A5049507950- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- ECG Monitoring and Analysis
- CAR-T cell therapy research
- Radiomics and Machine Learning in Medical Imaging
- Cardiac electrophysiology and arrhythmias
- EEG and Brain-Computer Interfaces
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Non-Invasive Vital Sign Monitoring
- Phonocardiography and Auscultation Techniques
AGH University of Krakow
2022
Human bodily mechanisms and functions produce low-frequency vibrations. Our ability to perceive these vibrations is limited by our range of hearing. However, in-ear infrasonic hemodynography (IH) can measure (<20 Hz) created vital organs as an acoustic waveform. This captured using a technology that be embedded into wearable devices such headphones. IH acquire sound signals travel within arteries, fluids, bones, muscles in proximity the ear canal, allowing for measurements individual's...
Abstract Cellular immunotherapies, such as those utilizing T lymphocytes expressing native or engineered cell receptors (TCRs), have already demonstrated therapeutic efficacy. However, some high-affinity TCRs also proved to be fatal due off-target immunotoxicity. This process occurs when the immune system acts against epitopes found on both tumor cells and healthy tissues. Moreover, can cross-reactive with highly dissimilar sequences. To address this issue, we developed ARDitox, a novel in...
Developing innovative precision and personalized cancer therapeutics is essential to enhance survivability, particularly for prevalent types such as colorectal cancer. This study aims demonstrate various approaches discovering new targets therapies using artificial intelligence (AI) on a Polish cohort of patients.
Abstract Isolation of MHC ligands and subsequent analysis by mass spectrometry is considered the gold standard for defining targets TCR-T immunotherapies. However, as many high tumor-specificity are only presented at low abundance on cell surface tumor cells, efficient isolation these peptides crucial their successful detection. Here, we demonstrate how different strategies, which consider hydrophobicity post-translational modifications, can improve detection ligands, including cysteinylated...