A5063861321- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Liver Diseases and Immunity
- Silymarin and Mushroom Poisoning
- Pneumocystis jirovecii pneumonia detection and treatment
- Immunotherapy and Immune Responses
- Synthesis of heterocyclic compounds
- Neurological Disorders and Treatments
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Bioactive Compounds and Antitumor Agents
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Advanced biosensing and bioanalysis techniques
- Immune Response and Inflammation
- Synthesis of Indole Derivatives
- Liver Disease and Transplantation
- Cell death mechanisms and regulation
- Antibiotic Resistance in Bacteria
Anhui Medical University
2015-2024
First Affiliated Hospital of Anhui Medical University
2015-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2015-2023
China Pharmaceutical University
2018-2021
State Key Laboratory of Natural Medicine
2018
Farnesoid X receptor (FXR) is a promising target for nonalcoholic steatohepatitis (NASH) and fibrosis. Although various FXR agonists have shown anti-fibrotic effects in diverse preclinical animal models, the response rate efficacies clinical trials were not optimum. Here we report that prophylactic but therapeutic administration of obeticholic acid (OCA) prevents hepatic stellate cell (HSC) activation fibrogenesis. Activated HSCs show limited to OCA other due enhanced SUMOylation....
Obeticholic acid (OCA), the first FXR-targeting drug, has been claimed effective in therapy of liver fibrosis. However, recent clinical trials indicated that OCA might not be against fibrosis, possibly due to lower dosage reduce incidence side-effect pruritus. Here we propose a combinatory therapeutic strategy and apoptosis inhibitor for combating CCl
BackgroundHepatocyte is particularly vulnerable to apoptosis, a hallmark of many liver diseases. Although pro-apoptotic mechanisms have been extensively explored, less known about the hepatocyte-specific anti-apoptotic molecular events and it lacks effective approach combat hepatocyte apoptosis. We investigated effect mechanism farnesoid X receptor (FXR), strategies how target FXR for inhibiting apoptosis implicated in fibrosis.MethodsSensitivity was compared between wild type Fxr−/− mice...
Human NAD(P)H: quinone oxidoreductase (hNQO1) is an important biomarker for human malignant tumors. Detection of NQO1 accurately great significance to improve the early diagnosis cancer and prognosis patients. In this study, based on covalent assembly strategy, hNQO1-activated fluorescent probes 1 2 are constructed by introducing coumarin precursor 2-cyano-3-(4-(diethylamino)-2-hydroxyphenyl) acrylic acid self-immolative linkers. Under reaction with hNQO1 NADH, turn-on fluorescence appears...
Background Carbapenem-resistant gram-negative bacterial (CRGNB) infections are increasing among kidney transplant recipients, and effective therapeutic options limited. This study aimed to investigate the efficacy adverse events associated with combination therapy tigecycline in renal patients CRGNB infections. Methods retrospectively analyzed 40 Chinese confirmed or suspected who received therapy. The patients’ case features clinical microbiological data were analyzed. Results A total of...
Cirrhosis impairs macrophage function and disrupts bile acid homeostasis. Although acids affect in patients with sepsis, whether how the profile is changed by infection cirrhosis to modulate remains unclear. The present study aimed investigate changes of their effects on function. Serum was collected from 20 healthy subjects, 18 39 infection. Bile profiles were detected using high‑performance liquid chromatography‑triple time‑of‑flight mass spectrometer. association between analysed receiver...
Si-Ni-San (SNS), a traditional Chinese medicine, is effective in treating liver fibrosis with an unclear mechanism. Although disturbance of intestinal flora and the subsequent secretion short-chain fatty acids (SCFAs) suggested to be involved progression fibrosis, whether SNS produces anti-fibrosis effect through regulation SCFAs remains unclear.