A5100603221- Extracellular vesicles in disease
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Reproductive System and Pregnancy
- Renal and related cancers
- Peptidase Inhibition and Analysis
- Electrospun Nanofibers in Biomedical Applications
- Diabetic Foot Ulcer Assessment and Management
- Circular RNAs in diseases
- Prenatal Screening and Diagnostics
- MicroRNA in disease regulation
- Endometriosis Research and Treatment
- Vector-borne infectious diseases
- Pluripotent Stem Cells Research
- Bat Biology and Ecology Studies
- Wound Healing and Treatments
- Human-Animal Interaction Studies
- Advancements in Battery Materials
- Histiocytic Disorders and Treatments
- Silk-based biomaterials and applications
- Nuclear Receptors and Signaling
- Cardiovascular Disease and Adiposity
- Intracerebral and Subarachnoid Hemorrhage Research
- Inflammasome and immune disorders
- Infant Nutrition and Health
- Machine Learning in Healthcare
Southern Medical University
2021-2025
Nanfang Hospital
2021-2025
Peking Union Medical College Hospital
2019-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Duke-NUS Medical School
2024
Soochow University
2021-2024
Soochow University
2024
Hubei University of Medicine
2021-2024
Chongqing Medical University
2024
Jiujiang University
2023
Endothelial cells (ECs) and macrophages engage in tight specific interactions that play critical roles cardiovascular homeostasis the pathogenesis of atherosclerosis. Extracellular vesicles (EVs) are circular membrane fragments released from endosomal compartment as exosomes or shed surfaces membranes most cell types. Increasing evidence indicates EVs a pivotal role cell-to-cell communication. However, contribution EVs, determine by oxidized low-density lipoprotein (ox-LDL)-exposed and/or...
Lung carcinoma is the most common type of cancer and leading cause cancer-related death worldwide. Among numerous therapeutic strategies for treatment lung cancer, adeno-associated virus (AAV)-mediated gene transfer has been demonstrated to have potential effectively suppress tumor growth or reverse progression disease in a number preclinical studies. AAV vector safety profile; however, relatively low delivery efficacy particular subtypes limited its prospective clinical translation....
Drug-resistant bacterial infections and biofilm formation play important roles in the pathogenesis of diabetic refractory wounds. Tea tree oil (TTO) exhibits antimicrobial, antimycotic, antiviral activities, especially against common clinically resistant strains, such as methicillin-resistant Staphylococcus aureus (MRSA), making it a potential natural antimicrobial for treatment acute chronic However, TTO is insoluble water, volatile, light-sensitive, cytotoxic. While previous macroscopic...
Adeno-associated virus (AAV)-mediated gene transfer has demonstrated potential in effectively promoting re-epithelialization and angiogenesis. AAV vector a safety profile; however, the relatively low delivery efficacy chronic wound with an inflammatory microenvironment external exposure limited its prospective clinical translation. Here, we generated AAV-containing EVs (EV-AAVs) from cultured HEK 293T cells confirmed that efficiency of VEGF-EV-AAV significantly surpassed free AAV....
Abstract Background Hereditary transthyretin amyloid cardiomyopathy (ATTR-CM) is an increasingly recognized progressive with heterogenous clinical manifestations that lead to its misdiagnosis and poor prognosis. This study was performed describe the characteristics natural history of Chinese patients improve awareness this condition. Methods In study, we retrospectively investigated 23 a confirmed diagnosis hereditary ATTR-CM in Peking Union Medical College hospital from From January 1, 2000...
Abstract Background Miscarriage is a frustrating complication of pregnancy that common among women reproductive age. Insufficient decidualization which not only impairs embryo implantation but disturbs fetomaternal immune-tolerance, has been widely regarded as major cause miscarriage; however, the underlying mechanisms resulting in decidual impairment are largely unknown. Methods With informed consent, tissue from patients with spontaneous abortion or normal pregnant was collected to detect...
The tissue-engineered epidermal (TEE), composed of biocompatible vectors and autogenous functional cells, is a novel strategy to solve the problem shortage donor skin sources. human primary keratinocyte (HPK), major components, are self-evident vital in wound healing was considered as one preferred seed cells for TEEs. Since process separating HPKs from triggers stress state achieving its rapid adhesion proliferation on biomaterials remains challenging. key clinical application ensure normal...
The significant morphological differences and abundant germplasm resources of Chinese indigenous dog breeds can be attributed to the diverse geographical environment, including plateaus, mountains, a long history raising dogs. combination both natural artificial selection during past several thousand years has led hundreds with distinct traits environmental adaptations. China is one earliest countries domesticate dogs there are more than 50 ancient breeds. In this study, run homozygosity...
To determine the relationship between psychological resilience, nursing practice environment, and moral courage of clinical nurses also factors influencing courage.
Amyloid transthyretin (ATTR) amyloidosis caused by misfolded into amyloid deposits in nerve and heart is a progressive rare disease. The unknown pathogenesis the lack of therapy make 5-year survival prognosis extremely poor. Currently available ATTR drugs can only relieve symptoms slow down progression, but no drug has demonstrated curable effect for this growing volume pharmacological data large-scale genome transcriptome bring new opportunities to find potential through computational...
Hereditary transthyretin amyloid cardiomyopathy is cardiac involvement in systemic amyloidosis. For the first time, we generated induced pluripotent stem cell (iPSC) line of hATTR-CM carrying TTR mutation p.Asp38Asn. We isolated peripheral blood mononuclear cells from patient's blood. The reprogramming PBMCs achieved a state by transfection non-integrated episomal vectors. demonstrated pluripotency with presence surface markers, expression pluripotency-related genes and ability to form...
Hereditary transthyretin amyloidosis (ATTRv) is a rare, fatal, autosomal dominant disease with more than 140 mutations discovered. Three phenotypes of amyloid infiltration are neuropathy (ATTRv-PN), cardiopathy (ATTRv-CM), and + (ATTRv-MIX). The lack ATTR-specific biomarkers, difficulties in biopsy evidence, limited known pathogenic mechanisms have made diagnosis difficult. Newly emerging noninvasive measures for monitoring progression disease-modifying therapies improved early patient...
To the Editor: The global burden of premature coronary artery disease (CAD) is increasing among young population. Premature CAD generally refers to occurrence obstructive atherothrombotic lesions in men and women aged <55 years <65 years, respectively, particularly those <45 years.[1] incidence younger population has remained stable or increased, despite declining older adults. Patients with have a poor long-term prognosis, experiencing high rate recurrent ischemic events, rapid progression...
Abstract Background Miscarriage is a frustrating complication of pregnancy that common in women reproductive age. Insufficient decidualization which not only impairs embryo implantation but disturbs the fetomaternal immune-tolerance, has been widely regarded as major cause miscarriage; however, underlying mechanisms resulting decidual impairment are largely unknown. Methods With informed consent, tissue from patients with spontaneous abortion or normal pregnant were collected to detect...