A5061797775- Nanoplatforms for cancer theranostics
- Protein Structure and Dynamics
- Influenza Virus Research Studies
- Computational Drug Discovery Methods
- RNA and protein synthesis mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- Adsorption and Cooling Systems
- Tea Polyphenols and Effects
- Luminescence and Fluorescent Materials
- Testicular diseases and treatments
- Phytochemicals and Antioxidant Activities
- SARS-CoV-2 and COVID-19 Research
- Phase Change Materials Research
- Bacteriophages and microbial interactions
- Advanced Sensor and Energy Harvesting Materials
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Catalytic C–H Functionalization Methods
- Synthesis and Biological Evaluation
- Conducting polymers and applications
- COVID-19 Clinical Research Studies
- Chemical Synthesis and Analysis
- Opportunistic and Delay-Tolerant Networks
- Glycosylation and Glycoproteins Research
Xi'an Jiaotong University
2016-2025
University of Science and Technology Beijing
2013-2025
Central South University
2025
Drexel University
2025
The First People's Hospital of Changde
2025
Daqing Oilfield General Hospital
2011-2024
Sinopec (China)
2024
Sun Yat-sen University
2013-2024
Chinese Academy of Sciences
2001-2024
Xinjiang Technical Institute of Physics & Chemistry
2024
Abstract In face of the everlasting battle toward COVID-19 and rapid evolution SARS-CoV-2, no specific effective drugs for treating this disease have been reported until today. Angiotensin-converting enzyme 2 (ACE2), a receptor mediates virus infection by binding to spike protein. Although ACE2 is expressed in lung, kidney, intestine, its expressing levels are rather low, especially lung. Considering great infectivity COVID-19, we speculate that SARS-CoV-2 may depend on other routes...
The multifunctional cytokine transforming growth factor (TGF) β1 is secreted in a latent complex with its processed propeptide (latency-associated peptide [LAP]). TGFβ1 must be functionally released from this before it can engage TGFβ receptors. One mechanism of activation involves interaction the integrins αvβ6 and αvβ8 an RGD sequence LAP; other putative activators include thrombospondin-1, oxidants, various proteases. To assess contribution RGD-binding to vivo, we created mutation Tgfb1...
Pd-catalyzed decarboxylative cross-couplings of 2-(2-azaaryl)acetates with aryl halides and triflates have been discovered. This reaction is potentially useful for the synthesis some functionalized pyridines, quinolines, pyrazines, benzoxazoles, benzothiazoles. Theoretical analysis shows that nitrogen atom at 2-position heteroaromatics directly coordinates to Pd(II) in decarboxylation transition state.
Chiral nanoporous metal–organic frameworks are constructed by using dicarboxyl-functionalized chiral Ni(salen) and Co(salen) ligands. The Co(salen)-based framework is shown to be an efficient recyclable heterogeneous catalyst for hydrolytic kinetic resolution (HKR) of racemic epoxides with up 99.5% ee. MOF structure brings units into a highly dense arrangement close proximity that enhances bimetallic cooperative interactions, leading improved catalytic activity enantioselectivity in HKR...
Abstract Smart skin is expected to be stretchable and tactile for bionic robots as the medium with ambient environment. Here, a triboelectric–photonic smart (STPS) reported that enables multidimensional gesture sensing robotic hand. With grating‐structured metal film bioinspired stripe, STPS exhibits tunable aggregation‐induced emission in lateral tensile range of 0–160%. Moreover, can used triboelectric nanogenerator vertical pressure maximum sensitivity 34 mV Pa −1 . The characteristics...
The physical filtration mechanism of a traditional face mask has low removal efficiency ultrafine particulates in the size range 10–1000 nm, which are badly harmful to human health. Herein, novel self-powered electrostatic adsorption (SEA-FM) based on poly(vinylidene fluoride) electrospun nanofiber film (PVDF-ESNF) and triboelectric nanogenerator (TENG) driven by respiration (R-TENG) is developed. electrostatically adsorbed PVDF-ESNF, R-TENG can continually provide charges this process...
Abstract Nanozymes are considered as the promising antimicrobial agents due to enzyme‐like activity for chemo‐dynamic therapy (CDT). However, it remains a challenge develop novel nanozyme systems achieving stimuli‐responsive, and efficient catalysis with multimodal synergistic enhancement. In this work, near‐infrared (NIR) plasmonic‐enhanced photothermal performance effective applications proposed. A Ti 3 C 2 MXene/Fe‐MOFs composite (MXM) NIR CDT combined properties is successfully developed...
