A5078910938- Immunotherapy and Immune Responses
- Advancements in Transdermal Drug Delivery
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Dermatology and Skin Diseases
- HER2/EGFR in Cancer Research
- T-cell and B-cell Immunology
- Advanced Biosensing Techniques and Applications
- Toxin Mechanisms and Immunotoxins
- Nanofabrication and Lithography Techniques
- Viral gastroenteritis research and epidemiology
- Higher Education Research Studies
- Social Media in Health Education
- EFL/ESL Teaching and Learning
- Psoriasis: Treatment and Pathogenesis
- Intramuscular injections and effects
- Health Literacy and Information Accessibility
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Renal and related cancers
- Cancer Immunotherapy and Biomarkers
- Malaria Research and Control
- Web and Library Services
The University of Queensland
2013-2021
Mater Research
2017-2021
Translational Research Institute
2017-2020
Monash University
2019
University of Oxford
2011-2015
Jenner Institute
2011-2015
Dendritic cells (DC) initiate the differentiation of CD4+ helper T into effector including Th1 and Th17 responses that play an important role in inflammation autoimmune disease pathogenesis. In mice, are regulated by different conventional (c) DC subsets, with cDC1 being main producers IL-12p70 inducers responses, whilst cDC2 produce IL-23 to promote responses. The human subsets memory cell activation is not known. This study investigated production promoting cytokine IL-12p70, cytokines,...
Background Vaccine delivery into the skin has received renewed interest due to ease of access immune system and microvasculature, however stratum corneum (SC), must be breached for successful vaccination. This been achieved by removing SC abrasion or scarification delivering vaccine intradermally (ID) with traditional needle-and-syringes long microneedle devices. Microneedle patch-based transdermal studies have predominantly focused on antibody induction inactivated subunit vaccines. Here,...
The disadvantages of needle-based immunisation motivate the development simple, low cost, needle-free alternatives. Vaccine delivery to cutaneous environments rich in specialised antigen-presenting cells using microprojection patches has practical and immunological advantages over conventional needle delivery. Additionally, stable coating vaccine onto microprojections removes logistical obstacles presented by strict requirement for cold-chain storage distribution liquid vaccine, or...
Background The conventional type 1 dendritic cell subset (cDC1) is indispensable for tumor immune responses and the efficacy of checkpoint inhibitor (ICI) therapies in animal models but little known about role human CD141 + DC cDC1 equivalent patients with melanoma. Methods We developed a flow cytometry assay to quantify characterize blood subsets healthy donors stage 3 4 metastatic To examine whether harnessing DCs could improve ICIs melanoma, we humanized mouse model by engrafting...
Abstract Polio eradication is progressing rapidly and the live attenuated Sabin strains in oral poliovirus vaccine (OPV) are being removed sequentially, starting with type 2 April 2016. For risk mitigation, countries introducing inactivated (IPV) into routine vaccination programs. After 2016, monovalent OPV will be available for outbreak control. Because current IPV not suitable house-to-house campaigns (the intramuscular injections require health professionals), we developed a high-density...
Mice reconstituted with human hematopoietic stem cells are valuable models to study aspects of the immune system in vivo. We describe a humanized mouse model (hu mice) which fully functional CD141+ and CD1c+ myeloid CD123+ plasmacytoid dendritic (DC) develop from cord blood CD34+ immunodeficient mice. DC equivalents murine CD8+ /CD103+ essential for induction tumor-inhibitory cytotoxic T lymphocyte responses, making them attractive targets exploit development new cancer immunotherapies. used...
Abstract Objectives Vaccines that prime Wilms' tumor 1 (WT1)‐specific CD8 + T cells are attractive cancer immunotherapies. However, immunogenicity and clinical response rates may be enhanced by delivering WT1 to CD141 dendritic (DCs). The C‐type lectin‐like receptor CLEC9A is expressed exclusively DCs regulates T‐cell responses. We developed a new vaccine comprising human anti‐CLEC9A antibody fused investigated its capacity target activate naïve memory WT1‐specific cells. Methods was...
Background Dendritic cells (DCs) are crucial for the efficacy of cancer vaccines, but current vaccines do not harness key cDC1 subtype required effective CD8 + T-cell-mediated tumor immune responses. Vaccine immunogenicity could be enhanced by specific delivery immunogenic antigens to CD141 DCs, human equivalent. DCs exclusively express C-type-lectin-like receptor CLEC9A, which is important regulation T cell This study developed a new vaccine that harnesses anti-CLEC9A antibody specifically...
Micro-device use for vaccination has grown in the past decade, with promise of ease-of-use, painless application, stable solid formulations and greater immune response generation. However, designs highly immunogenic devices (e.g. gene gun, Nanopatch or laser adjuvantation) require significant energy to enter skin (30-90 mJ). Within this study, we explore a way more effectively penetration vaccination. These modifications change projections from cylindrical/conical shapes density 20,000 per...
Engaging influential stakeholders in meaningful exchange is essential for pharmaceutical companies aiming to improve care. At a time where opportunities face-to-face engagement are limited, the ability interact, learn and generate actionable insights through digital channels such as Twitter, of considerable value.The aim this study was evaluate among global diabetes mellitus researchers.We identified every tweet (20,614,515) scientific publication (44,135) regarding from 1 August 2018 2020....
Background: Dendritic cells (DC) are a heterogeneous cell population, with specialist subtypes driving specific immune responses. In mice, the cDC1 subset (also referred to as Batf3-dependent DC, XCR1+ CD8+ DC in lymphoid tissues and CD103+ peripheral tissues) is essential for induction of tumour responses efficacy checkpoint inhibitor blockade adoptive T immunotherapies. Vaccines that can deliver antigens (Ag) directly DCs vivo more effective than cell-based therapies mouse models promising...
<h3>Background</h3> Dendritic cells (DC) are crucial for the efficacy of cancer vaccines, but current vaccines do not harness key cDC1 subtype required effective CD8+ T cell mediated tumor immune responses. Vaccine immunogenicity could be enhanced by specific delivery immunogenic antigens to CD141+ DC, human equivalent. DC exclusively express C-type-lectin-like receptor CLEC9A, which is important regulation This study developed a new vaccine that harnesses anti-CLEC9A antibody specifically...
Abstract Dendritic cells (DC) are a heterogeneous cell population, with specialist subtypes driving specific immune responses. In mice, the cDC1 subset (also referred to as Batf3-dependent DC, XCR1+ CD8+ DC in lymphoid tissues and CD103+ peripheral tissues) is essential for induction of tumor responses efficacy checkpoint inhibitor blockade adoptive T-cell immunotherapies. Vaccines that can deliver antigens (Ag) directly DCs vivo more effective than cell-based therapies mouse models...