A5085295350- Nanoplatforms for cancer theranostics
- Dermatologic Treatments and Research
- Glycosylation and Glycoproteins Research
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Laser Applications in Dentistry and Medicine
- Medical and Biological Ozone Research
- Photodynamic Therapy Research Studies
- Fungal Biology and Applications
- Antifungal resistance and susceptibility
- Carbohydrate Chemistry and Synthesis
- Galectins and Cancer Biology
- Cancer Research and Treatments
- Luminescence and Fluorescent Materials
- Inflammasome and immune disorders
- Adenosine and Purinergic Signaling
- Noise Effects and Management
- Electromagnetic Fields and Biological Effects
- Prenatal Screening and Diagnostics
- Fibroblast Growth Factor Research
- Ocular Infections and Treatments
- Orthopedic Infections and Treatments
Wenzhou Medical University
2017-2025
The First Affiliated Hospital, Sun Yat-sen University
2021-2025
Zhongshan Hospital
2021-2025
Fudan University
2021-2025
Sun Yat-sen University
2016-2025
Fujian Medical University
2024-2025
Jiangxi University of Technology
2025
Biomedical Research Institute
2025
Second Affiliated Hospital of Zhejiang University
2025
Taipei Medical University
2020-2024
Nanorobots with red blood cell–platelet hybrid membranes accelerated targeting and detoxification of biological threats.
Abstract Preventing and treating avascular necrosis at the distal end of flaps are critical to surgery success, but current treatments not ideal. A recent study shows that apoptotic bodies (ABs) generated near site apoptosis can be taken up promote cell proliferation. The reveals ABs derived from fibroblast‐like cells in subcutaneous connective tissue (FSCT cells) skin promoted ischaemic flap survival. It is also found inhibited death oxidative stress M1‐to‐M2 polarization macrophages....
Abstract Neutralization of bacterial toxins has become a compelling approach to treating infections as it may pose less selective pressure for the development resistance. Currently, majority toxin neutralization platforms act by targeting molecular structure toxin, which requires identification and customized design different diseases. Therefore, their been challenged enormous number complexity toxins. Herein, biomimetic nanosponges are formulated coating membranes human red blood cells...
The increasing popularity of biomimetic design principles in nanomedicine has led to therapeutic platforms with enhanced performance and biocompatibility. This includes the use naturally derived cell membranes, which can bestow nanocarriers cell-specific functionalities. Herein, we report on a strategy enabling efficient encapsulation drugs via remote loading into membrane vesicles from red blood cells. is accomplished by supplementing additional cholesterol, stabilizing nanostructure...
Endometriosis is a common, benign, and estrogen-dependent disease characterized by pelvic pain infertility. To date, the pathogenesis of endometriosis remains unclear. Recent studies have demonstrated that noncoding RNAs, including microRNAs long play important roles in development endometriosis.Expression profiling miRNAs endometrial tissue was using microarrays. The most differentially expressed were confirmed quantitative reverse transcriptase-polymerase chain reaction analysis additional...
Fine particulate matter (PM 2.5 ) is globally recognized for its adverse implications on human health. Yet, remain limited the individual contribution of particular PM components to toxicity, especially considering regional disparities. Moreover, prevention solutions -associated health effects are scarce. In present study, we comprehensively characterized and compared primary constituents their altered metabolites from two locations: Taiyuan Guangzhou. Analysis year-long samples revealed 84...
Phototherapy presents an effective approach for treating localized methicillin-resistant Staphylococcus aureus (MRSA) infections; however, the tradeoff between therapeutic efficacy and negative off-target effect persists. To address these issues, we have developed a nanoparticle-hydrogel superstructure comprising phototherapeutic liposomal nanobubbles (NB) fat extract (FE) encapsulated by F-127 hydrogel. After local administration to sites of MRSA infection, effectively neutralizes high...
Background Cordyceps militaris, an ascomycete caterpillar fungus, has been used as a traditional Chinese medicine for many years owing to its anticancer and immunomodulatory activities. Currently, artificial culturing of this beneficial fungus widely can meet the market, but systematic molecular studies on developmental stages cultured C. militaris at transcriptional translational levels have not determined. Methodology/Principal Findings We utilized high-throughput Illumina sequencing...
