A5064990559- Pediatric Hepatobiliary Diseases and Treatments
- Infant Nutrition and Health
- Intestinal Malrotation and Obstruction Disorders
- Evacuation and Crowd Dynamics
- Ferroptosis and cancer prognosis
- Tracheal and airway disorders
- Autonomous Vehicle Technology and Safety
- Congenital Anomalies and Fetal Surgery
- Traffic control and management
- Simulation and Modeling Applications
- Esophageal and GI Pathology
- Traffic and Road Safety
- Music Therapy and Health
- Transportation Planning and Optimization
- Congenital Diaphragmatic Hernia Studies
- Advanced Steganography and Watermarking Techniques
- Neuroendocrine Tumor Research Advances
- Dysphagia Assessment and Management
- Immune Cell Function and Interaction
- COVID-19 diagnosis using AI
- Multiple Myeloma Research and Treatments
- International Student and Expatriate Challenges
- Nerve injury and regeneration
- Protein Degradation and Inhibitors
- Communication in Education and Healthcare
Southern Medical University
2025
Sun Yat-sen University
2012-2025
Hunan Children's Hospital
2013-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2012-2024
Central South University
2024
Wuhan University of Science and Technology
2015-2019
Wuhan University of Technology
2015-2016
Dongguan People’s Hospital
2006-2011
Wuhan Municipal Engineering Design & Research Institute
2011
Chongqing Municipal Health Commission
2005
In the past few years, immune checkpoint blockade (ICB) therapy has emerged as a breakthrough treatment for cancers and demonstrated inspiring effects in tumor patients with Epstein-Barr virus (EBV) infection. To allow more to benefit from immunotherapy, exploring novel biomarkers based on EBV-related tumors immunotherapy cohorts was pursued present study. The essential that may enhance antitumor immunity across were identified using large-scale transcriptomic profiles of EBV-associated...
<title>Abstract</title> <bold>Purpose</bold> The study aims to assess the clinical efficacy and safety profile of plerixafor in combination with polyethylene glycolated recombinant human granulocyte colony-stimulating factor (PEGylated rhG-CSF) for autologous hematopoietic stem cell (auto-HSC) mobilization Chinese patients diagnosed multiple myeloma (MM). <bold>Methods</bold> A retrospective analysis was conducted evaluate collection efficiency, post-transplant reconstitution,...
Adeno-associated virus (AAV)-mediated gene transfer has demonstrated potential in effectively promoting re-epithelialization and angiogenesis. AAV vector a safety profile; however, the relatively low delivery efficacy chronic wound with an inflammatory microenvironment external exposure limited its prospective clinical translation. Here, we generated AAV-containing EVs (EV-AAVs) from cultured HEK 293T cells confirmed that efficiency of VEGF-EV-AAV significantly surpassed free AAV....
<title>Abstract</title> <bold>Purpose </bold>The study aims to assess the clinical efficacy and safety profile of plerixafor in combination with polyethylene glycolated recombinant human granulocyte colony-stimulating factor (PEGylated rhG-CSF) for autologous hematopoietic stem cell (auto-HSC) mobilization patients diagnosed multiple myeloma (MM). <bold>Methods</bold> A retrospective analysis was conducted evaluate collection efficiency, post-transplant reconstitution, mobilization-related...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumors, characterized by diagnosis at an advanced stage and a poor prognosis. As member S100 protein family, S100A10 regulates multiple biological functions related to cancer progression metastasis. However, role in PDAC still not completely elucidated. In this study, we reported that was significantly up-regulated tissue associated with prognosis integrated bioinformatic analysis human samples. vitro, down-regulation...
Pedestrian-cyclist interaction is closely relative with traffic safety on campus intersection. The relationships of flow, speed, Level Service (LOS) pedestrian-cyclist conflict and interference were studied. Studying was using collected video data which recorded the behaviours pedestrians cyclists at a non-signalized intersection campus. cyclists' flows by statistic software, videos decoded into image frames, their trajectory distance acquired processing converted numbers as VCNXY(Video...
Accurate prediction of the risk progression coronavirus disease (COVID-19) is needed at time hospitalization. Logistic regression analyses are used to interrogate clinical and laboratory co-variates from every hospital admission an area 2 million people with sporadic cases. From a total 98 subjects, 3 were severe COVID-19 on admission. remaining 24 developed severe/critical symptoms. The predictive model includes four co-variates: age (>60 years; odds ratio [OR] = 12 [2.3, 62]); blood oxygen...
