A5030986536- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Hippo pathway signaling and YAP/TAZ
- Immune cells in cancer
- Cancer Cells and Metastasis
- Nanoplatforms for cancer theranostics
- Cellular transport and secretion
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Cannabis and Cannabinoid Research
- Nanoparticle-Based Drug Delivery
- Genomics, phytochemicals, and oxidative stress
- Lattice Boltzmann Simulation Studies
- T-cell and Retrovirus Studies
- 3D Printing in Biomedical Research
- ATP Synthase and ATPases Research
Fourth Affiliated Hospital of China Medical University
2017-2025
China Medical University
2017-2025
Emerging evidence indicates that tumor cells release a large amount of exosomes loaded with cargos during tumorigenesis. Exosome secretion is multi-step process regulated by certain related molecules. Long non-coding RNAs (lncRNAs) play an important role in hepatocellular carcinoma (HCC) progression. However, the lncRNA HOTAIR regulating exosome HCC remains unclear. We analyzed relationship between expression and secretion-related genes using gene set enrichment analysis (GSEA). Nanoparticle...
Abstract After undergoing metabolic reprogramming, tumor cells consume additional glutamine to produce amino acids, nucleotides, fatty and other substances facilitate their unlimited proliferation. As such, the metabolism of is intricately linked survival progression cancer cells. Consequently, targeting presents a promising strategy inhibit growth cell development. This review describes uptake, metabolism, transport in its pivotal role biosynthesis more. Furthermore, we have also summarized...
Abstract Long noncoding RNAs (lncRNAs) has been acknowledged in tumorigenesis gradually because of the great importance different cancers. LncRNA nuclear enriched abundant transcript 1 (NEAT1) is a novel lncRNA and reported to promote multiple cancer progression. However, biological roles NEAT1 hepatocellular carcinoma (HCC) not cleared nowadays. In present research, level was found be upregulated HCC by The Cancer Genome Atlas. addition, expression negatively correlated with survival rate...
Sorafenib is a multi-kinase inhibitor that used as standard treatment for advanced hepatocellular carcinoma (HCC). However, the mechanism of sorafenib resistance in HCC still unclear. It has been shown CISD2 expression related to progression and poor prognosis HCC. Here, we show new role HCC.Bioinformatic analysis was detect negative regulatory genes ferroptosis sorafenib-resistant samples. The concentration gradient method establish cells. Western blot protein CISD2, LC3, ERK, PI3K, AKT,...
Tumor cells are known to release large numbers of exosomes containing active substances that participate in cancer progression. Abnormally expressed long noncoding RNAs (lncRNAs) have been confirmed regulate multiple processes associated with tumor However, the mechanism by which lncRNAs affect exosome secretion remains unclear.The underlying mechanisms RNA LINC00511 (LINC00511) regulation multivesicular body (MVB) trafficking, secretion, invadopodia formation, and invasion were determined...
Extracellular vesicles (EVs) have been the subject of an exponentially growing number studies covering their biogenesis mechanisms, isolation and analysis techniques, physiological pathological roles, clinical applications, such as biomarker therapeutic uses. Nevertheless, heterogeneity EVs both challenges our understanding them presents new opportunities for potential application. Recently, EV field experienced a wide range advances. However, also remain huge. This review focuses on recent...