In experimental models, lung fibrosis is dependent on transforming growth factor (TGF)-beta signaling. TGF-beta secreted in a latent complex with its propeptide, and activators release from this complex. Because the integrin alpha(v)beta6 major activator lung, inhibition of alpha(v)beta6-mediated activation logical strategy to treat fibrosis.To determine, by genetic pharmacologic approaches, whether murine radiation-induced alpha(v)beta6.Wild-type mice, alpha(v)beta6-deficient (Itgb6-/-)...
Two chiral carboxylic acid functionalized micro- and mesoporous metal-organic frameworks (MOFs) are constructed by the stepwise assembly of triple-stranded heptametallic helicates with six groups. The MOF permanent porosity functions as a host for encapsulation an enantiopure organic amine catalyst combining acids amines in situ through acid-base interactions. organocatalyst-loaded framework is shown to be efficient recyclable heterogeneous asymmetric direct aldol reactions significantly...
A highly efficient dual-modal imaging platform by using bright AIE dots was constructed to achieve precise cancer diagnostics.
Metal–organic frameworks (MOFs) are significant useful molecular materials as a result of their high surface area and flexible catalytic activities by tuning the metal centers ligands. MOFs have attracted great attention efficient nanozymes recently; however, it is still difficult to understand polymetallic for enzymatic catalysis because complicated structure interactions. Herein, bimetallic NiFe2 MOF octahedra were well prepared exhibited enhanced peroxidase-like activities. The...
Metal–organic frameworks (MOFs) are widely used to mimic enzymes for catalyzing chemical reactions; however, low enzyme activity limit their large-scale application. In this work, gold nanorods/metal–organic (Au NRs/Fe-MOF) hybrids were successfully synthesized photo-enhanced peroxidase-like catalysis and surface-enhanced Raman spectroscopy (SERS). The enzyme-like of Au NRs/Fe-MOF was significantly enhanced under localized surface plasmon resonance (LSPR), because the hot electrons produced...
Aggregation-induced emission (AIE) nanoparticles have been widely applied in photodynamic therapy (PDT) over the past few years. However, amorphous nanoaggregates usually occur their preparation, resulting loose packing with disordered molecular structures. This still allows free intramolecular motions, thus leading to limited brightness and PDT efficiency. Herein, we report deep-red AIE nanocrystals (NCs) of DTPA-BS-F by following facile method nanoprecipitation. It is observed that NCs...
Organelle-specific imaging and dynamic tracking in ultrahigh resolution is essential for understanding their functions biological research, but this remains a challenge. Therefore, facile strategy by utilizing anion-π+ interactions proposed here to construct an aggregation-induced emission luminogen (AIEgen) of DTPAP-P, not only restricting the intramolecular motions also blocking strong π-π interactions. DTPAP-P exhibits high photoluminescence quantum yield (PLQY) 35.04% solids, favorable...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSequence Selective Binding of Peptides by Artificial Receptors in Aqueous SolutionRonald Breslow, Zhiwei Yang, Rachel Ching, Gunter Trojandt, and Fabrice OdobelView Author Information Department Chemistry, Columbia University New York, York 10027 Cite this: J. Am. Chem. Soc. 1998, 120, 14, 3536–3537Publication Date (Web):March 28, 1998Publication History Received24 November 1997Published online28 March 1998Published inissue 1 April...
Several phthalocyanines carrying hydrophobic components have been synthesized and shown to bind a group of cyclodextrin dimers with carbon−carbon double bond in the linker. The complexes are soluble water. On irradiation presence oxygen, singlet oxygen produced cleaves olefinic linkers complexes, resulting precipitation sensitizers. This process concentrates sensitizers light beam, that has useful potential photodynamic therapy.
ABSTRACT The aim of this study was to investigate the antimicrobial activity cinnamaldehyde, thymol and carvacrol alone or their combinations against Salmonella Typhimurium. results showed that lowest concentrations inhibiting growth S. Typhimurium significantly were 200, 400 mg/L, respectively. In a system combining different antimicrobials, treatments with cinnamaldehyde/thymol, cinnamaldehyde/carvacrol thymol/carvacrol revealed less population had synergy effect compared samples treated...
To identify synergistic combinations of different food additives, the antimicrobial effects thymol and carvacrol against Salmonella Typhimurium were assessed alone in combination with various other preservatives including EDTA, acetic acid, lactic citric acid. Overall, growth was significantly inhibited Mueller-Hinton broth containing thymol, carvacrol, or acid at concentrations 400 mg/liter, μl/liter, 300 0.2% (vol/vol), (wt/vol), respectively. The antimicrobials such as all resulted...