A5100773927- Pharmacological Effects of Natural Compounds
- Listeria monocytogenes in Food Safety
- Computational Drug Discovery Methods
- Gut microbiota and health
- Cancer Mechanisms and Therapy
- Gastric Cancer Management and Outcomes
- Chronic Kidney Disease and Diabetes
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Advanced DC-DC Converters
- Ginseng Biological Effects and Applications
- RNA modifications and cancer
- Tannin, Tannase and Anticancer Activities
- 2D Materials and Applications
- Natural product bioactivities and synthesis
- Microbial Metabolites in Food Biotechnology
- Advanced Chemical Sensor Technologies
- Microgrid Control and Optimization
- Robotic Locomotion and Control
- Food composition and properties
- Phytochemistry and Biological Activities
- Cancer survivorship and care
- Food Supply Chain Traceability
- Advanced Memory and Neural Computing
- Phytochemical Studies and Bioactivities
Dalian Polytechnic University
2021-2025
Beijing Institute of Petrochemical Technology
2025
Guang’anmen Hospital
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Xinjiang Technical Institute of Physics & Chemistry
2023-2025
University of Chinese Academy of Sciences
2025
Wuhan University
1997-2024
University of Science and Technology of China
2023-2024
Chinese General Hospital College of Nursing and Liberal Arts
2024
Chinese People's Liberation Army
2024
The mechanisms underlying the therapeutic effect of Salvia miltiorrhiza (SM) on diabetic nephropathy (DN) were examined using a systematic network pharmacology approach and molecular docking. Traditional Chinese Medicine Systems Pharmacology (TCMSP) database was used to screen active ingredients SM. Targets obtained SwissTargetPrediction TCMSP databases. Proteins related DN retrieved from GeneCards DisGeNET A protein-protein interaction (PPI) constructed common SM/DN targets in Search Tool...
As a novel family of 2D materials, MXenes are supposed to play vital role in optoelectronic devices and systems due their high conductivity, good optical properties, favorable compatibility with water organic solvents. However, the application highly sensitive photodetection is far scarcely investigated. Here, we demonstrate high-quality Ti3C2Tx/GaAs Schottky junction by simply dripping Ti3C2Tx MXene solution on pre-patterned GaAs substrate. Owing wide absorption quality junction,...
The suppressive tumour microenvironment significantly hinders the efficacy of immunotherapy in treating solid tumors. In this context, stromal cells, such as tumour-associated fibroblasts, undergo changes that include an increase number and function immunosuppressive cells. Adenosine, a factor promotes growth, is produced from ATP breakdown markedly elevated microenvironment. It acts through specific binding to adenosine receptors, with A2A A2B receptor being primary drivers...
Gegen Qinlian Decoction (GQD) is a Chinese herbal medicine that has been reported to significantly decrease blood glucose levels, which suggested be related interactions with the gut microbiota. However, protective effect of GQD on intestinal barrier function regard its influence microbiota not explored date. In this study, we investigated role in mediating hypoglycemic mechanism type 2 diabetes mellitus (T2DM) rats induced by single intraperitoneal injection streptozotocin after 4 weeks...
Phenolipids such as hydroxytyrosol-SCFA acyl esters (HTy-SEs) and tyrosol-SCFA (TYr-SEs) with various alkyl chains lengths (C1-C4) different isomers (branched-chain straight-chain) were successfully synthesized. All hydrolyzed by pancreatic lipase to produce polyphenols (HTy TYr) SCFAs (iso-butyric acid, acetic propionic n-butyric acid). Moreover, HTy-SEs (and TYr-SEs) could also be free HTy gut microbiota Lactobacillus from mice feces. Especially, the hydrolysis rates showed positive...
Introduction Postoperative recurrence and metastasis of gastric cancer (GC) are primary factors that contribute to poor prognosis. GC recurs at a rate approximately 70%–80% within 2 years after local treatment 90% 5 years. “ Yang-deficient toxic node ” is the core pathogenesis metastasis. The Yiqi Wenyang Jiedu prescription (YWJP), form complementary alternative medicine in China, an empirical remedy prevent postoperative GC. Taking main therapeutic principles “nourishing Qi warming Yang ,...
Background: The incidence and mortality of lung cancer is the highest among malignant tumors worldwide, it seriously threatens human life health. Surgery primary radical treatment for cancer. However, patients often experience discomfort, changes in social roles, economic pressures, other postsurgical challenges. These factors frequently cause various psychological disorders such as anxiety depression, significantly diminishing quality elevating risks recurrence, metastasis, mortality....
Epigenetic reprogramming is involved in multiple steps of human cancer evolution and mediated by a variety chromatin-modifying enzymes. Specifically, the histone lysine methyltransferase KMT2D among most frequently mutated genes oral squamous cell carcinoma (OSCC). However, mechanisms which affects development OSCC remain unclear.In present study, we found that expression was elevated compared to paracancerous specimens correlated with more advanced tumor grade. More importantly, knockdown...
Metabolic reprogramming is a hallmark of human cancer. Cancer cells exhibit enhanced glycolysis, which allows glycolytic intermediates to be diverted into several other biosynthetic pathways, such as serine synthesis. Here, we explored the anti-cancer effects pyruvate kinase (PK) M2 inhibitor PKM2-IN-1 alone or in combination with phosphoglycerate dehydrogenase (PHGDH) NCT-503 NSCLC A549 vitro and vivo. inhibited proliferation induced cell cycle arrest apoptosis, increased intermediate...