A5034232787- ECG Monitoring and Analysis
- Cardiac Arrhythmias and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Phonocardiography and Auscultation Techniques
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Cardiac Arrest and Resuscitation
- Diabetes and associated disorders
- Atrial Fibrillation Management and Outcomes
- Autoimmune and Inflammatory Disorders Research
- Adenosine and Purinergic Signaling
- Cardiac Imaging and Diagnostics
- Heart Rate Variability and Autonomic Control
- Vascular Anomalies and Treatments
- Immunodeficiency and Autoimmune Disorders
- PI3K/AKT/mTOR signaling in cancer
- T-cell and B-cell Immunology
- Cardiac electrophysiology and arrhythmias
- Pancreatic function and diabetes
- Infective Endocarditis Diagnosis and Management
- Systemic Lupus Erythematosus Research
- Cardiac Structural Anomalies and Repair
- Non-Invasive Vital Sign Monitoring
Scripps Clinic
2019-2025
Scripps Health
2022-2024
San Diego Cardiac Center
2024
Institute of Cardiology
2022
Center for Advancing Health
2021
Medical College of Wisconsin
2021
Scripps Institution of Oceanography
2020
Scripps (United States)
2020
Scripps Research Institute
2019
Loma Linda University
2015-2017
Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that belongs to the Transforming Growth Factor-β (TGF-β) superfamily proteins. Initially discovered for their ability induce bone formation, BMPs now known play crucial roles in all organ systems. important embryogenesis and development, also maintenance adult tissue homeostasis. Mouse knockout models various components BMP pathway result embryonic lethality or marked defects, highlighting essential functions BMPs. In this...
To determine why methotrexate (MTX) exacerbates rheumatoid nodules in some patients, despite the effective suppression of synovial inflammation.Phorbol myristate acetate (PMA)-induced differentiation monocytes into multinucleated giant cells was used as an vitro model to study effects adenosine on nodulosis.MTX at 200-2,000 nM or A1 agonist N5-cyclopentyl (CPA) (10(-12) 10(-9) M) A2 antagonist 3,7-dimethyl-1-propargylxanthine markedly enhanced cell formation, whereas...
In examining reasons for premature atherosclerosis in systemic lupus erythematosus (SLE), we previously reported low levels of the cholesterol transport protein apolipoprotein A1 (apoA1) these patients, and specific antibodies to purified apoA1 were identified sera 5 out 30 patients. The current study was initiated determine whether are common 520 serum samples from 175 patients with SLE or primary antiphospholipid syndrome (PAPS) tested apoA1. Positive retested binding incorporated into...
Combination therapy that induces mixed chimerism and augments both β cell neogenesis replication reverses late-stage type 1 diabetes in NOD mice.
Despite nearly universal expression of the wild‐type epidermal growth factor receptor (EGFR) and reproducible activity EGFR inhibitors in patients with squamous cell carcinoma head neck (SCCHN), majority will not have objective responses. The mechanisms this intrinsic resistance are well established. We hypothesized that sensitivity to can be predicted based on inhibitors' effects downstream signaling. Cell viability assays were used assess inhibitor gefitinib (ZD1839) 8 SCCHN lines....
Background Diagnosis of shockable rhythms leading to defibrillation remains integral improving out-of-hospital cardiac arrest outcomes. New machine learning techniques have emerged diagnose arrhythmias on ECGs. In arrest, an algorithm within automated external defibrillator is the major determinant deliver defibrillation. This study developed and validated performance a convolution neural network (CNN) novel, miniaturized defibrillator. Methods Results There were 26 464 single-lead ECGs that...
Abstract In nonautoimmune recipients, induction of mixed and complete chimerism with hematopoietic progenitor cells from MHC (HLA)-matched or -mismatched donors are effective approaches for organ transplantation immune tolerance in both animal models patients. But it is still unclear whether this the case autoimmune recipients. With diabetic NOD mouse model, we report that, although MHC-mismatched provide to donor-type islet skin transplants, neither nor MHC-matched does. The not only...
