A5032500874- Breast Lesions and Carcinomas
- Cancer-related molecular mechanisms research
- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Cancer and Skin Lesions
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Galectins and Cancer Biology
- Phytochemistry and Bioactive Compounds
- Radiomics and Machine Learning in Medical Imaging
- Endometrial and Cervical Cancer Treatments
- Heat shock proteins research
- Adrenal and Paraganglionic Tumors
- Cancer therapeutics and mechanisms
- HER2/EGFR in Cancer Research
- Breast Implant and Reconstruction
- Genomics, phytochemicals, and oxidative stress
- Neurobiology and Insect Physiology Research
Capital Medical University
2009-2023
Wuhan University
2009-2021
Renmin Hospital of Wuhan University
2019-2021
The University of Texas MD Anderson Cancer Center
2009-2018
Chengdu Fifth People's Hospital
2018
Merck Serono (Italy)
2018
Bristol-Myers Squibb (Germany)
2018
AstraZeneca (Brazil)
2018
OncoMed (United States)
2018
Merck (Germany)
2018
Polypyrimidine tract-binding protein 1 (PTBP1) is a multi-functional RNA-binding that aberrantly overexpressed in glioma. PTBP1 and its brain-specific homologue polypyrimidine 2 (PTBP2) regulate neural precursor cell differentiation. However, the overlapping non-overlapping target transcripts involved this process are still unclear. To determine why not PTBP2 would promote glial cell-derived tumours, both were knocked down human glioma lines U251 LN229 to role of these proteins...
Aberrant RNA splicing is thought to play a key role in tumorigenesis. The assessment of its specific contributions limited by the complexity information derived from genome-wide array-based approaches. We describe how performing factor-specific comparisons using both tumor and cell line data sets may more readily identify physiologically relevant tumor-specific events. Affymetrix exon array glioblastoma (GBM) samples with defined polypyrimidine tract-binding protein 1 (PTBP1) levels were...
Interpretation of calcitonin measurement to predict the prognosis medullary thyroid carcinoma (MTC) requires multiple measurements over an extended time period, making it imperfect biomarker for evaluating or disease behavior. Single circulating cell-free DNA (cfDNA) values have been shown be a valuable prognostic marker several solid tumors. We tested hypothesis that cfDNA containing RET M918T mutation could detected in blood patients with advanced MTC whose tumor harbored and would able...
Adrenocortical carcinoma is a rare malignancy with poor prognosis and limited response to chemotherapy. Hepatocyte growth factor (HGF) its receptor cMET augment cancer resistance chemotherapy, but their role in adrenocortical has not been examined. In this study, we investigated the association between HGF/cMET expression hallmarks of carcinoma. Transcriptomic immunohistochemical analyses indicated that increased human samples was positively associated cancer-related biologic processes,...
The cyclin-dependent-kinase inhibitors (CDKN)/retinoblastoma (RB1) pathway has been implicated as having a role in medullary thyroid carcinoma (MTC) tumorigenesis. CDKN2C loss associated with RET-mediated MTC humans but minimal phenotypic correlation provided. objective of this study was to evaluate the association between tumor RET mutation status, loss, and aggressiveness cohort patients sporadic disease.Tumors from treated at single institution were evaluated for somatic RETM918T copy...
Recently, emerging evidence has suggested that carcinoma-associated fibroblasts (CAFs) could contribute to chemotherapy resistances in breast cancer treatment. The aim of this study is compare the gene expression profiling CAFs before and after pick up candidate genes might associate with resistance be used as predictors treatment response. were cultured from surgically resected primary cancers identified immunohistochemistry (IHC) Flow cytometry (FCM). MDA-MB-231 cells cell line. Cell...
OBJECTIVE: Breast cancer is a common malignancy in women and long non-coding RNAs (lncRNAs) have been shown to play key roles the development progression of breast cancer. In present study, we examined biological role lncRNA gastric carcinoma highly expressed transcript 1 (GHET1) METHODS: The expression GHET1 was determined by qRT-PCR assay; CCK-8, colony formation, Transwell invasion migration assays detected cell proliferation, migration; apoptosis cycle were flow cytometry; protein levels...
Purpose Anaplastic thyroid cancer (ATC) is a deadly form of cancer. BRAF V600E the only actionable mutation for which there Food and Drug Administration–approved drug combination. Rapid detection initiation therapy critical. We explored ability droplet digital polymerase chain reaction (ddPCR) to identify this in circulating cell-free DNA (cfDNA) plasma. Materials Methods The ddPCR assay was evaluated its sensitivity, specificity cfDNA, concordance with tumor tissue. also used evaluate...
Objective: Long non-coding RNAs (lncRNAs) are a new class of noncoding RNAs, which serve as crucial regulators in tumor progression, including osteosarcoma (OS). The objective this study is to uncover the clinical significance and biological role lncRNA CDKN2B antisense RNA 1 (CDKN2B-AS1) OS. Methods: Quantitative real time PCR analysis was used determine expression CDKN2B-AS1 OS tissues cell lines. associations between clinicopathological characteristics patients were assessed by...
Although miRNA-183-5p plays a critical role in many cancer types, including gastric cancer, hepatocellular carcinoma, prostate renal cell and breast its osteosarcoma remains unclear. Expression levels of miR-183-5p were detected tissues lines using qRT-PCR. The effect on the survival recurrence patients was analyzed cohort 80 Kaplan-Meier curves Cox regression analysis. Effects proliferation, migration invasion abilities evaluated CCK-8, crystal violet transwell assays. expression found to...
Rationale: Metaplastic breast carcinoma (MBC) is rare subtype of and regarded as ductal that undergoes metaplasia into a glandular growth pattern. Spindle cell (SPC) MBC with predominant spindle component. Patient concerns: The patient was 52-year-old female invasive who underwent modified radical mastectomy an axillary node dissection. A new lump observed underneath the surgical site between pectoralis major minor muscles 45 days after sequential postoperative chemotherapy radiotherapy....
Objective To explore the extent of axillary lymph node dissection in breast cancer patients with positive sentinel nodes.Methods In this series,95 underwent complete (CALND) following nodes identified and 97 partial (PALND) at absence nodes.The influence different was evaluated.Results The rate level(Ⅰ + Ⅱ) non-sentinel (NSLN) level Ⅲ 68.4％ 29.5％,respectively,in CALND group.In PALND situation,57.9％ cases would have changed pathologic stage from pN1 to pN2 or pN3.But followed PALND,only 2.1％...
Medullary thyroid carcinoma (MTC) is a cancer of the parafollicular C cells commonly caused by an inherited or acquired RET protooncogene mutation. Therapeutic resistance and recurrence disease imply presence stem in MTC. In this study, we sought to identify characterize cell-like The characterization cell properties was performed using immunostaining, flow cytometry, sphere formation assay, rederivation Western blotting, quantitative RT-PCR defined markers neural progenitor cells. role...