A5100325319- Mycobacterium research and diagnosis
- Regional Development and Environment
- Impact of Technology on Adolescents
- Child Development and Digital Technology
- Geographic Information Systems Studies
- MicroRNA in disease regulation
- Tuberculosis Research and Epidemiology
- Single-cell and spatial transcriptomics
- Advanced Computational Techniques and Applications
- Technology Adoption and User Behaviour
- Advanced Computing and Algorithms
- Diagnosis and treatment of tuberculosis
- Advanced Biosensing Techniques and Applications
- Perfectionism, Procrastination, Anxiety Studies
- RNA Interference and Gene Delivery
- China's Ethnic Minorities and Relations
- Evolving Legal Systems and Governance
- Transportation Planning and Optimization
- Cultural Industries and Urban Development
- Antimicrobial Peptides and Activities
- Legal principles and applications
- Regional Socio-Economic Development Trends
- Cardiac Imaging and Diagnostics
- Urban Transport and Accessibility
- Vehicle Routing Optimization Methods
Shanghai Public Health Clinical Center
2018-2025
Zhengzhou University
2022-2023
Qinhuangdao Second Hospital
2022
Beijing Jiaotong University
2021
PLA Information Engineering University
2010-2021
Huazhong Agricultural University
2020
China University of Geosciences
2018
Hebei Agricultural University
2016
Jilin University
2014
Union Hospital
2014
Lung inflammation indicated by 18F-labeled fluorodeoxyglucose (FDG) in patients with tuberculosis is associated disease severity and relapse risk upon treatment completion. We revealed the heterogeneity intercellular crosstalk lung tissues 18F-FDG avidity adjacent uninvolved from 6 single-cell RNA-sequencing. Tuberculous lungs had an influx of regulatory T cells (Treg), exhausted CD8 cells, immunosuppressive myeloid conventional DC, plasmacytoid neutrophils. Immune inflamed showed general...
Objective This study aims to screen common immunological markers of lung tissues and blood for diagnosis tuberculosis (TB). Methods Differentially expressed miRNAs (DEmRs) mRNAs (DEGs) were obtained by whole-transcriptome sequencing profiles on 18F-FDG PET/CT high low metabolic active regions in nine TB patients. Common screened intersecting with DEmRs, four miRNA GEO datasets, their target predicted through the miRTarbase Tarbase databases. Then these intersected DEGs, from samples...
Large-scale strain (i.e., large in wide-range optical fiber) distorts distance referencing spectrum-based frequency-domain reflectometry (OFDR), resulting severe position segment mismatches and degraded accuracy. In this letter, a reposition method (DRM) is proposed, which employs femtosecond-laser-inscribed permanent scatter (PS) array as in-fiber reference markers. By realigning adjacent fiber segments to repositioned PS positions, the DRM enables sufficient self-correction against...
Tuberculosis-affected lungs with chronic inflammation harbor abundant immunosuppressive immune cells but the nature of such is unclear. Dysfunction in T cell exhaustion, while implicated inflammatory diseases, remains unexplored tuberculosis. Given that immunotherapy targeting exhaustion checkpoints exacerbates tuberculosis, we speculate dysfunctional Using integrated single-cell RNA sequencing and receptor profiling reported defects responses within inflamed tuberculosis-affected lungs....
Abstract Background In recent years, there have been frequent reports of gaming disorder in China, with more focus on young people. We developed and psychometrically tested a Gaming Disorder screening scale (i.e., Screening Scale - GDSS) for Chinese adolescents adults, based the existing scales diagnostic criteria, but also considering development status China. Methods For testing content criterion validity, 1747 participants competed GDSS Internet Addiction Test (IAT). After 15 days, 400...
The traditional wired seismograph has disadvantages such as cumbersome cable, complicated wiring, crosstalk and noise between adjacent transmission lines. In addition, the dynamic range of instrument is small, observation seismic signals not intuitive, which can meet needs high-precision exploration. order to solve these problems, design distributed three component data acquisition system based on LoRa wireless communication technology proposed. uses long-distance 24 bit Σ-Δ ADC, realizes...