To investigate immunoreactivity of systemic lupus erythematosus (SLE) sera with apolipoprotein A1, (Apo A1), the major lipid-binding protein high-density lipoprotein (HDL).Since early attempts to identify Apo A1 autoantibodies using standard enzyme-linked immunosorbent assay (ELISA) and immunoblotting techniques had been unsuccessful, a mouse complementary DNA lambda phage expression library was screened.A selected clone (MA1) found have 82% sequence homology segment human A1. Since there...
Human bodily mechanisms and functions produce low-frequency vibrations. Our ability to perceive these vibrations is limited by our range of hearing. However, in-ear infrasonic hemodynography (IH) can measure (<20 Hz) created vital organs as an acoustic waveform. This captured using a technology that be embedded into wearable devices such headphones. IH acquire sound signals travel within arteries, fluids, bones, muscles in proximity the ear canal, allowing for measurements individual's...
Long-term hypoxia (LTH) has a profound effect on pulmonary arterial vasoconstriction in the fetus and adult. Dysregulation Ca2+ signaling is important during development of LTH-induced hypertension. In present study, we tested hypothesis that L-type channels (CaL), which are voltage dependent found smooth, skeletal, cardiac muscle, adaptation contractions postnatal maturation response to LTH. Pulmonary arteries were isolated from fetal or adult sheep maintained at low high altitude (3,801 m)...
Abstract Type 1 diabetic NOD mice have defects in both thymic negative selection and peripheral regulation of autoreactive T cells, induction mixed chimerism can effectively reverse these defects. Our recent studies suggest that MHC-mismatched mediates thymocytes wild-type TCR-transgenic NOD.Rag1+/+.BDC2.5 mice. However, it remains unknown how mismatched I-Ab MHC class II mediate deletion cells positively selected by I-Ag7. In the present study, we directly tested hypothesis chimeras...
Abstract Objective . To determine why methotrexate (MTX) exacerbates rheumatoid nodules in some patients, despite the effective suppression of synovial inflammation. Methods Phorbol myristate acetate (PMA)‐induced differentiation monocytes into multinucleated giant cells was used as an vitro model to study effects adenosine on nodulosis. Results. MTX at 200‐2,000 n M or A 1 agonist N 5 ‐cyclopentyl (CPA) (10 −12 10 ‐9 ) 2 antagonist 3,7‐dimethyl‐1‐propargylxanthine markedly enhanced cell...
An 88-year-old man with small lymphocytic lymphoma presented to the hospital shortness of breath and was diagnosed heart failure. Serial blood cultures echocardiography revealed Staphylococcus epidermidis endocarditis, complicated by severe aortic regurgitation. Despite intravenous antibiotic therapy aggressive diuresis in hospital, he decompensated into cardiogenic shock, requiring invasive haemodynamic monitoring inotrope therapy. With multidisciplinary discussion involving patient his...
Increasing prostaglandin E2 by knocking out its inhibitor 15-hydroxyprostaglandin dehydrogenase (15-PDGH) or administering a compound that inhibits 15-PDGH was recently found to improve healing in hematopoietic stem cell transplants, colitis recovery, and hepatogenesis after transection mice. These results are suggestive of pharmacologic therapies even genetic therapy could patient outcomes, especially since the excess PGE2 have proven be non-toxic. However, elevated levels associated with...
Methotrexate is one of the most effective and widely used medications in treatment rheumatoid arthritis. One poorly understood side effect methotrexate increased nodule formation, a phenomenon which has been reported to occur some patients despite suppression synovial inflammation. Using an vitro model nodulosis, induction monocyte differentiation into multinucleated giant cells, we previously found that promotes this inflammatory response by mechanism dependent on adenosine A1 receptor...
Noninvasive infrasonic hemodynography using the MindMics earbuds captures low-frequency acoustic vibrations throughout cardiac cycle. In an n-of-1 analysis, we propose a new method of assessing severe aortic stenosis by to detect its characteristic systolic ejection murmur before and after transcatheter valve replacement.