A5062946138- Multicomponent Synthesis of Heterocycles
- Catalytic C–H Functionalization Methods
- Synthesis and biological activity
- Synthesis of Organic Compounds
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Synthesis and Biological Evaluation
- Fluorine in Organic Chemistry
- Synthesis and Characterization of Pyrroles
- Chemical Synthesis and Reactions
- Synthesis of heterocyclic compounds
- Oxidative Organic Chemistry Reactions
- Synthesis and Reactions of Organic Compounds
- Synthesis and Catalytic Reactions
- Cyclopropane Reaction Mechanisms
- Pelvic and Acetabular Injuries
- Spinal Fractures and Fixation Techniques
- Asymmetric Synthesis and Catalysis
- Catalytic Cross-Coupling Reactions
- Knee injuries and reconstruction techniques
- Foot and Ankle Surgery
- Catalytic Alkyne Reactions
- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- Synthesis of Indole Derivatives
Zhejiang University of Technology
2016-2025
University of South China
2003-2025
Nanjing Tech University
2025
Hainan University
2024
Ningbo University
2024
Research Center for Applied Science, Academia Sinica
2024
National Yang Ming Chiao Tung University
2024
Dongfeng Motor Group (China)
2021-2023
Sichuan University
2022
Pharmaceutical Biotechnology (Czechia)
2021
Twenty-seven novel (E)-3-[2-arylideneaminoethyl]-2-[4-(trifluoromethoxy)anilino]-4(3H)-quinazolinone derivatives were synthesized by reacting various aromatic aldehydes with intermediate 6. The target compounds characterized (1)H NMR, (3)C IR, and elemental analysis. Bioassay results revealed that some of the have strong antifungal activities against six fungi ( Gibberella zeae , Fusarium oxysporum Clematis mandshurica Paralepetopsis sasakii Phytophthora infestans Sclerotinia sclerotiorum )...
An efficient multicomponent reaction for the preparation of vinyl sulfone was achieved by hydrogenation/bifunctional sulfonylation alkynyl esters with N- allyl bromodifluoroacetamide, DABSO, and H 2 O under visible-light-only conditions.
CuCoFe(CN) 6 prepared by coprecipitating and ion-exchanging exhibits high initial discharge capacity, long term cycling life, excellent rate performance in aqueous copper ion batteries.
We described here the first example of cobalt-electro-catalyzed enantioselective C–H acyloxylation arylphosphinamides with carboxylic acids to generate P-stereogenic scaffolds.
Abstract An efficient synthesis of novel coumarin derivatives via a three‐component condensation 4‐hydroxycoumarin, aldehydes and aromatic amines catalyzed by sulfonic acid functionalized ionic liquid L ‐2‐(hydroxymethyl)‐1‐(4‐sulfobutyl)pyrrolidinium hydrogen sulfate ([HYSBPI]·HSO 4 ) is reported. The condensed product was obtained with excellent yields in water under microwave irradiation condition. antitumor activities all the synthesized compounds were assessed on two different human...
The objective of this study is to explore clinical risk factors for venous thromboembolism (VTE) in postoperative lung cancer patients order provide a basis the prevention and treatment VTE.A total 1,001 were retrospectively analyzed. Each patient was confirmed with surgical pathology diagnosis had complete follow-up record. VTE identified combination spiral computed tomography (CT), pulmonary angiography, color Doppler ultrasound. We used life table method create an occurrence frequency...
The Vilsmeier (or Vilsmeier-Haack) reaction has historically been a topic of great interest to organic chemists, and it continues attract considerable attention. Since its discovery in 1927, 1 i...
The copper-catalyzed versatile C(sp2)–C(sp3) bond formation with N-heteroaromatics and hydrogen donors was developed. Various alkanes ethers reacted quinolines, isoquinolins, pyridines, benzooxazole benzothiazole to give the corresponding C(sp2)–H alkylation products via cross-dehydrogenative coupling. On other hand, we achieved high regioselective C(sp2)–halogen of (hetero)aryl chlorides bromides elimination halogen radical. reaction mechanism investigated control experiments.
Rh(<sc>iii</sc>)-catalyzed coupling of phenylhydrazines with 1-alkynylcyclobutanols was realized through a hydrazine-directed C–H functionalization and [4+1] annulation pathway.
An intriguing conversion of arylglyoxal, cyclic dicarbonyl compounds and phenols to diverse furan analogues under FeCl3 or MeSO3H catalysis is reported. Utilizing this synthetic protocol, a variety could be easily obtained in moderate good yields with different substituted patterns by varying the reaction medium. Atom-economical characteristics mild conditions method are accord concept modern green chemistry.
For the first time, a photoredox-catalyzed alkoxycarbonylation/tricyclization reaction was developed by employing readily accessible enediynes and alkyloxalyl chlorides as starting materials, enabling synthesis of ester-substituted polycyclic N-heteroaromatics under mild conditions through radical-mediated mechanism. This photocatalytic strategy is notable for its exceptional compatibility with diverse functional groups, scalability, efficiency in formation rings chemical bonds. Notably,...
A facile Fe(III)-catalyzed oxidative decarboxylative radical coupling reaction of α,α-difluoroarylacetic acids with coumarins has been developed. This transformation, which provides a series C-3 difluoroarylmethylated containing various functional groups in moderate-to-good yields, features easily accessible starting materials and operational simplicity.
The first method for constructing pyrido[3,2- c ]coumarin derivatives via a radical cascade cyclization process was proposed, which can introduce active fragments.
A novel approach for constructing 3,4-difunctionalized benzo[ h ]coumarins through a metal-free multicomponent reactions with mild reaction conditions.
Background: Posterior cruciate ligament (PCL) injury is a relatively common musculoskeletal condition. However, there currently lack of consensus on decision-making, treatment and postoperative management for such injuries. Objectives: To use the modified Delphi method to reach expert PCL injury. Methods: A literature search PubMed, Cochrane Library, Embase, Web Science articles up 17 October 2024, support development recommendation statements. An Expert Panel 90 experienced clinicians from...
A methanesulfonic acid promoted three-component reaction has been developed for the synthesis of functionalized pyrido[2,3-<i>c</i>]coumarin derivatives from ketones, aromatic aldehydes, and 3-aminocoumarin. In this simple efficient protocol, products were obtained in moderate to good yields (28 examples). The proceeds by an asynchronous [4+2] cycloaddition (inverse-electron-demand Diels–Alder reaction).
A facile silver-catalyzed dual decarboxylation of arylthio-difluoroacetic acid with coumarin-3-carboxylic acids/chromone-3-carboxylic acids was developed.
Herein, an electrochemical trifluoromethylation/cyclization reaction of unactivated alkenes within benzimidazole molecules by direct cascade with C2–H has been developed.
Trimethylamine dehydrogenase (TMADH) is an iron−sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. It contains a unique flavin, in 6-S-cysteinyl FMN, which bent by ∼25° along N5−N10 axis flavin isoalloxazine ring. This unusual conformation thought modulate properties facilitate catalysis, has been postulated be result covalent linkage Cys-30 at C6 atom. We report here crystal structures recombinant wild-type C30A mutant...
An efficient method for the synthesis of furo[3,2‐c]coumarins through FeCl 3 or ZnCl 2 ‐mediated multicomponent tandem reactions in presence arylglyoxal monohydrates, 4‐hydroxycoumarin, and allyltrimethylsilane toluene is reported. This reaction involves formation two C‐C bonds one C‐O bond. process provided privileged structures moderate to good yields under mild conditions. Notable features procedure such as easily accessible starting materials, functional group tolerance, high atom...