摘要:
Accurate diagnosis of complete inactivation tuberculosis lesions is still a challenge with respect to sputum-negative tuberculosis. RNA-sequencing was conducted uncover potential lncRNA indicators metabolic activity in lesions. Lung tissues high and low demonstrated by fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography were collected from five patients for RNA-sequencing. Differentially-expressed mRNAs lncRNAs identified. Their correlations evaluated construct...
Improving the understanding of molecular mechanism tuberculous pleurisy is required to develop diagnosis and new therapy strategies targeted genes. The purpose this study identify important genes related pleurisy. In study, expression profile obtained by sequencing surgically resected pleural tissue was used explore differentially co-expressed between normal tissue. 29 were screened weighted gene co-expression network analysis (WGCNA) differential methods. According functional annotation R...
Abstract Reasonable districting plays an important role in the patrolling process. In this paper, workload attributes are considered, and a mixed integer programming model is developed to solve street patrol problem (SPDP). The improved spectral clustering algorithm named based on road network (SCRn) simulated annealing (SA) combined. This results hybrid called SCRn-SA. SCRn-SA tested small examples real instances Zhengzhou, China. experimental show that proposed effective for solving SPDP....
The development of mobile Internet technology makes people break away from the time and space restrictions, enables them to interact with each other who bought same brand as they do or will buy products services a through online virtual community. Mi Community is taken an example in this study. theories community, interactivity community consumer behavior are introduced, theoretical model that reflects impact communities on built illustrate process promoting behavior.
The change of international political situation caused by the geopolitical conflict has been an important factor that influencing division world order. This paper analyzes main trends order reconstruction in recent years under perspective geopolitics. In process reviewing geographical issues major powers and hotspots , research found is taking Eurasia as core geographically, based on Seven Powers a influence have inside, outside balances interdependence global power system. there were many...
Receptor for hyaluronic acid (HA)‑mediated motility (RHAMM) expression is upregulated in pancreatic ductal adenocarcinoma (PDAC). In the present study, small interfering RNA knockdown was used to investigate regulatory mechanism and function of RHAMM PDAC cells. Reverse transcription‑quantitative PCR measure mRNA levels RHAMM, hyaluronan synthases (HAS1, HAS2 HAS3) hyaluronidases (HYAL1, HYAL2 HYAL3) eight cell lines. Cell migration assessed using a Transwell assay, while HA concentration...
Background: The number of HIV-infected patients with non-small-cell lung cancer (NSCLC) undergoing surgical treatment has been increasing recently. However, the risk factors for postoperative complications and reliable predictive long-term survival remain to be unclear. This study aimed investigate complications, prognostic in NSCLC.Methods: NSCLC who underwent were retrospectively studied; a single-institutional analysis was conducted from November 2011 August 2018. Preoperative clinical...
In the face of ageing population and coordinated development strategy Beijing-Tianjin-Hebei region, region endowment small town exists following problems: mode single, existing polarization between regions, low level services, inadequate planning, etc. Taking Shunping county in hebei province as an example, this paper puts forward towns multi-factors coordination planning region.That is industry system building rendering guide, diversificate pattern building, space hierarchical layout,...
Osteosarcoma(OS) is the most common primary bone tumors that endangers children and adolescent challenges medical community because of its poor prognosis metastasis.Currently,abundant literatures have reported immunotherapy could enhance antitumor immune response inhibit tumor growth,metastasis to some extent.This review summarized recent reports expectation on clinical outcome in future. Key words: Osteosarcoma; Adoptive immunotherapy; Active
In the paper, generalized toponym ontology(GTO) is constructed and consummate d by use of topography vocabulary correlative nation standards. The ontology us ed to classify encode information, spatial topology relations reasoning based on Jena knowledge retrieval. GTO future development trend ponym science it will be massy base intellective services semantic web.
In this paper, the highly immunogenic genes Ag85b, Rv3872, CFP10, and ESAT6 of Mycobacterium tuberculosis were expressed tandemly integrated into carrier pTIC6a, recombinant plasmid...