3D printing and lyophilization for bone tissue engineering. Cryogenic used fabricate low-concentration macroporous structures pore size 919 ± 89 µm. This followed by introduce micropores 20–250 µm nanometre-level surface functionalities, thus achieving hierarchical porous structure. These scaffolds (GMu) were compared two other types having only...
Quercetin is a potent natural antioxidant but has limited therapeutic applications due to its short half-life in body fluids. In order improve the efficacy of quercetin and overcome shortcomings, quercetin-encapsulated electrospun poly(lactic-co-glycolic acid)–poly(ε-caprolactone) nanofibrous controlled release system was developed using electrospinning technique. Fourier transform infrared spectroscopy, thermogravimetric, X-ray diffraction analysis suggested incorporation, thermal...
Regeneration of injured neuronal areas is a big challenge owing to the complex structure and function nervous system along with limited regeneration capacity neural cells. Recent reports show that patterned functionalized scaffolds could control cell directional growth. In this study, aligned nanofibers (ANFs) were fabricated using versatile cost-effective approach, electrospinning, further processed make hybrid scaffold (HANF). The had circular rings ANFs reinforced in biocompatible...
PLA and its blends are the most extensively used materials for various biomedical applications such as scaffolds, implants, other medical devices. The method tubular scaffold fabrication is by using extrusion process. However, scaffolds show limitations low mechanical strength compared to metallic inferior bioactivities, limiting their clinical application. Thus, in order improve properties of they were biaxially expanded, wherein bioactivity can be improved surface modifications UV...
The ability of bone to regenerate itself through mechanobiological responses is its dynamic property. Mechanical cues from a neighboring environment produce the structural strain promote blood flow and marrow mobility that in turn aids regeneration process. Occurrences these phenomena are crucial for success metallic scaffolds implanted host tissue. Thus, permeability fluid flow-induced wall shear stress (WSS) two parameters directly influence cell bioactivities inside scaffold effective...
Abstract Engineering the spatial organisation of organotypic cultures is pivotal for refining tissue models that are useful gaining deeper insights into complex, non‐cell autonomous processes. These advanced key to improving understanding fundamental biological mechanisms and therapeutic strategies. Controlling gene regulation through spatially‐resolved delivery nucleic acids provides an attractive approach produce such models. An emerging strategy transfection uses photosensitizing...