A5100346679- Reconstructive Surgery and Microvascular Techniques
- Orthopedic Surgery and Rehabilitation
- Reconstructive Facial Surgery Techniques
- Cancer Treatment and Pharmacology
- Bone fractures and treatments
- Breast Cancer Treatment Studies
- Hematopoietic Stem Cell Transplantation
- Surgical Sutures and Adhesives
- Medical Research and Treatments
- T-cell and B-cell Immunology
- Cardiomyopathy and Myosin Studies
- Anesthesia and Pain Management
- Gastric Cancer Management and Outcomes
- Head and Neck Surgical Oncology
- Neuropeptides and Animal Physiology
- Musculoskeletal synovial abnormalities and treatments
- Immunotherapy and Immune Responses
- Pain Mechanisms and Treatments
- Atrial Fibrillation Management and Outcomes
- Spine and Intervertebral Disc Pathology
- Radiomics and Machine Learning in Medical Imaging
- Heart Failure Treatment and Management
- Acute Myeloid Leukemia Research
- Peripheral Nerve Disorders
- Cerebrovascular and Carotid Artery Diseases
Capital Medical University
2009-2025
Nanjing General Hospital of Nanjing Military Command
2008-2025
Nanjing University
2008-2025
Yangzhou University
2014-2024
Second Hospital of Yichang
2022-2024
Dalian Medical University
2024
Northern Jiangsu People's Hospital
2019-2024
China Three Gorges University
2021-2024
Shandong Provincial Hospital
2009-2024
Shandong First Medical University
2024
Impaired or deficient autophagy is believed to cause contribute aging, as well a number of age-related pathologies. The exact mechanism through which alterations in induce these various pathologies not understood. Here we describe the creation two vivo mouse models that allow for characterization alteration mitochondrial function and contribution corresponding oxidative stress following deletion Atg7. Using demonstrate isolated mitochondria obtained from Atg7-/- skeletal muscle exhibit...
<b><i>Objective:</i></b> Obesity-related disease risks may vary depending on whether the subject has metabolically healthy obesity (MHO) or unhealthy (MUO). At least 5 definitions/criteria of and metabolic disorders have been documented in literature, yielding uncertainties a reliable international comparison phenotype prevalence. This report aims to compare differences MHO MUO prevalence according most frequently used definitions.<b><i>...
Abstract We reported that both donor CD4+ T and B cells in transplants were required for induction of an autoimmune-like chronic graft-versus-host disease (cGVHD) a murine model DBA/2 to BALB/c recipient, but mechanisms whereby augment cGVHD pathogenesis remain unknown. In this study, we report that, although have little impact on acute GVHD severity, they play important role augmenting the persistence tissue damage overlapping target organs (i.e., skin lung); also markedly prototypical...
Increasing evidence suggests that beta-blocker use might be associated with reduced mortality in prostate cancer patients. To provide a quantitative assessment of this association, we pooled data available to examine the association between and cancer.We identified studies by literature search MEDLINE (from 1 January 1966) EMBASE 1974), through 10 September 2014, searching reference lists pertinent articles. Two authors independently screened reviewed eligibility each study. The primary...
In Brief Recent studies reported the translocator protein (TSPO) to play critical roles in several kinds of neurological diseases including inflammatory and neuropathic pain. However, precise mechanism remains unclear. This study was undertaken explore distribution possible spinal TSPO against chronic pain (CNP) a rat model L5 nerve ligation (SNL). Our results showed that upregulated time-related manner dorsal horn after SNL. Spinal predominately expressed astrocytes. A single intrathecal...
The associations between metabolic dysfunction-associated fatty liver disease (MAFLD) and cancer development, especially extrahepatic cancers, are unknown. aims of the current study were to investigate incidence rates MAFLD analyze development cancers.This historical cohort included participants who underwent ultrasonographic detection hepatic steatosis at a tertiary hospital in China from January 2013 October 2021. was diagnosed accordance with International Expert Consensus Statement. Cox...
Abstract Foxp3+ regulatory T (Treg) cells include thymic-derived natural Treg and conventional T-derived adaptive cells. Both are proposed to play important roles in downregulating inflammatory immune responses. However, the mechanisms of expansion environments remain unclear. In this study, we report that, an autoimmune-like graft-versus-host disease model DBA/2 (H-2d) donor BALB/c recipients, recipients predominantly originated from few vivo neutralization IFN-γ resulted a marked reduction...
