A5040071446- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- IL-33, ST2, and ILC Pathways
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Immune Response and Inflammation
- Reproductive System and Pregnancy
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Diabetes and associated disorders
- Hepatitis C virus research
- T-cell and Retrovirus Studies
- Cytomegalovirus and herpesvirus research
- Hydraulic and Pneumatic Systems
- Medicinal Plants and Bioactive Compounds
- Pomegranate: compositions and health benefits
- Autoimmune and Inflammatory Disorders Research
- Virus-based gene therapy research
- Chronic Myeloid Leukemia Treatments
- interferon and immune responses
- Immune cells in cancer
University of Lausanne
2015-2024
University Hospital of Lausanne
2019
Ludwig Cancer Research
2009-2018
École Polytechnique Fédérale de Lausanne
2016
Ludwig Cancer Research
1998-2009
University of Massachusetts Chan Medical School
2002-2007
University of Toronto
2007
Memorial Sloan Kettering Cancer Center
2007
Keio University Hospital
2007
Institute of Cancer Research
2005
Immune protection from intracellular pathogens depends on the generation of terminally differentiated effector and multipotent memory precursor CD8 T cells, which rapidly regenerate cells during recurrent infection. The identification factors pathways involved in cell differentiation is obvious importance to improve vaccination strategies. Here, we show that mice lacking factor 1 (Tcf-1), a nuclear canonical Wingless/Integration (Wnt) signaling pathway, mount normal responses infection with...
Abstract Differentiation and fate of virus-specific CD8 + T cells after cessation chronic antigen stimulation is unclear. Here we show that a TCF1 CD127 PD1 hepatitis C virus (HCV)-specific T-cell subset exists in chronically infected patients with phenotypic features exhaustion memory, both before treatment direct acting antiviral (DAA) agents. This maintained during, for long duration after, HCV elimination. After re-challenge the less differentiated population expands, which accompanied...
During T cell development in the thymus, receptor (TCR) alpha, beta, gamma, and delta genes are rearranged expressed. TCR rearrangement strictly depends upon coordinate activity of two recombinase activating genes, Rag-1 Rag-2. In this study we have followed expression these at different stages intrathymic development. The results indicate that there periods high Rag-2 mRNA expression. first wave peaks early CD25+CD4-CD8-CD3- stage coincides with initial appearance transcripts derived from...
alphabeta and gammadelta T cells originate from a common, multipotential precursor population in the thymus, but molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as gammadelta-specific gene immune system. Using transgenic mice, we showed that transcription factor promotes cell development while opposing differentiation. Conversely, mice deficient expression exhibited impaired of not cells. One mechanism SOX13 function is inhibition signaling by...
Abstract T cell factor-1 (TCF-1) and lymphoid enhancer-binding factor 1, the effector transcription factors of canonical Wnt pathway, are known to be critical for normal thymocyte development. However, it is largely unknown if has a role in regulating mature activation cell-mediated immune responses. In this study, we demonstrate that, like IL-7Rα CD62L, TCF-1 1 exhibit dynamic expression changes during responses, being highly expressed naive cells, downregulated upregulated again memory...
The formation of central CD8 T cell memory in response to infection depends on the transcription factor Tcf1 (Tcf7). is expressed at high levels naive cells but downregulated most during effector differentiation. relevance downregulation for differentiation and signals controlling expression have not been elucidated. Here, we show that systemic inflammatory dendritic vaccination bacterial infections. suppressive effect was mediated by cytokine interleukin 12 (IL-12), which acted via STAT4...