A5080407311- Immunotherapy and Immune Responses
- Advancements in Transdermal Drug Delivery
- Trypanosoma species research and implications
- Library Science and Information Literacy
- Malaria Research and Control
- Mosquito-borne diseases and control
- vaccines and immunoinformatics approaches
- Vaccine Coverage and Hesitancy
- Research on Leishmaniasis Studies
- MicroRNA in disease regulation
- HIV Research and Treatment
- Dermatology and Skin Diseases
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Herpesvirus Infections and Treatments
- T-cell and B-cell Immunology
- Radiopharmaceutical Chemistry and Applications
- Immune Response and Inflammation
- Toxin Mechanisms and Immunotoxins
- Sphingolipid Metabolism and Signaling
- Transgenic Plants and Applications
- Virus-based gene therapy research
- Immune cells in cancer
- Cervical Cancer and HPV Research
University College Cork
2015-2024
Vaxart (United States)
2024
National Institute for Bioprocessing Research and Training
2024
University of North Carolina at Charlotte
2019-2020
Atkins (United States)
2019
Wake Forest University
2015
Centers for Disease Control and Prevention
1995-2014
University of Brighton
2014
Division of Parasitic Diseases and Malaria
2000-2013
Jenner Institute
2008-2013
From June 1990 through July 1991, intracerebral infection with the larval stage of pork tapeworm Taenia solium was diagnosed in four unrelated persons an Orthodox Jewish community New York City. None patients had eaten pork, and only one traveled to a country which T. endemic. We investigated this outbreak, screened serum samples from family members household contacts for antibodies cysticercosis, examined stool specimens employees eggs taenia species.The recurrent seizures brain lesions...
Infection of mice with sporozoites Plasmodium berghei or yoelii has been used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria vaccines. Unfortunately, repeated success such vaccines in not translated readily effective humans. Thus, may be better as models dissect basic parameters required for immunity -infection than preclinical vaccine models. In turn, this information aid the rational design Here, we describe a model circumsporozoite-specific memory CD8...
A total of 22 Cryptosporidium isolates from human immunodeficiency virus-infected patients Kenya, Switzerland, and the United States were examined at three genetic loci: 18S ribosomal DNA, HSP-70, acetyl coenzyme synthetase genes. Four distinct genotypes identified: (i) parvum "human" genotype, (ii) C. "cattle" (iii) felis, (iv) meleagridis. This is first report meleagridis in a host. These results those others indicate that immunocompromised individuals are susceptible to wide range species...
TCR beta chain gene expression of individual T cell clones that share the same MHC class II restriction and similar fine specificity for encephalitogenic NH2 terminus autoantigen myelin basic protein (MBP) has been examined. V was examined by FACS analysis with mAbs specific 8 subfamily genes. 14 18 (78%) NH2-terminal MBP-specific express a member subfamily. Southern used to identify which member(s) is expressed these clones. Each four uses 8.2, though two different 8.2-J 2 combinations were...
Although Trypanosoma cruzi, the parasite that causes Chagas disease, can be transmitted via organ transplantation, liver and kidney transplantation from infected donors may feasible. We describe outcomes of 32 transplant recipients who received organs 14 T. cruzi seropositive in United States 2001 to 2011. Transmission was confirmed 9 6 donors, including 3 4 (75%) heart recipients, 2 10 (20%) 15 (13%) recipients. Recommended monitoring posttransplant consisted regular testing by PCR,...
We analyzed 92 Cryptosporidium parvum isolates from humans and animals by a polymerase chain reaction/restriction fragment length polymorphism method based on the thrombospondin-related anonymous protein 2 gene sequence. Used as molecular marker, this can differentiate between two genotypes of C. elucidate transmission infection to humans.
Trypanosoma cruzi infection (i.e., Chagas disease) is an unusual complication that can occur after solid-organ transplantation and result in severe illness or death. In 2006, there were 2 heart transplant recipients Los Angeles, California, reported to have acute trypanosomiasis during the same month. We conducted investigation determine source of these infections.We reviewed medical, organ procurement, donor transfusion records recipients. The interviewed regarding any kind natural exposure...
Background Vaccine delivery into the skin has received renewed interest due to ease of access immune system and microvasculature, however stratum corneum (SC), must be breached for successful vaccination. This been achieved by removing SC abrasion or scarification delivering vaccine intradermally (ID) with traditional needle-and-syringes long microneedle devices. Microneedle patch-based transdermal studies have predominantly focused on antibody induction inactivated subunit vaccines. Here,...
Alternate prime/boost vaccination regimens employing recombinant replication-deficient adenovirus or MVA, expressing Influenza A virus nucleoprotein and matrix protein 1, induced antigen-specific T cell responses in intradermally (ID) vaccinated mice; with the strongest resulting from Ad/MVA immunization. In BALB/C mice immunodominant response was shifted previously identified epitope to a novel when antigen derived A/Panama/2007/1999 rather than A/PR/8. immunization routes did not affect...