Perioperative chemotherapy is a potential treatment for locally advanced gastric cancer. However, the optimal regimen remains unknown.To investigate safety and efficacy of S-1 plus oxaliplatin (SOX) vs fluorouracil, leucovorin, (FOLFOX) as perioperative patients with cancer.In this phase 3, open-label, multicenter, randomized clinical trial, from 12 Chinese hospitals were enrolled between June 2011 August 2016, last follow-up date September 2019. The primary tumor was evaluated either...
Combination therapy that induces mixed chimerism and augments both β cell neogenesis replication reverses late-stage type 1 diabetes in NOD mice.
Hematopoietic stem cells (HSCs) reside in a specialized bone marrow (BM) microenvironment that supports the maintenance and functional integrity of long-term (LT)-HSCs throughout postnatal life. The objective this work is to study role activated leukocyte cell adhesion molecule (Alcam) HSC differentiation self-renewal using an Alcam-null (Alcam(-/-) ) mouse model. We show here Alcam differentially regulated adult hematopoiesis highly expressed LT-HSCs where its level progressively increases...
We assessed the effect of asymptomatic carotid atherosclerosis (CAS) on development cardiovascular diseases (CVDs) in a community-based population aged ≥55 years China. A total 1376 residents underwent CAS assessment by ultrasonography July 2009. New CVD events, including stroke and coronary heart were collected at follow-up survey end 2014. After adjusting for baseline demographic characteristics traditional risk factors, patients with minimal (mean common artery intima–media thickness...
To develop the crosswalk between Montreal Cognitive Assessment-Basic (MoCA-B) and Mini-Mental Status Examination (MMSE) based on a community-dwelling older population to facilitate data synthesis comparison. A cross-sectional study. We used baseline of 2170 subjects with total MoCA-B MMSE scores from an ongoing prospective cohort study, Beijing Longitudinal Disability Survey in Community Elderly (BLINDSCE). The were administered by trained assessors. Equipercentile equating was conversion...
Tophus, a hallmark feature of chronic gout, typically develops in the joints extremities, skin, and mucosal tissues. Although several case reports have described spinal tophus deposition leading to stenosis radiculopathy, documented cases lumbar adjacent segment disease (ASD) caused by monosodium urate crystal (MUC) remain exceedingly rare. Here, we report 56-year-old male who underwent L4-S1 fusion surgery two years prior for disc herniation with radiculopathy. The patient presented...
The rapidly expanding population of ageing and older adults with disability has been a continuing public health priority in recent decades. first step towards solving this issue is to assess accurately identify high-risk factors individuals for early prevention. We aim establish prospective cohort, the Beijing Longitudinal Disability Survey Community Elderly (BLINDSCE), using multidimensional assessments develop multifactorial models prediction among community-dwelling adults. BLINDSCE...
Allergic rhinitis (AR) is one of the common disorders in airway allergic inflammation. The pathogenesis AR unclear. It accepted that immune deregulation associated with AR. Recent reports suggest a large number micro RNAs (miR) can regulate functions. This study aims to investigate role miR-146a an enforcing immunotherapy In this study, mouse model was created. levels nasal mucosa were assessed by real time RT-PCR. A specific performed mice. results showed mice had AR-like inflammation...
Short-term spinal cord stimulation (st-SCS) has been widely used to treat herpetic-related neuralgia (HN) in China for several years, but is still heavily debated as it no strong evidence clinical application. Therefore, a questionnaire survey among the Chinese pain specialist workgroup of Neuromodulation Society and Medical Doctor Association was carried out achieve consensus about use st-SCS HN treatment.The contents include basic information doctors (hospital level, work experience,...
Background: Due to the rarity of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome, best first-line treatment has not been established, although there are several options in guidelines. The preferred treatments vary according preference physician anecdote. Objectives: First, analyze efficacy a new mode POEMS syndrome that uses four-cycle as induction regimen, followed by sequential transplantation consolidation regimen for...
Lumbar disc herniation (LDH) usually c auses sciatica. Although selective nerve root block (SNRB) is an effective, highly target-oriented interventional procedure for patients with LDH, accurately predicting the risk of sciatica recurrence in such after SNRB remains a major challenge. We aimed to construct nomogram model by integrating clinical data, imaging features and inflammation markers that could predict recurrent following LDH patients, which fill data gaps during construction. In...