Background. Necrotizing enterocolitis (NEC) is a devastating disease affecting the gastrointestinal tract in newborn period. In recent years, role of apoptosis and autophagy intestinal mucosal barrier dysfunction has come into prominence research regarding pathogenesis NEC. β-Carotene well-known vitamin A precursor, its content breast milk relatively high, especially colostrum. present study, we investigated protective effect β-carotene on necrotizing model cells IEC-6 induced by...
This study aimed to define the effectiveness of thoracoscopic versus open repair gross type C oesophageal atresia (EA) based on experience a single centre over decade.This retrospective cohort included patients who were admitted Hunan Children's Hospital between January, 2010 and December, 2021 underwent surgery for EA.A total 359 EA during period, which 142 completed via an approach 217 attempted (seven converted surgery). There no differences in demographics or comorbidities thoracoscopy...
Biliary atresia (BA) is a devastating congenital disease characterized by inflammation and progressive liver fibrosis. Activation of hepatic stellate cells (HSCs) plays central role in the pathogenesis Our study aimed to investigate pharmacological effect potential mechanism pirfenidone (PFD) andrographolide (AGP) separately together on fibrosis BA.
Pedestrian small group is an important part of crowds in public places, they maintain similar speed and direction to reach the destination together through interactive cooperation. However, research into influence groups on pedestrian flow dynamics has been limited. Previous behaviors mainly focus size walking spatial pattern problem from a static point view. The dynamic spatial-temporal trajectory features among people can provide significant insight dynamics. This paper's aim quantitative...
With the rapid development of transportation, traffic questions have become major issue for social, economic and environmental aspects. Especially, during serious emergencies, it is very important to alleviate road congestion improve efficiency evacuation reduce casualties, addressing these problems has been a task agencies responsible in recent decades. Advanced guidance strategies developed homogeneous flows, or enhance capacity symmetric two-route scenario. However, feedback rarely...
Traffic safety accidents and events are easily happened on campus. A multiply information fusion method for supporting emergency management campus is proposed. This study analyzes the transportation characteristics road, difference between urban transportation, cause of traffic accident taking place frequently road. Moreover, this paper proposes a relative strategy preventing The abnormal conflict situations defined as events, these could be detected alarmed automatically by real-time...
Objectives Pancreatic carcinoid tumor (PCT) is described as a malignant form of tumors. However, the epidemiology and prognostic factors for PCT are poorly understood. Materials Methods The data 2447 patients were included in this study from Surveillance, Epidemiology, End Results database randomly divided into training cohort (1959) validation (488). was calculated, independent identified to construct nomogram predicting long-term disease-specific survival (DSS) among patients. incidence...
Abstract To explore the impacts of cytomegalovirus (CMV) infection and antiviral treatment (AVT) on native liver survival (NLS) in biliary atresia (BA) infants. This retrospective cohort study included infants diagnosed as BA between January 2015 December 2021 at Hunan Children's Hospital. CMV was defined by DNA polymerase chain reaction alone (DNA data set) combination immunoglobulin M (CMV set). In set 330 patients, 234 patients (70.9%) survived with their 2 years, 113 (73.9%) DNA− cohort,...
Objective To study the etiology, diagnosis, treatment and prognosis of neonatal gastrointestinal perforation. Methods From July 2010 to June 2014, medical records neonates with perforation admitted surgery intensive care unit were retrospectively reviewed.Their including demographic information, perioperative information analyzed compared between term preterm infants. Results Among 206 patients reviewed, 158 male 48 female, 119 infants 87 infants.The average birth weight...
Brain-derived neurotrophic factor is the ligands of tyrosine kinase receptor B,for binding brain-derived to B receptor,signal transmitted nucleus,resulting in a variety biological effects.Lots researchs had found that and expression malignant tumors more than non-cancerous adjacent tissue normal tissue,and their effect can promote tumor blood vessel formation,suppress cell anoikis,promote growth,differentiation metastasis.The relationship provide new therapeutic strategy for clinical...
BackgroundThis study aimed to evaluate the effectiveness of primary posterior tracheopexy (PPT) in reducing ventilator dependence after repair esophageal atresia (EA), and risk respiratory tract infections (RTI) requiring readmissions within one year.MethodsThis retrospective cohort recruited patients with EA admitted our hospital between June 2020 December 2021.ResultsIn PPT group (n = 17), time extubation surgery was 86.7 h for 12 patients, patient (8.3%) repeated postoperation intubation;...
Lymphocytic variant hypereosinophilic syndrome is a rare disease and the abnormal clonality of lymphocytes plays an important role in pathogenesis development lymphocytic syndrome. The recent progress were reviewed this article. Key words: Hypereosinophilic syndrome; Lymphocytic