A5024017486- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Tryptophan and brain disorders
- Sesquiterpenes and Asteraceae Studies
- Pharmacological Effects of Medicinal Plants
- Long-Term Effects of COVID-19
- Ion Channels and Receptors
- Viral Infections and Immunology Research
- Phytochemical compounds biological activities
- Rheumatoid Arthritis Research and Therapies
- Biochemical Analysis and Sensing Techniques
- Neuroendocrine regulation and behavior
- Plant biochemistry and biosynthesis
- Transplantation: Methods and Outcomes
- Pulmonary Hypertension Research and Treatments
- Drug Transport and Resistance Mechanisms
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- Biochemical effects in animals
- Trace Elements in Health
- Inflammasome and immune disorders
China Medical University
2020-2024
Capsaicin (CAP) is an active ingredient in chili pepper that frequently consumed. It exerts various pharmacological activities, and also has potential effects on mental illness. However, its mechanism of antidepressant still unclear. Based the emerging perspective gut-brain axis, we investigated dietary CAP gut microbes mice with depression-like behaviors induced by lipopolysaccharide (LPS). C57BL/6J male (four weeks old) were given specific feed (standard laboratory chow or plus 0.005% CAP)...
Abstract Background Liquidambaris Fructus (LF) is the infructescence of Liquidambar formosana . In Traditional Chinese Medicine, LF has been used to treat joint pain, a common symptom arthritis and rheumatism; however, lack pharmacological evidence limited its applications in modern clinics. Therefore, this study aims explore protective effect on rheumatoid (RA) identify active ingredients. Methods Rats with adjuvant-induced (AIA) were divided into 4 groups administered petroleum ether...
Existing evidence demonstrates that coronavirus disease 2019 (COVID-19) leads to psychiatric illness, despite its main clinical manifestations affecting the respiratory system. People with mental disorders are more susceptible COVID-19 than individuals without coexisting health disorders, significantly higher rates of severe illness and mortality in this population. The incidence new diagnoses after infection acute syndrome 2 (SARS-CoV-2) is also remarkably high. SARS-CoV-2 has been reported...
Abstract Background Liquidambaris Fructus is the infructescences of Liquidambar formosana Hance and it has been used to treat some breast disease in Traditional Chinese Medicine. In previous study we found anti-breast cancer effect triterpenoid Fructus. This a further investigation triterpenoids aims identify their targets, meanwhile, estimate rationality traditional applications Methods Triterpenoids were isolated structures identified by NMR spectrums. Potential targets these predicted...
Abstract Osteoarthritis (OA) is a common degenerative joint disease characterized by articular cartilage destruction and synovial damage. The immune system has an impact on the development of OA. infiltration cells will cause autoimmune reaction osteoarthritis disrupt equilibrium in bone tissue. Recent studies have demonstrated that copper crucial regulating system. Copper can also mediate cell death through new program targeting tricarboxylic acid cycle (TCA) circulating protein. However,...
Abstract Background Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, and its exact etiology pathogenesis are still unclear by now, therefore it urgent to develop new therapeutic targets for RA treatment. Liquidambaris Fructus (LF) used joint pain, numbness edema, triterpenoids, the main effective compounds of LF, have clear anti-inflammatory effect. The aim this study was clarify mechanism triterpenoids from LF on treatment RA. Methods A comprehensive network...