A5065946860- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Lanthanide and Transition Metal Complexes
- Nonlinear Optical Materials Studies
- Mesoporous Materials and Catalysis
- Silicon Nanostructures and Photoluminescence
- Carbohydrate Chemistry and Synthesis
- Photoacoustic and Ultrasonic Imaging
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Metal complexes synthesis and properties
- Nanowire Synthesis and Applications
- Glycosylation and Glycoproteins Research
- Magnetism in coordination complexes
- Traditional and Medicinal Uses of Annonaceae
- Lysosomal Storage Disorders Research
- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Self-Assembly in Materials
- Ubiquitin and proteasome pathways
- Supramolecular Chemistry and Complexes
Institut des Biomolécules Max Mousseron
2016-2025
École Nationale Supérieure de Chimie de Montpellier
2015-2024
Université de Montpellier
2015-2024
Centre National de la Recherche Scientifique
2015-2024
Pharmac
2015-2020
Centre Occitanie-Montpellier
2015-2020
Bipar
2015-2020
3M (United States)
2015
Institut Charles Gerhardt Montpellier
2013-2015
Institut de Recherche en Cancérologie de Montpellier
2008-2013
This study investigates the effects of SR141716, a selective CB<sub>1</sub> receptor antagonist that reduces food intake and body weight rodents, on Acrp30 mRNA expression in adipose tissue. Acrp30, plasma protein exclusively expressed secreted by tissue, has been shown to induce free fatty acid oxidation, hyperglycemia hyperinsulinemia decrease, reduction. We report that<i>N</i>-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1<i>H</i>-pyrazole-3-carboximide...
This study investigated the effects of rimonabant (SR141716), an antagonist cannabinoid receptor type 1 (CB1), on obesity-associated hepatic steatosis and related features metabolic syndrome: inflammation (elevated plasma levels tumor necrosis factor alpha [TNFalpha]), dyslipidemia, reduced adiponectin. We report that oral treatment obese (fa/fa) rats with (30 mg/kg) daily for 8 weeks abolished steatosis. hepatomegaly, elevation enzyme markers damage (alanine aminotransferase, gamma...
Zap 'em! Multifunctionalized mesoporous silica nanoparticles induce significant reduction of tumor size upon two-photon excitation in the near-infrared region while being nontoxic under daylight illumination. These were further tested for vivo photodynamic therapy (TPE-PDT). A 70 % regression after a single treatment was observed athymic mice bearing xenografts. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not...
Functionalisation of MSN with mannose for PDT applications dramatically improved the efficiency on breast cancer cells.
Porous silicon nanoparticles (pSiNPs) act as a sensitizer for the 2-photon excitation of pendant porphyrin using NIR laser light, imaging and photodynamic therapy. Mannose-functionalized pSiNPs can be vectorized to MCF-7 human breast cancer cells through mannose receptor-mediated endocytosis mechanism provide 3-fold enhancement PDT effect.
Mesoporous silica nanoparticles (MSN) are functionalized in the walls with an original fluorophore a high two-photon absorption cross-section. The pores of MSN filled anticancer drug blocked pseudo-rotaxane constituted by azobenzene stalk and β-cyclodextrin moiety. After incubation nanosystem MCF-7 breast cancer cells, irradiation at low power is used to image cells. At power, cell killing observed due two-photon-triggered opening through FRET release from MSN.
A therapy of cancer cells: Two-photon-triggered camptothecin delivery (see picture) with nanoimpellers was studied in MCF-7 breast cells. fluorophore a high two-photon absorption cross-section first incorporated the nanoimpellers. Fluorescence resonance energy transfer (FRET) from to azobenzene moiety demonstrated.
In addition to the already described ligand L4a, two pyclen-based lanthanide chelators, L4b and L4c, bearing specific picolinate two-photon antennas (tailor-made for each targeted metal) one acetate arm arranged in a dissymmetrical manner, have been synthesized, form complete family of luminescent bioprobes: [EuL4a], [SmL4a], [YbL4b], [TbL4c], [DyL4c]. Additionally, symmetrically regioisomer L4a′ was also synthesized as well its [EuL4a′] complex highlight astonishing positive impact...
Adipocyte cell proliferation is an important process in body fat mass development obesity. Adiponectin or Acrp30 adipocytokine exclusively expressed and secreted by adipose tissue that regulates lipid glucose metabolism plays a key role weight regulation homeostasis. mRNA expression plasma level of adiponectin are decreased obesity type 2 diabetes. In obese rodents, the selective CB(1) receptor antagonist rimonabant reduces food intake improves parameters. We have reported previously...
