A5015172368- Pharmacogenetics and Drug Metabolism
- Analytical Methods in Pharmaceuticals
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects of Natural Compounds
- Analytical Chemistry and Chromatography
- Eicosanoids and Hypertension Pharmacology
- Heart rate and cardiovascular health
- Anesthesia and Sedative Agents
- Chronic Myeloid Leukemia Treatments
- Inflammatory mediators and NSAID effects
- Antifungal resistance and susceptibility
- Heart Rate Variability and Autonomic Control
- Pesticide Residue Analysis and Safety
- Drug Transport and Resistance Mechanisms
- Sesame and Sesamin Research
- Treatment of Major Depression
- Acute Lymphoblastic Leukemia research
- Berberine and alkaloids research
- Cancer, Stress, Anesthesia, and Immune Response
- Lung Cancer Research Studies
- Flavonoids in Medical Research
- Laser Applications in Dentistry and Medicine
- Advanced Nanomaterials in Catalysis
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced Photocatalysis Techniques
Wenzhou Medical University
2015-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2014-2024
Fuzhou University
2024
Wenzhou University
2015
Heritage Christian University
2007
Phototherapy presents an effective approach for treating localized methicillin-resistant Staphylococcus aureus (MRSA) infections; however, the tradeoff between therapeutic efficacy and negative off-target effect persists. To address these issues, we have developed a nanoparticle-hydrogel superstructure comprising phototherapeutic liposomal nanobubbles (NB) fat extract (FE) encapsulated by F-127 hydrogel. After local administration to sites of MRSA infection, effectively neutralizes high...
Cytochrome P450 2C9 (CYP2C9), one of the most important phase I drug metabolizing enzymes, could catalyze reactions that convert diclofenanc into diclofenac 4′-hydroxylation. Evaluation inhibitory effects compounds on CYP2C9 is clinically because inhibition result in serious drug–drug interactions. The objective this work was to investigate curcumin human and cytochrome 2C11 (CYP2C11) rat liver microsomes. results showed inhibited activity (10 µmol L–1 diclofenac) with half-maximal or a...
The present study aimed to investigate the effect of anlotinib (AL3818) on pharmacokinetics cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C6, CYP2D1, CYP2D2, and CYP3A1/2) by using five cocktail probe drugs in vivo. After pretreatment for 7 days with (treatment group) or saline (control oral administration, phenacetin, tolbutamide, omeprazole, metoprolol, midazolam were administered rats administration. Blood samples obtained at a series time-points concentrations plasma determined UHPLC-MS/MS...
The objective of this work was to investigate the effect orally administered genistein on pharmacokinetics imatinib and N-desmethyl in rats. Twenty-five healthy male SD (Sprague-Dawley) rats were randomly divided into five groups: A group (control group), B (multiple dose 100 mg/kg for consecutive 15 days), C 50 D (a single genistein), E genistein). is 30 min after administration (100 or mg/kg). pharmacokinetic parameters calculated by DAS 3.0 software. multiple significantly (<mml:math...
Abstract A sensitive and rapid ultra performance liquid chromatography tandem mass spectrometry (UPLC‐MS/MS) method was developed to determine voriconazole in human plasma. Sample preparation accomplished through a simple one‐step protein precipitation with methanol. Chromatographic separation carried out on an Acquity UPLC BEH C 18 column using isocratic mobile phase system composed of acetonitrile water containing 1% formic acid (45:55, v/v) at flow rate 0.50 mL/min. Mass spectrometric...
Corydalis decumbens, a Traditional Chinese Medicine, has been widely used for the alternative and/or complementary therapy of hypertension, arrhythmias rheumatoid arthritis, sciatica, stroke, hemiplegia, paraplegia, and vascular embolism. The aim this study was to determinate potential effects decumbens on five cytochrome P450 (CYP) enzyme activities (CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6) by cocktail approach. To evaluate whether concurrent use interferes with effect several prescription...
A sensitive and rapid UPLC-MS/MS method was developed to determine ivabradine, metoprolol their corresponding metabolites in rat plasma simultaneously.
Cytochrome P450 2D6 (CYP2D6) is a highly polymorphic enzyme that catalyzes the metabolism of great number therapeutic drugs. Up to now, >100 allelic variants CYP2D6 have been reported. Recently, we identified 22 novel in Chinese population these variants. The purpose this study was examine enzymatic activity toward substrate carvedilol vitro. proteins, including CYP2D6.1 (wild type), CYP2D6.2, CYP2D6.10, and other variants, were expressed from insect microsomes incubated with ranging 1.0 μM...
CYP2C9 is one of the most important phase I drug-metabolizing enzymes in liver. The objective this work was to investigate effects apigenin on metabolism losartan and human rat CYP2C11 activity vitro.Different concentrations were added a 100 mmol/l Tris-HCl reaction mixture containing 2 pmol/ml recombinant CYP2C9.1, 0.25 mg/ml liver microsomes or 0.5 determine half maximal inhibition half-maximal inhibitory concentration (IC50) losartan. In addition, diclofenac used as substrate performed...
Anlotinib is a novel inhibitor of receptor kinase tyrosine with multitargets and has broad spectrum inhibitory action on tumor angiogenesis growth. A simple rapid UHPLC-MS/MS bioanalytical method was validated for the determination anlotinib in rat plasma, using imatinib as an internal standard. An Acquity BEH C18 column used to separate analytes. The eluents consisted formic acid/water (0.1 : 100, v/v) acetonitrile mobile phase. triple quadrupole mass spectrometer operated quantification...
The present study aimed to investigate the effect of clopidogrel (CLO) on pharmacokinetics ivabradine (IVA) and its metabolite in rats develop a reliable method determine IVA N-demethyl serum. Healthy male SD were randomized be given 0.8 mg/kg or combined with 8 CLO. Blood samples collected at 0.083, 0.16, 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 24 h after administration. serum concentrations determined by ultra-performance liquid chromatography–mass spectrometry pharmacokinetic parameters...
1. This study aimed to investigate the inhibitory effect of azole antifungal agents, including ketoconazole, voriconazole, fluconazole, and itraconazole, on pharmacokinetics bosentan (BOS) its active metabolite hydroxy (OHBOS) in Sprague-Dawley (SD) rats.2. A total 25 healthy male SD rats were divided into five groups treated with various agents by gavage, followed a single dose BOS after 30 min.3. The found that ketoconazole led significant increase (5.1-fold) AUC(0-t) BOS, associated...
The present study aimed to develop and validate a rapid, selective, reproducible ultra-performance liquid chromatography-tandem mass spectrometry separation method for the simultaneous determination of levels parecoxib its main metabolite valdecoxib in rat plasma. Moreover, this was applied investigate pharmacokinetics rats. Following addition celecoxib as an internal standard, one-step protein precipitation by acetonitrile used sample preparation. effective chromatographic carried out using...