A5041368746- Angiogenesis and VEGF in Cancer
- Erythrocyte Function and Pathophysiology
- Axon Guidance and Neuronal Signaling
- Thyroid Disorders and Treatments
- Lipid Membrane Structure and Behavior
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Glycosylation and Glycoproteins Research
- Colorectal Cancer Screening and Detection
- Estrogen and related hormone effects
- Genetic factors in colorectal cancer
- Nanoparticle-Based Drug Delivery
- Drug Transport and Resistance Mechanisms
- Nitric Oxide and Endothelin Effects
- Proteoglycans and glycosaminoglycans research
- Radiopharmaceutical Chemistry and Applications
- Adipose Tissue and Metabolism
- Neonatal Health and Biochemistry
- Bone health and treatments
- Diet and metabolism studies
- Pharmacogenetics and Drug Metabolism
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Cancer Research and Treatments
Université Sorbonne Paris Nord
2008-2019
Inserm
1983-2019
Sorbonne Paris Cité
2014-2019
Université Paris Cité
2003-2019
Association pour la Recherche en Physiologie de l’Environnement
1983-2016
Centre National de la Recherche Scientifique
2006-2012
Hôpital Necker-Enfants Malades
2012
Physiopathologie, cibles et thérapies de la polyarthrite rhumatoïde
2011
Laboratoire de Chimie
2011
Hôpital Avicenne
1996-2010
Therapeutic induction of angiogenesis is a potential treatment for chronic ischemia. Heparan sulfate proteoglycans are known to play an important role by their interactions with proangiogenic growth factors such as vascular endothelial factor (VEGF). Low molecular weight fucoidan (LMWF), sulfated polysaccharide from brown seaweeds that mimic some biological activities heparin, has been shown recently promote revascularization in rat critical hindlimb In this report, we first used cultured...
The causes of transient hypocalcemia after thyroid surgery are not fully understood. In 95 consecutive patients undergoing total thyroidectomy (n = 30), subtotal 14), or hemithyroidectomy 51), we serially measured calcium, parathyroid hormone (PTH), and proteins before 6, 24, 48, 72, 96 hours surgery, calculated the corresponding ionized calcium levels. whole population, there was a statistically significant decrease PTH, at nearly every time blood withdrawal, when compared with preoperative...
Nephrotic syndrome in minimal change lipoid nephrosis and focal segmental glomerulosclerosis may be due to alteration of glomerular anionic sites by a lymphokine. Six adults with nephrotic who were resistant treatment corticosteroids immunosuppressants treated cyclosporin A. In three patients had been for 3.5 23 years proteinuria resolved within 12 42 days. Subsequently, these became dependent on four six mean (SD) 24 hour urinary protein decreased from 14.7 (8.4) g 3.6 (0.6) 20 25 days,...
SUMMARY A study of hypothalamo‐pituitary function was carried out in chronic alcoholic women aged 29–66 years, with pancreatitis or cirrhosis the liver. Amenorrhoea present most them (67%). The hormonal investigation included assessment basal plasma steroids, gonadotrophin and prolactin values, followed by an anterior pituitary test. Clomiphene stimulation and/or hCG tests were performed. subjects divided into four groups according to their oestrogen status on one hand, baseline...
Abstract The CC-chemokine regulated on activation, normal T-cell expressed, and presumably secreted (RANTES)/CCL5 mediates its biological activities through activation of G protein–coupled receptors, CCR1, CCR3, or CCR5, binds to glycosaminoglycans. This study was undertaken investigate whether this chemokine is involved in hepatoma cell migration invasion modulate these effects vitro by the use glycosaminoglycan mimetics. We show that human Huh7 Hep3B cells express RANTES/CCL5 receptor CCR1...
The existence of multiple VEGF-A isoforms raised the possibility that they may have distinct functions in tumor growth. We previously published VEGF189 and VEGF165 contribute to breast cancer progression angiogenesis, but induced most rapid uptake. Since has been described as a survival factor for cells, we questioned here effects on survival/apoptosis MDA-MB-231 cells. used clones which overexpress (V189) or (V165) compared them control one (cV). Overexpression resulted increased cell...
We have recently reported that the CXC-chemokine stromal cell-derived factor-1 (SDF-1)/CXCL12 induces proliferation, migration, and invasion of Huh7 human hepatoma cells through its G-protein-coupled receptor CXCR4 glycosaminoglycans (GAGs) are involved in these events. Here, we demonstrate by surface plasmon resonance chemokine binds to GAG mimetics obtained grafting carboxylate, sulfate or acetate groups onto a dextran backbone. also chemically modified dextrans inhibit...