A5026289476- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Fungal Biology and Applications
- Receptor Mechanisms and Signaling
- Microbial Community Ecology and Physiology
- Ion channel regulation and function
- Galectins and Cancer Biology
- Hepatitis C virus research
- Glycosylation and Glycoproteins Research
- Liver Disease Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Genomics and Phylogenetic Studies
- Heart Rate Variability and Autonomic Control
- ECG Monitoring and Analysis
- Hepatitis B Virus Studies
- Cardiac pacing and defibrillation studies
- Plant tissue culture and regeneration
- Mycorrhizal Fungi and Plant Interactions
- Toxin Mechanisms and Immunotoxins
- Microbial Fuel Cells and Bioremediation
- Nanoplatforms for cancer theranostics
- Polysaccharides and Plant Cell Walls
- Nanoparticle-Based Drug Delivery
- Neuroscience and Neuropharmacology Research
Xiamen Tobacco Industry (China)
2024-2025
Sun Yat-sen University
2025
Xinxiang Medical University
2023
Dalian University of Technology
2021-2022
China Agricultural University
2021-2022
Dalian University
2021-2022
Xiamen University
2020-2021
Nanjing Medical University
2019
Jiangsu Province Hospital
2019
Northwestern University
2019
Background Cordyceps militaris, an ascomycete caterpillar fungus, has been used as a traditional Chinese medicine for many years owing to its anticancer and immunomodulatory activities. Currently, artificial culturing of this beneficial fungus widely can meet the market, but systematic molecular studies on developmental stages cultured C. militaris at transcriptional translational levels have not determined. Methodology/Principal Findings We utilized high-throughput Illumina sequencing...
Ganoderma lucidum is a basidiomycete white rot fungus and of medicinal importance in China, Japan other countries the Asiatic region. To date, much research has been performed identifying ingredients lucidum. Despite its important therapeutic effects disease, little known about at genomic level. In order to gain molecular understanding this fungus, we utilized Illumina high-throughput technology sequence analyze transcriptome
Abstract— We have previously shown that oxytocin receptors are present in the heart and perfusion of isolated rat hearts with results decreased cardiac flow rate bradycardia. The mechanisms involved negative inotropic chronotropic effects were investigated dog right atria absence central mechanisms. Perfusion through sinus node artery 10 −6 mol/L over 5 minutes (8 mL/min) significantly both beating (−14.7±4.9% basal levels, n=5, P <0.004) force contraction (−52.4±9.1% <0.001)....
Background Agrocybe aegerita, the black poplar mushroom, has been highly valued as a functional food for its medicinal and nutritional benefits. Several bioactive extracts from A. aegerita have found to exhibit antitumor antioxidant activities. However, limited genetic resources hindered exploration of this species. Methodology/Principal Findings To facilitate research on we established deep survey transcriptome proteome mushroom. We applied high-throughput sequencing technology (Illumina)...
A novel lectin was isolated from the mushroom Agrocybe aegerita (designated AAL-2) by affinity chromatography with GlcNAc (N-acetylglucosamine)-coupled Sepharose 6B after ammonium sulfate precipitation. The AAL-2 coding sequence (1224 bp) identified performing a homologous search of five tryptic peptides MS against translated transcriptome A. aegerita. molecular mass calculated to be 43.175 kDa MS, which consistent data amino acid sequence. To analyse carbohydrate-binding properties AAL-2,...
Nano graphene oxide (NGO) has high drug-loading capacity due to its huge surface area. However, the limited stability and poor biocompatibility of NGO hampered application as drug delivery carrier under physiological conditions. Thereby, a new strategy using chemical conjugation on with hydrophilic polymers was adopted but currently too complicated, low yield costly. In this study, doxorubicin-hyd-PEG-folic acid (DOX-hyd-PEG-FA) were coated via π–π stocking hydrophobic effect between DOX...
Ganoderma lucidum is a basidiomycete white rot fungus that has been used for medicinal purposes worldwide. Although information concerning its genome and transcriptome recently reported, relatively little available G. at the proteomic level. In this study, protein fractions from three developmental stages (16-day mycelia, fruiting bodies 60 90 days) were prepared subjected to LC-MS/MS analysis. A search against database identified 803 proteins. Among these proteins, 61 lignocellulose...
CRISPR/Cas9 system has been used as the most powerful gene editing tool for precision medicine and advanced therapy. However, its wide applications are limited by poor biosafety of lentivirus delivery vectors though with high-efficiency transduction. To construct a safer vector promote genome integration, is cloned into plasmid-based non-viral safe Sleeping-Beauty (SB) transposon in this study to obtain pT2SpCas9. Meanwhile, PDA/DEX-PEI@HA (PDPH) nanoparticles constructed facilitate precise...
Electrogram analysis is important in clinical and experimental settings. Activation recovery interval (ARI) has been used to measure ventricular action potential duration (APD) but its suitability for the atria not addressed. Mapping of atrial repolarization may be especially during nerve stimulation since large heterogenous APD changes manifest. This study assessed utility estimating using electrograms. A computer model was compute Two different waveforms were used, as well two ventricular....
Scope Mushrooms are well known for their nutritional and medicinal value. Agrocybe aegerita has been used as a nutritious food around the world its herbal properties in Asia. In recent years, several antitumor proteins have identified from A. . The objective of this study was to purify novel protein Methods results A deoxyribonuclease (AAD) purified through two‐step chromatographic procedure shown possess activity against different cancer cell lines. Cells treated with AAD produced typical...
O-linked N-acetylglucosamine (O-GlcNAcylation) is an important post-translational modification on serine or threonine of proteins, mainly observed in nucleus cytoplasm. O-GlcNAcylation regulates many cell processes, including transcription, cycle, neural development and nascent polypeptide chains stabilization. However, the facile identification O-GlcNAc a major bottleneck research. Herein, we report that lectin, Agrocybe aegerita GlcNAc-specific lectin (AANL), also reported as AAL2, can be...
Because surprising similarities exist between the cardiac effects of amiodarone and those observed during hypothyroidism, we tested three different mechanisms action in rats to determine whether might act by inducing a tissular hypothyroidism: (a) decrease thyroid secretion, (b) an inhibiting effect on conversion thyroxine (T4) 3,5,3′ triiodothyronine (T3), (c) direct antagonistic cellular T3. Five groups rats, treated orally for 7 or 13 days, were studied: I, control (0.5 ml saline n = 14);...
To assess if the anti-beta-adrenergic effect and bradycardia induced by amiodarone were mediated thyroid hormone, we investigated these effects of in euthyroid hypothyroid rats. We studied control rats, thyroidectomized rats treated with (50 mg/kg for 8 days), amiodarone. At end treatment, free hormone levels (FT4 FT3) determined, cardiac beta-receptor density (Bmax) affinity (Kd) assayed using (-)-[125I]iodocyanopindolol as radioligand. Resting heart rate (rHR) was also assessed every day...