Enantioselective intramolecular dearomative Heck reactions have been developed by Pd-catalyzed cross-coupling of aryl halides or triflates with the internal C═C bond indoles, benzofurans, pyrroles, and furans. A variety structurally unique spiroheterocycles benzofused heterocycles having N/O-substituted quaternary carbon stereocenters, exocyclic olefin moieties were afforded in moderate to excellent yields good enantioselectivities, showing a broad scope present protocol. series new BINOL-...

Abstract A highly efficient palladium‐catalyzed disilylation reaction of aryl halides through C−H activation has been developed for the first time. The broad substrate scope. variety can be disilylated by three types activation, including C(sp 2 )−H, 3 and remote activation. In particular, reactions are also unusually efficient. yields essentially quantitative in many cases, even presence less than 1 mol % catalyst equivalent silylating reagent under relatively mild conditions. biphenyls...

An approach for the synthesis of spirooxindoles has been developed <italic>via</italic> palladium-catalyzed remote C–H functionalization with CH₂Br₂.

Utilizing halogens as traceless directing goups represents an attractive strategy for C-H functionalization. A two alkylation system, initiated by the oxidative addition of organohalides to Pd0 , has been developed. The first reaction involves intermolecular palladacycles form C(sp3 )-C(sp2 ) bonds followed C(sp2 )-H activation/cyclization deliver alkylated benzocyclobutenes final products. In second reaction, C-C are formed with CH2 Br2 and provides a facile efficient method synthesis...

Tetraphenylenes not only are theoretically and experimentally interesting but also have potential applications in a variety of fields such as materials science, supramolecular chemistry, asymmetric catalysis. A facile efficient approach is reported for the syntheis tetraphenylene its derivatives from 2-iodobiphenyls via Pd-catalyzed C–H activation. range substituted tetraphenylenes can be synthesized using this method, reaction performed on gram scale with relatively high efficiency,...

A Pd-catalyzed enantioselective intramolecular carbonylative Heck reaction has been developed by using formate esters as the source of CO.

Dearomative functionalization reactions represent an important strategy for the synthesis of valuable three-dimensional molecules from simple planar aromatics. Naphthalene is a challenging arene towards transition-metal-catalyzed dearomative difunctionalization reactions. Reported herein application naphthalene as masked conjugated diene in palladium-catalyzed 1,4-diarylation or 1,4-vinylarylation reaction via tandem Heck/Suzuki sequence. Three types 1,4-dihydronaphthalene-based spirocyclic...

Abstract A facile and efficient approach has been developed for the synthesis of carbazoles from 2‐iodobiphenyls diaziridinone under palladium catalysis. wide range were synthesized in good to excellent yields, indole derivatives obtained by using styrenes as substrate. The palladacycles acted key intermediate, reaction should proceed via a tandem Pd‐catalyzed C−H activation/dual C−N bond formation sequence. magnified image

The three-component reaction of aryl iodides, alkynes, and diaziridinone is described. provides an innovative synthetic approach for indoles. features high efficiency, broad substrate scope, excellent regioselectivity. C,C-Palladacycles should act as the intermediates. C,C-palladacycles are obtained from simple halides alkynes then reacted with to afford

An efficient palladium-catalyzed hydroxycarbonylation reaction of arylhalides using oxalic acid as a CO source has been developed. The features high safety, low catalyst loading, and broad substrate scope, provides safe tractable approach to access variety aromatic carboxylic compounds. Mechanistic studies revealed the decomposition pattern acid.

A palladium-catalyzed sequential three-component reaction has been developed. The palladacycles, generated through cascade reactions of aryl halides and alkynes, are the key intermediates react with hexamethyldisilane to form disilylated products. represents a useful preparative method for vinylsilanes, vinylsilanes can be transformed into tetrasubstituted alkenes.

Abstract magnified image An efficient and mild iron‐catalyzed synthesis of alkenyl halides has been developed via direct carbon‐carbon bond formation by using benzyl arylalkynes.

With the employment of a threonine-incorporating multifunctional catalyst 9, Michael addition 3-sulfenyloxindoles to nitroolefins proceeded stereoselectively, leading formation oxindoles with 3-sulfenyl-substituted quaternary center in excellent yields, and high diastereoselectivities enantioselectivities.

Abstract A highly efficient palladium‐catalyzed disilylation reaction of aryl halides through C−H activation has been developed for the first time. The broad substrate scope. variety can be disilylated by three types activation, including C(sp 2 )−H, 3 and remote activation. In particular, reactions are also unusually efficient. yields essentially quantitative in many cases, even presence less than 1 mol % catalyst equivalent silylating reagent under relatively mild conditions. biphenyls...

Abstract An approach for the synthesis of benzofulvenes has been developed through palladium‐catalyzed sequential three‐component reactions. The reactions likely involve C , ‐palladacycles as key intermediates. palladacycles are generated cascade aryl halides and alkynes, then reacted with CH 2 Br to form final products. magnified image

Abstract An efficient approach for the synthesis of benzimidazoles has been developed through Pd‐catalyzed amination 2‐iodobenzimines with diaziridinone. A wide range 2‐(hetero)aryl benzimidazloes are synthesized in good to excellent yields. The reactions likely involve C , ‐palladacycles derived from as key intermediate, and palladacycles reacted diaziridinone form benzimidazoles. magnified image

Abstract Utilizing halogens as traceless directing goups represents an attractive strategy for C−H functionalization. A two alkylation system, initiated by the oxidative addition of organohalides to Pd 0 , has been developed. The first reaction involves intermolecular palladacycles form C(sp 3 )−C(sp 2 ) bonds followed )−H activation/cyclization deliver alkylated benzocyclobutenes final products. In second reaction, C−C are formed with CH Br and provides a facile efficient method synthesis...

Open AccessCCS ChemistryCOMMUNICATION1 Sep 2021Stereoselective 1,2-Dicarbofunctionalization of Trisubstituted Alkenes by Palladium-Catalyzed Heck/Suzuki or Heck/Sonogashira Domino Sequence Jia-Wen Zhu, Bo Zhou, Zhong-Yan Cao, Ren-Xiao Liang and Yi-Xia Jia Zhu College Chemical Engineering, Zhejiang University Technology, Hangzhou 310014 , Zhou Cao *Corresponding author: E-mail Address: [email protected] State Key Laboratory Organometallic Chemistry, Shanghai Institute Organic Chinese Academy...

The structural composition of reduced graphene oxide (rGO) can be modified and controlled by appropriate reduction methods to modulate its electronic structure, rendering it a versatile platform for tailoring optoelectronic catalytic properties. Nevertheless, is uncommon concurrently amplify the photocatalytic photothermal effects when regulating utilizing pure rGO. Here, we investigate impact variations in thermally (TGO) on Various characterization results demonstrate that thermal...

Atherosclerosis (AS) is a critical pathological event during the progression of cardiovascular diseases. It exhibits fibrofatty lesions on arterial wall and lacks effective treatment. N6-methyladenosine (m6A) most common modification eukaryotic RNA plays an important role in regulating development However, m6A AS remains largely unknown. Therefore, this study, we explored transcriptome distribution its potential mechanism.Methylation Quantification Kit was used to detect global levels aorta...