A5090796277- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- vaccines and immunoinformatics approaches
- Effects of Radiation Exposure
- Listeria monocytogenes in Food Safety
- Adrenal Hormones and Disorders
- Nitric Oxide and Endothelin Effects
- Clostridium difficile and Clostridium perfringens research
- Immune responses and vaccinations
- Gut microbiota and health
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Single-cell and spatial transcriptomics
- COVID-19 Clinical Research Studies
- Dermatology and Skin Diseases
- Autoimmune and Inflammatory Disorders Research
- Inflammation biomarkers and pathways
University of Iowa
2016-2025
Harborview Medical Center
2024
University of Washington
2024
Carver Bible College
2008-2024
University of Minnesota
2024
University of Minnesota Medical Center
2016-2024
University of Iowa Health Care
2021
University of Iowa Hospitals and Clinics
2019
University of Iowa Holden Comprehensive Cancer Center
2019
Iowa Policy Project
2014
T cell memory depends on factors that regulate expansion and death of these cells after antigenic stimulation. Mice deficient in perforin interferon-γ (IFN-γ) exhibited increased expansion, altered immunodominance, decreased antigen-specific CD8 + infection with an attenuated strain Listeria monocytogenes , which was cleared from mice. Expansion controlled by perforin, whereas IFN-γ regulated immunodominance the phase. Thus, distinct elements homeostasis independently their role as...
Infection of mice with sporozoites Plasmodium berghei or yoelii has been used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria vaccines. Unfortunately, repeated success such vaccines in not translated readily effective humans. Thus, may be better as models dissect basic parameters required for immunity -infection than preclinical vaccine models. In turn, this information aid the rational design Here, we describe a model circumsporozoite-specific memory CD8...
Abstract Determining the magnitude and kinetics, together with phenotypic functional characteristics of responding CD8 T cells, is critical for understanding regulation adaptive immunity as well in evaluating vaccine candidates. Recent technical advances have allowed tracking some cells to infection, a body information now exists describing changes that occur known Ag-specificity during their activation, expansion, memory generation inbred mice. In this study, we demonstrate Ag but not...
Radiation-attenuated Plasmodium sporozoites (RAS) are the only vaccine shown to induce sterilizing protection against malaria in both humans and rodents. Importantly, these "whole-parasite" vaccines currently under evaluation human clinical trials. Studies with inbred mice reveal that RAS-induced CD8 T cells targeting liver-stage parasites critical for protection. However, paucity of defined cell epitopes has precluded precise understanding specific characteristics protective responses....
Abstract T cell factor-1 (TCF-1) and lymphoid enhancer-binding factor 1, the effector transcription factors of canonical Wnt pathway, are known to be critical for normal thymocyte development. However, it is largely unknown if has a role in regulating mature activation cell-mediated immune responses. In this study, we demonstrate that, like IL-7Rα CD62L, TCF-1 1 exhibit dynamic expression changes during responses, being highly expressed naive cells, downregulated upregulated again memory...
Highlights•Influenza-specific quaternary (4°M) lung Trm persist longer than 1°M Trm•Circulating 4°M CD8+ T cells have prolonged Tem phenotype compared to cells•Circulating exhibit sustained migration the and conversion Trm•Prolonged maintenance extends heterosubtypic immunity influenzaSummaryLung-resident primary memory cell populations (Trm) induced by a single influenza infection decline within months, rendering host susceptible new infections. Here, we demonstrate that, relative virus...
Microbial exposures can define an individual's basal immune state. Cohousing specific pathogen-free (SPF) mice with pet store mice, which harbor numerous infectious microbes, results in global changes to the system, including increased circulating phagocytes and elevated inflammatory cytokines. How these differences state influence acute response systemic infection is unclear. Cohoused exhibit enhanced protection from virulent Listeria monocytogenes (LM) infection, but morbidity mortality...
Non-canonical lipolysis induced by inflammatory cytokines or Toll-like receptor ligands is required for the regulation of inflammation during endotoxemia and sepsis. Canonical catecholamines declines aging due to factors including an expansion lymphocytes, pro-inflammatory macrophage polarization, increase in chronic low-grade inflammation; however, extent which non-canonical pathway active impacted immune cells remains unclear. Therefore, we aimed define from old mice influence We...