A5037807926- Shoulder Injury and Treatment
- Knee injuries and reconstruction techniques
- Shoulder and Clavicle Injuries
- Total Knee Arthroplasty Outcomes
- Sports injuries and prevention
- Tendon Structure and Treatment
- Nerve Injury and Rehabilitation
- Extracellular vesicles in disease
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Orthopedic Surgery and Rehabilitation
- Muscle Physiology and Disorders
- Lower Extremity Biomechanics and Pathologies
- Cardiac Valve Diseases and Treatments
- Nutrition and Health in Aging
- Osteoarthritis Treatment and Mechanisms
- Photonic and Optical Devices
- Bone fractures and treatments
- Adhesion, Friction, and Surface Interactions
- Cardiovascular Syncope and Autonomic Disorders
- Bone Tissue Engineering Materials
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Spine and Intervertebral Disc Pathology
Shanghai Jiao Tong University
2021-2025
Shanghai First People's Hospital
2021-2025
Fujian Provincial People's Hospital
2024
Huashan Hospital
2012-2022
Fudan University
2012-2022
First Affiliated Hospital of Xi'an Jiaotong University
2022
Huanggang Normal University
2022
State Council of the People's Republic of China
2016
Union Hospital
2016
Huazhong University of Science and Technology
2016
The critical shoulder angle (CSA) is the created between superior and inferior bone margins of glenoid most lateral border acromion. A few studies recently investigated relation CSA functional outcomes after rotator cuff repair. However, there a lack research investigating effect on postoperative tendon integrity repair.To assess effects repair.Cohort study; Level evidence, 3.All patients who underwent repair for full-thickness supraspinatus tears by 1 senior surgeon January 2010 2014 were...
Fibrosis is common after skeletal muscle injury, undermining tissue regeneration and function. The mechanism underlying fibrosis remains unveiled. Transforming growth factor-β/Smad signaling pathway supposed to play a pivotal role. However, how microRNAs interact with transforming factor-β/Smad-related unclear. We showed that microRNA (miR)-24-3p miR-122-5p declined in fibrosis, which was consequence of factor-β. Upregulating Smad4 suppressed two microRNAs, whereas inhibiting elevated...
Background: The optimal graft choice of anterior cruciate ligament (ACL) reconstruction remains controversial. Purpose: To compare the outcomes, especially long-term cumulative failure rate, ACL using either synthetics with remnant preservation or hamstring autografts (4-strand semitendinosus and gracilis tendons). Study Design: Cohort study; Level evidence, 2. Methods: A total 133 patients who underwent (synthetics: n = 43; autografts: 90) between July 2004 December 2007 were included....
Corticosteroid injection is a common treatment for frozen shoulder, but controversy still exists regarding the site with best outcome.To treat shoulder in freezing stage corticosteroid injection, single into rotator interval (RI) could yield better effects terms of improvement pain, passive range motion (ROM), and function than would an intra-articular (IA) or subacromial (SA) space.Randomized controlled trial; Level evidence, 1.Patients primary were randomized 3 groups: RI IA SA...
Evidence accumulated that mesenchymal stem cell (MSC) therapy ameliorated osteoarthritis (OA) via paracrine effect, whereas conditioned medium (CM) of MSCs contains all the secretomes. In vitro studies have proved its therapeutic effect in OA, but few vivo evidences were unveiled. This study investigated MSCs-CM an animal model OA. OA was induced by anterior cruciate ligament transaction and destabilization medial meniscus 12 rats bilaterally. The CM group (N = 6) administered with...
Background: The hamstring tendons are commonly harvested for anterior cruciate ligament (ACL) reconstruction with detachment of the tibial insertion. Retaining insertion may help to preserve vascularity and viability graft bypass stages avascular necrosis revascularization, which might be beneficial maturity. Purpose: To investigate compare maturity by magnetic resonance imaging (MRI) after ACL preservation or tendon at up 2 years. Study Design: Randomized controlled trial; Level evidence,...
Background: Stem cell–conditioned medium (CM) has been increasingly used in regenerative medicine. However, its effect on graft-host integration after anterior cruciate ligament (ACL) reconstruction (ACLR) remains unclear. Purpose: To examine the of human bone marrow stem cell (hBMSC)–CM graft-bone and graft midsubstance ligamentization a rat model ACLR. Study Design: Controlled laboratory study. Methods: CM was obtained from supernatant commercially available hBMSCs serum-free Dulbecco’s...
Skeletal muscle contusion is among the most common injuries in traumatology and clinics of sports medicine. The injured vulnerable to re-injury owing fibrosis formation. Given that bone marrow stromal cell-derived exosomes (BMSC-Exos) displayed promising therapeutic effect for various tissues, we used BMSC-Exos treat skeletal investigated its effects on healing. In this study, vivo model was established by subjecting tibialis anterior young male mice hit injury, vitro inflammation...
Adhesive capsulitis is a common shoulder disorder inducing joint capsule fibrosis and pain. When combined with rotator cuff tear (RCT), treatments can be more complex. Currently, targeted therapy lacking. Since adhesive reported to related circulating materials, we analyzed the contents biology of exosomes from RCT patients without capsulitis, in an attempt developing targeting treatment. Samples consecutive cohort for surgery were collected. Circulating exosomal miRNAs sequencing used...
Exercise is crucial for preventing Alzheimer's disease (AD), although the exact underlying mechanism remains unclear. The construction of an accurate AD risk prediction model beneficial as it can provide a theoretical basis preventive exercise prescription. In recent years, necroptosis has been confirmed important manifestation AD, and known to inhibit neuronal cells. this study, we extracted 67 necroptosis-related genes 32 lncRNAs screened key predictive through random forest analysis....
The response of plants to drought has received significant attention, but far less attention been given the dynamic during recovery from drought. Photosynthetic performance and hydraulic capacity were monitored in seedlings Hevea brasiliensis under water stress following rewatering. Leaf relation, gas exchange rate conductivity decreased gradually after fell below a threshold, whereas instantaneous use efficiency osmolytes increased significantly. After 5 days rewatering, leaf maximum...
Growing evidence suggests the importance of microRNAs (miRNAs) in stress signaling pathways. Transforming growth factor-β (TGF-β) is a potent cytokine that promotes development skeletal muscle fibrosis after acute contusion. However, how miRNAs are involved TGF-β and confer robustness TGF-β-induced fibrotic response remains to be fully elucidated. Here, we demonstrated miR-146a-5p (miR-146) levels were reduced mouse model It was also found treatment decreased expression miR-146 vitro dose-...
Massive rotator cuff tears (MRCTs) are difficult to repair because of the retraction and poor mobility torn tendons. In current study, co-electrospun dual nano-scaffolds poly(lactic-co-glycolic acid)/collagen I-polycaprolactone/nanohydroxyapatite (PLGA/Col-PCL/nHA) were fabricated used bridge MRCTs infraspinatus tendons in a rabbit model. PLGA-PCL served as control. The PLGA or PLGA/Col sides scaffolds connected tendon stumps. PCL PCL/nHA side was inserted into bone tunnel at insertion...