Three dimensional sub-micron resolution has made two-photon nanomedicine a very promising medical tool for cancer treatment since current techniques cause significant side effects lack of spatial selectivity. Two-photon-excited (TPE) photodynamic therapy (PDT) been achieved via mesoporous nanoscaffolds, but the efficiency could still be improved. Herein, we demonstrate enhancement gold-mesoporous organosilica nanocomposites TPE-PDT in cells when compared to particles. We performed first...
In this work, we describe the synthesis of new Mixed Periodic Mesoporous Organosilica Nanoparticles (MPMO NPs), combining co-condensation a tetra-trialkoxysilylated two-photon photosensitizer with bis-(triethoxysilyl)phenylene or ethylene. Novel gold core-MPMO shell systems are also described. The MPMO NPs analyzed and characterized by multiple techniques, very efficient for anti-cancer drug delivery combined therapy in MCF-7 breast cancer cells, leading down to 76% cell death. thus...
Abstract Periodic mesoporous organosilica nanoparticles emerge as promising vectors for nanomedicine applications. Their properties are very different from those of well‐known silica there is no source their synthesis. So far, they have only been synthesized small bis‐silylated organic precursors. However, studies employing large stimuli‐responsive precursors reported on such hybrid systems yet. Here, the synthesis porphyrin‐based a octasilylated metalated porphyrin precursor described...
Multifunctionalized porous silicon nanoparticles (pSiNPs), containing the novel Ru(ii) complex-photosensitizer, polyethylene glycol moiety, and mannose molecules as cancer targeting ligands, are constructed showcased for application in near infrared (NIR) light-responsive photodynamic therapy (PDT) imaging of cancer. Exposure to NIR light leads two-photon excitation Ru(ii)-complex which allows efficient simultaneous cancer-imaging targeted PDT with functionalized biodegradable pSiNP nanocarriers.
Herein, we report for the first time a biocompatible cross-linked trianglamine (Δ) network efficient iodine removal from vapor phase, water, and seawater. In could capture 6 g g-1 of iodine, ranking among most performant materials capture. liquid this is also capable capturing at high rates aqueous media (water seawater). This displayed fast adsorption kinetics, they are fully recyclable. study reveals affinity intrinsic cavity trianglamine. The synthesized extremely interesting since...
Bei Zweiphotonenanregung im Nahinfrarot schrumpfen hoch funktionalisierte mesoporöse Siliciumdioxid-Nanopartikel Tumoren beträchtlich, bei Tageslichtbestrahlung sind sie hingegen ungiftig. Die Nanopartikel führten In-vivo-Versuchen zur photodynamischen Therapie (PDT) mit an athymischen Mäusen Fremdtumoren zu einem Rückgang der Tumorgröße um 70 % nach einer einzigen Behandlung.
Non-toxic porous silicon nanoparticles carry porphyrin covalently attached to their surface inside breast cancer cells for a more efficient photodynamic effect.
The aspartic protease cathepsin D, a poor prognostic indicator of breast cancer, is abundantly secreted as procathepsin D by human cancer cells and self-activates at low pH in vitro, giving rise to catalytically active D. Due lower extracellular tumor microenvironments compared normal tissues, may cleave pathophysiological substrates contributing progression. Here, we show yeast 2-hybrid degradomics analyses that cystatin C, the most potent natural inhibitor cysteine cathepsins, both binds...
Cancer has become a global public health problem and the search for new control measures is urgent. Investigation of plant products such as essential oils from Monodora myristica, Xylopia aethiopica parviflora might lead to anticancer therapy. In this study, we have investigated antineoplastic activity fruits these plants growing in Chad Cameroon. The obtained by hydrodistillation collected Cameroon were analyzed GC-FID GC-MS their antiproliferative against breast cancer cell line (MCF7)....
Abstract The development of personalized and non‐invasive cancer therapies based on new targets combined with nanodevices is a major challenge in nanomedicine. In this work, the over‐expression membrane lectin, cation‐independent mannose 6‐phosphate receptor (M6PR), was specifically demonstrated prostate cell lines tissues. To efficiently target lectin mannose‐6‐phosphate analogue synthesized six steps grafted onto surface functionalized mesoporous silica nanoparticles (MSNs). These MSNs...
A two-photon photosensitizer with four triethoxysilyl groups is synthesized through the click reaction. This allows design of bridged silsesquioxane (BS) nanoparticles a sol-gel process; moreover, gold core BS shells or decorated nanospheres are synthesized. An enhancement properties noted and efficient for imaging photodynamic therapy cancer cells.
Biodegradable bridged silsesquioxane nanoparticles for two-photon imaging and therapy of cancer cells are described.