Emerging micro-scale medical devices are showing promise, whether in delivering drugs or extracting diagnostic biomarkers from skin. In progressing these through animal models towards clinical products, understanding the mechanical properties and skin tissue structure with which they interact will be important. Here, measurement analytical modelling, we advanced knowledge of for commonly used laboratory animals humans (~30 g to ~150 kg). We hypothesised that skin's stiffness is a function...

Abstract Polio eradication is progressing rapidly and the live attenuated Sabin strains in oral poliovirus vaccine (OPV) are being removed sequentially, starting with type 2 April 2016. For risk mitigation, countries introducing inactivated (IPV) into routine vaccination programs. After 2016, monovalent OPV will be available for outbreak control. Because current IPV not suitable house-to-house campaigns (the intramuscular injections require health professionals), we developed a high-density...

Abstract Microscale medical devices are being developed for targeted skin delivery of vaccines and the extraction biomarkers, with potential to revolutionise healthcare in both developing countries. The effective clinical development these is dependent on understanding macro-molecular diffusion properties skin. We hypothesised that varied according specific layers. Using three different molecular weights rhodamine dextran (RD) (MW 70, 500 2000 kDa) relevant vaccine therapeutic scales, we...

To secure a polio-free world, the live attenuated oral poliovirus vaccine (OPV) will eventually need to be replaced with inactivated vaccines (IPV). However, current IPV delivery is less suitable for campaign use than OPV, and more expensive. We are progressing microarray patch platform, Nanopatch, as an easy-to-use device administer vaccines, including IPV. The Nanopatch contains ultra-high density array (10,000/cm2) of short (~230 μm) microprojections that delivers dry coated into skin....

Micro-device use for vaccination has grown in the past decade, with promise of ease-of-use, painless application, stable solid formulations and greater immune response generation. However, designs highly immunogenic devices (e.g. gene gun, Nanopatch or laser adjuvantation) require significant energy to enter skin (30-90 mJ). Within this study, we explore a way more effectively penetration vaccination. These modifications change projections from cylindrical/conical shapes density 20,000 per...

With the development of wearable technologies, interfacial properties skin and devices have become much more important. For research purposes, porcine is often used to evaluate device performance, but differences between in vivo, situ ex vivo mechanical can potentially misdirect investigators during their technology. In this study, we investigated significant changes with without perfusion (in versus vitro tissue). The focus for study was a skin-targeting Nanopatch vaccine microneedle...

The success of total hip arthroplasty depends on the experience surgeon, and one ways surgeon currently determines final implant insertion depth is to listen change in audible pitch hammering sound. We investigated use vibration emissions as a novel method for quality assessment. A non-invasive contact microphone-based measurement system estimation, fixation fracture detection was developed using simplified vitro bone/implant (n = 5). 2583 audio recordings were analyzed obtain energy...

Background: In hip arthroplasties, surgeons rely on their experience to assess the stability and balance of tissues when fitting implant patients. During operation, use a modular, temporary set implants feel tension in surrounding soft adjust configuration. This process is naturally subjective therefore depends operator. Inexperienced undertaking arthroplasties are twice as likely errors than experienced colleagues, leading dislocations, pain discomfort for Methods: To address this issue,...

Packaging density, electrical performance and cost are the primary factors driving electronic package architectures for high-performance server markets. Considerations such as thermal mechanical reliability equally important but tend to be addressed later in design cycle. Presented this paper is a historical view of packaging trends leading current multi-die options. Particular attention must placed on limitations benefits offered by each design. Since packages have many junctions interest,...

Abstract We introduce a method for investigating sound change using audio proxies and interpolation between them. Using this leads us to consider the possible trajectories of attested changes in acoustic space allows run speech perception experiments with interpolated sounds examine patterning perceptual judgements. discuss implications understanding rate magnitude present approach as one which might fruitfully be applied wide range studies.

Abstract We introduce a method for investigating sound change using audio proxies and interpolation between them. Using this leads us to consider the possible trajectories of attested changes in acoustic space allows run speech perception experiments with interpolated sounds examine patterning perceptual judgements. discuss implications understanding rate magnitude present approach as one which might fruitfully be applied wide range studies.

With the development of wearable technologies, interfacial properties skin and devices have become much more important. For research purposes, porcine is often used, but differences between in vivo, situ ex vivo mechanical can potentially misdirect investigators for their technology development. In this study, we investigated significant changes to with without perfusion (in versus vitro tissue). The device focus study was a skin-targeting Nanopatch vaccine microneedle device, employed...

Objective: To explore the effect of a delayed pedicle gastrocnemius muscle flap transposition for treatment knee joint deep infection secondary to wound necrosis after total arthroplasty (TKA). Methods: The clinical data 7 patients treated in Shanxi Provincial People's Hospital with from December 2015 September 2019 necrosis, exposed prosthesis and TKA were analyzed retrospectively. Before transplantation, 5 had received at least one debridement but failed relapse, resulted an prostheses...

The success of total hip arthroplasty depends on the experience surgeon, and one ways surgeon currently determines final implant insertion depth is to listen change in audible pitch hammering sound. We investigated use acoustic vibration emissions as a novel method for quality assessment. A non-invasive contact microphone-based measurement system estimation, fixation fracture detection was developed using simplified vitro bone/implant (n=5). 2583 audio recordings were analysed obtain energy...

conducted interviews with twenty-two Eugene veterans and military family members, from these cre ated the script for Telling.The play was performed by eleven of

<p>Inexperienced surgeons undertaking hip arthroplasties are twice as likely to experience errors than their experienced colleagues, leading dislocations, pain and discomfort for the patients. To address this issue, a new 3DOF force measurement system was developed integrated in multiple prototypes able measure forces movements intraoperatively 3D. The were evaluated three cadaver trials, with goal of providing objective data help determine optimal implant fit configuration. devices...

With the development of wearable technologies, interfacial properties skin and devices have become much more important. For research purposes, porcine is often used, but differences between in vivo, situ ex vivo mechanical can potentially misdirect investigators for their technology development. In this study we investigated significant changes to with without perfusion (in versus vitro tissue). The device focus was a skin-targeting Nanopatch vaccine microneedle device, employed assess...