A5082270382- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- HIV Research and Treatment
- Cancer-related gene regulation
- Renal cell carcinoma treatment
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Liver physiology and pathology
- Natural product bioactivities and synthesis
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Pancreatic function and diabetes
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Cytokine Signaling Pathways and Interactions
- Tuberculosis Research and Epidemiology
- Single-cell and spatial transcriptomics
- Cytomegalovirus and herpesvirus research
- Contact Dermatitis and Allergies
- Biological Activity of Diterpenoids and Biflavonoids
- Cancer Immunotherapy and Biomarkers
- Hepatitis C virus research
- Marine Sponges and Natural Products
- Genetics and Neurodevelopmental Disorders
Shenzhen University
2019-2025
Xi'an University of Technology
2024
Shenzhen University Health Science Center
2019-2023
University of Iowa
2015-2019
302 Military Hospital of China
2007-2012
Changhai Hospital
2011
Second Military Medical University
2011
National Institute for Communicable Disease Control and Prevention
2007-2010
Institute of Biophysics
2008-2010
Chinese Academy of Sciences
2008-2010
Cancer theranostics based on glucose oxidase (GOx)-induced starvation therapy has got more and attention in cancer management.Herein, GOx armed manganese dioxide nanosheets (denoted as MNS-GOx) were developed nanotheranostic agent for magnetic resonance (MR)/photoacoustic (PA) dual-modal imaging guided self-oxygenation/hyperthermia dually enhanced therapy.The nanomaterials with different morphologies (such nanoflowers, nanowires) synthesized by a biomimetic approach using melanin...
Abstract The role of CD4 + cytotoxic T cells (CTLs) in hepatocellular carcinoma (HCC) remains obscure. This study characterized CTLs HCC patients and further elucidated the associations between disease progression. In all, 547 patients, 44 chronic hepatitis B (CHB) 86 liver cirrhosis (LC) 88 healthy individuals were enrolled study. defined by flow cytometry, immunohistochemistry, lytic granule exocytosis assays. A multivariate analysis prognostic factors for overall survival was performed...
Tuberculosis (TB) continues to be a critical global health problem, which killed millions of lives each year. Certain circulating cell subsets are thought differentially modulate the host immune response towards Mycobacterium tuberculosis (Mtb) infection, but nature and function these is unclear.Peripheral blood mononuclear cells (PBMC) were isolated from healthy controls (HC), latent infection (LTBI) active then subjected single-cell RNA sequencing (scRNA-seq) using 10 × Genomics platform....
Tcf1 and Lef1 have versatile functions in regulating T cell development differentiation, but intrinsic requirements for these factors regulatory (T reg) cells remain to be unequivocally defined. Specific ablation of reg resulted spontaneous multi-organ autoimmunity that became more evident with age. Tcf1/Lef1-deficient regs showed reduced protection against experimentally induced colitis, indicative diminished immuno-suppressive capacity. Transcriptomic analysis revealed were responsible...
Abstract In response to acute viral infection, activated naive T cells give rise effector that clear the pathogen and memory persist long-term provide heightened protection. cell factor 1 (Tcf1) is essential for several of these differentiation processes. Tcf1 expressed in multiple isoforms, with all isoforms sharing same HDAC DNA-binding domains long containing a unique N-terminal β-catenin–interacting domain. this study, we specifically ablated mice, while retaining expression short...
Ezh2 is an histone methyltransferase (HMT) that catalyzes H3K27me3 and functions in TH1, TH2, Treg cells primarily via HMT activity. Here we show ablation impairs T follicular helper (TFH) cell differentiation activation of the TFH transcription program. In cells, most Ezh2-occupied genomic sites, including Bcl6 promoter, are associated with H3K27ac rather than H3K27me3. Mechanistically, recruited by Tcf1 to directly activate transcription, this function requiring phosphorylation at Ser21....
Abstract Post‐surgical tumor recurrence remains a major clinical concern for patients with malignant solid tumors. Herein, an immunotherapeutic hydrogel (SA PBA /ZMC/ICG) is developed by incorporating metal ion‐cyclic dinucleotide (CDN) nanoparticles (Zn‐Mn‐CDN, ZMC) and photosensitizer (indocyanine green, ICG) into phenylboronic acid (PBA)‐conjugated sodium alginate ) photothermal therapy (PTT)‐triggered in situ vaccination to inhibit post‐surgical metastasis of The gelation SA /ZMC/ICG the...
Beyond the antimicrobial activity, doxycycline (DOX) exhibits longevity-promoting effect in nematodes, while its on mammals is unclear. Here, we applied a mouse model of Hutchinson-Gilford progeria syndrome (HGPS), Zmpste24 knockout (KO) mice, and analyzed antiaging DOX. We found that DOX treatment prolongs lifespan ameliorates progeroid features KO including decline body tissue weight, exercise capacity cortical bone density, shortened colon length. alleviates abnormal nuclear envelope...
Persistent HIV infection results in a decrease absolute counts of CD4(+) CD25(+) regulatory T cells (Treg). To investigate the role decreased Treg regulation excessive activation and apoptosis CD8(+) human immunodeficiency virus (HIV)-1 infection, we characterized 83 HIV-1-infected individuals, including 19 long-term non-progressors (LTNPs) 51 typical progressors (TPs) who were treatment-naïve, 13 AIDS patients on highly active antiretroviral therapy (HAART), whom nine complete responders...
The hepatic acute-phase response is characterized by a massive upregulation of serum proteins, such as haptoglobin and amyloid A, at the expense liver homeostatic functions. Although transcription factor hepatocyte nuclear 4 alpha (HNF4A) has well-established role in safeguarding function its cistrome spans around 50% liver-specific genes, received little attention so far. We demonstrate that HNF4A binds to represses genes under basal conditions. reprogramming during inflammation...
Tle/Groucho proteins are transcriptional corepressors interacting with Tcf/Lef and Runx transcription factors, but their physiological roles in T cell development remain unknown. Conditional targeting of Tle1, Tle3 Tle4 revealed gene dose–dependent requirements for Tle CD8 + lineage cells. Upon ablating all three proteins, generation cells was greatly diminished, largely owing to redirection MHC-I–selected thymocytes CD4 lineage; the remaining CD8-positive showed aberrant up-regulation...
In vivo real-time monitoring gastric acid is of great importance for diagnosis and treatment gastrointestinal diseases. Herein, we synthesized a pH-responsive photoacoustic (PA) nanoprobe (denoted as LET-4) based on near-infrared (NIR) dye (IR1061) in imaging (PAI) living subjects. the acidic condition, protonated LET-4 has strong absorbance peak at 808 nm, followed by PA signal output nm. The PA808 pH 3 3.45-fold higher than 7. More importantly, could monitor secretion assessment animal...
Sepsis is a life-threatening medical emergency triggered by excessive inflammation in response to an infection. High mortality rates and limited therapeutic options pose significant challenges sepsis treatment. Histone deacetylase inhibitors (HDACi), such as suberoylanilide hydroxamic acid (SAHA), have been proposed potent anti-inflammatory agents for treating inflammatory diseases. However, the underlying mechanisms of treatment remain poorly understood. In this study, we investigated...
To characterize the homeostasis of CD4FoxP3 regulatory T cells (Treg) and its association with immune hyperactivation in disease progression chronic HIV-1 infection.Treg proliferation apoptosis markers were determined relation to Treg activation was analyzed.Fifty-six HIV-1-infected highly active antiretroviral therapy (HAART)-naive subjects 17 HAART-treated enrolled. Proliferation from peripheral blood evaluated by intracellular Ki-67 caspase-3 or surface Annexin-V staining. T-cell markers,...