Ganoderma lucidum is a basidiomycete white rot fungus and of medicinal importance in China, Japan other countries the Asiatic region. To date, much research has been performed identifying ingredients lucidum. Despite its important therapeutic effects disease, little known about at genomic level. In order to gain molecular understanding this fungus, we utilized Illumina high-throughput technology sequence analyze transcriptome
As the most common nutritional disorder, iron deficiency represents a major public health problem with broad impacts on physical and mental development. However, treatment is often compromised by low bioavailability undesired side effects. Here, we report development of active mineral delivery vehicles using Mg-based micromotors, which can autonomously propel in gastrointestinal fluids, aiding dynamic minerals. Iron selenium are combined as model payload micromotor platform. We demonstrate...
Patients with acute kidney injury (AKI) who survive the stage are at notable risk for chronic disease (CKD) progression. There is no single therapy that can effectively prevent AKI to CKD transition. Autophagy a cytoplasmic component degradation pathway and has complex functions in several diseases, such as renal fibrosis. Previous research shown lactoferrin important antioxidant defense other systems, protecting kidneys against various injuries. The present study investigated effect of We...
Our previous studies suggest that human fat extract (FE) contains a variety of angiogenic factors and may provide an alternative treatment option for stroke. However, the therapeutic effect is largely limited due to its short half-life, inaccurate targeting.Herein, we leverage targeting abilities platelets (PLTs) lesion area stroke Arg-Gly-Asp (RGD) peptides blood vessels develop biomimetic nanocarrier capable delivering FE precisely treat The nanocarriers are comprised FE-encapsulated PLGA...
Phototherapy is an effective strategy to control Candida albicans (C. albicans) infection without raising the concern of drug resistance. Despite its effectiveness, a higher dose phototherapeutic power required for C. elimination compared bacteria that have be used, which readily accompanied by off-target heat and toxic singlet oxygen damage normal cells, thus limiting usefulness antifungal applications. Here overcome this, we develop "three-in-one" biomimetic nanoplatform consisting...
With its well-documented toxicity, the use of doxorubicin (Dox) for cancer treatment requires trade-offs between safety and effectiveness. This limited Dox also hinders functionality as an immunogenic cell death inducer, thus impeding usefulness immunotherapeutic applications. Here, we develop a biomimetic pseudonucleus nanoparticle (BPN-KP) by enclosing GC-rich DNA within erythrocyte membrane modified with peptide to selectively target healthy tissue. By localizing organs susceptible...
Background Agrocybe aegerita, the black poplar mushroom, has been highly valued as a functional food for its medicinal and nutritional benefits. Several bioactive extracts from A. aegerita have found to exhibit antitumor antioxidant activities. However, limited genetic resources hindered exploration of this species. Methodology/Principal Findings To facilitate research on we established deep survey transcriptome proteome mushroom. We applied high-throughput sequencing technology (Illumina)...
Abstract: Therapeutic antiangiogenesis strategies have demonstrated significant antitumor efficacy in ovarian cancer. Recently, RNA interference (RNAi) has come to be regarded as a promising technology for treatment of disease, especially In this study, vascular endothelial growth factor (VEGF)-small interfering (siRNA) was encapsulated into magnetic mesoporous silica nanoparticle (M-MSN)-based, polyethylenimine (PEI)-capped, polyethylene glycol (PEG)-grafted, fusogenic peptide...
A novel lectin was isolated from the mushroom Agrocybe aegerita (designated AAL-2) by affinity chromatography with GlcNAc (N-acetylglucosamine)-coupled Sepharose 6B after ammonium sulfate precipitation. The AAL-2 coding sequence (1224 bp) identified performing a homologous search of five tryptic peptides MS against translated transcriptome A. aegerita. molecular mass calculated to be 43.175 kDa MS, which consistent data amino acid sequence. To analyse carbohydrate-binding properties AAL-2,...
Abstract With few options available for the effective treatment of multidrug‐resistant bacteria, photodynamic therapy (PDT) has emerged as a promising therapeutic strategy that does not promote development antibiotic resistance. Unfortunately, beneficial bactericidal effect PDT is oftentimes accompanied by uncontrollable production reactive oxygen species. To overcome this issue, pore‐forming toxin (PFT)‐responsive biomimetic nanobubble designed, which constructed co‐encapsulating...