A5075580632- Particle physics theoretical and experimental studies
- Mosquito-borne diseases and control
- Marine Biology and Environmental Chemistry
- Cancer, Lipids, and Metabolism
- Bioactive Compounds and Antitumor Agents
- Insect Resistance and Genetics
- NF-κB Signaling Pathways
- Environmental Toxicology and Ecotoxicology
- Insect symbiosis and bacterial influences
- Neurobiology and Insect Physiology Research
- Particle Detector Development and Performance
- Particle Accelerators and Free-Electron Lasers
- Prostate Cancer Treatment and Research
- Genomics, phytochemicals, and oxidative stress
- Invertebrate Immune Response Mechanisms
- Adrenal Hormones and Disorders
- Radiation Therapy and Dosimetry
- Electrospun Nanofibers in Biomedical Applications
- Natural Antidiabetic Agents Studies
- Histone Deacetylase Inhibitors Research
- Plant biochemistry and biosynthesis
- Bioactive Compounds in Plants
- Wound Healing and Treatments
- Bone Metabolism and Diseases
- Insect and Pesticide Research
Purdue University West Lafayette
2017-2022
Indian Institute of Technology Roorkee
2013-2019
University of Pittsburgh
2019
Fermi National Accelerator Laboratory
2019
Instituto Politécnico Nacional
2019
European Organization for Nuclear Research
2018-2019
Kurchatov Institute
2019
Institute of Space Science - INFLPR Subsidiary
2019
National Research Tomsk State University
2019
Bhabha Atomic Research Centre
2019
Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of developing tools to fight them has been slowed by lack a high-quality genome assembly. Here we combine diverse technologies produce markedly improved, fully re-annotated AaegL5 assembly, demonstrate how it accelerates mosquito science. We anchored physical cytogenetic maps, doubled number...
We present the first application of three-dimensional convolutional Generative Adversarial Network to High Energy Physics simulation. generate images particles depositing energy in high granularity calorimeters. This is time such an approach taken HEP where most data nature but it customary convert into two-dimensional slices. The work proves success using three dimensional GAN. showers are well reproduced all dimensions and show a good agreement with standard techniques (Geant4 detailed...
Chemotherapy and anti-hormonal therapies are the most common treatments for non-organ-confined prostate cancer (PCa). However, effectiveness of these is limited, thus necessitating development alternative approaches. The present study focused on analyzing role pterostilbene (PTER)-isothiocyanate (ITC) conjugate – a novel class hybrid compound synthesized by appending an ITC moiety PTER backbone in regulating functions androgen receptor (AR), thereby causing apoptosis PCa cells. molecule...
Trans-3,5-dimethoxy-4′-hydroxystilbene (PTER), a natural dimethylated analog of resveratrol, preferentially induces certain cancer cells to undergo apoptosis and could thus have role in chemoprevention. Peroxisome proliferator-activated receptor γ (PPARγ), member the nuclear superfamily, is ligand-dependent transcription factor whose activation results growth arrest and/or variety cells. Here we investigated potential PTER-isothiocyanate (ITC) conjugate, novel class hybrid compound...
Female Aedes aegypti mosquitoes infect hundreds of millions people each year with dangerous viral pathogens including dengue, yellow fever, Zika, and chikungunya. Progress in understanding the biology this insect, developing tools to fight it, has been slowed by lack a high-quality genome assembly. Here we combine diverse technologies produce AaegL5, dramatically improved annotated assembly, demonstrate how it accelerates mosquito science control. We anchored physical cytogenetic maps,...
In the fall 2016, GeantV went through a thorough community evaluation of project status and its strategy for sharing R&D results with LHC experiments HEP simulation in general. Following this discussion, has engaged onto an ambitious 2-year road-path aiming to deliver beta version that most final design several performance features product, partially integrated some experiment's frameworks. The initial prototype been updated vector-aware concurrent framework, which is able high-density...
New classes of chemistries are needed to control insecticide resistant populations mosquitoes and prevent transmission vector-borne diseases (VBDs). Organismal screens chemical collections have played an important role in the search for new vector insecticides identification active ingredients (AIs) that cause rapid mortality mosquitoes. Advances image-based screening offer opportunity identify operate via novel biochemical modes investigate range phenotypes exhibited by following exposure...
SIMD acceleration can potentially boost by factors the application throughput. Achieving efficient vectorization for scalar code with complex data flow and branching logic, goes however way beyond breaking some loop dependencies relying on compiler. Since refactoring effort scales number of lines code, it is important to understand what kind performance gains be expected in such cases. We started investigate a couple years ago top bottom approach particle transport simulation. Percolating...
The development of the GeantV Electromagnetic (EM) physics package has evolved following two necessary paths towards code modernization. A first phase required revision main electromagnetic models and their implementation. objectives were to improve accuracy, extend them new high-energy frontier posed by Future Circular Collider (FCC) programme allow a better adaptation multi-particle flow. Most EM in have been reviewed from theoretical perspective rewritten with vector-friendly...
The androgen receptor (AR) signalling axis plays a vital role in the development, function and homeostasis of prostate. classical action AR is to regulate gene transcriptional processes successively via nuclear translocation, binding response elements on target genes recruitment of, or crosstalk with, transcription factors. Dysregulation androgen/AR perturbs normal reproductive development accounts for wide range pathological conditions such as androgen-insensitive syndrome, prostate cancer...