A5006021560- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Advanced MRI Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Coronary Artery Anomalies
- Cardiac Arrhythmias and Treatments
- Cardiovascular Issues in Pregnancy
- Aortic Disease and Treatment Approaches
- Ultrasound in Clinical Applications
- Cardiovascular Disease and Adiposity
- Mechanical Circulatory Support Devices
- Hemodynamic Monitoring and Therapy
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Cardiovascular and Diving-Related Complications
- Heart Failure Treatment and Management
- Ultrasound and Hyperthermia Applications
- Vascular anomalies and interventions
- Cardiovascular Effects of Exercise
- Cardiovascular Conditions and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Transplantation: Methods and Outcomes
Johns Hopkins Hospital
2018-2025
Johns Hopkins University
2018-2025
Johns Hopkins Children's Center
2018-2025
Johns Hopkins Medicine
2018-2025
BayCare Health System
2025
Children's Hospital & Medical Center
2014-2024
University of Nebraska Medical Center
2015-2024
Phoenix Children's Hospital
2024
Skåne University Hospital
2023
Lund University
2023
Cytokine storm is an acute hyperinflammatory response that may be responsible for critical illness in many conditions including viral infections, cancer, sepsis, and multi-organ failure. The phenomenon has been implicated critically ill patients infected with SARS-CoV-2, the novel coronavirus COVID-19. Critically COVID-19 experiencing cytokine are believed to have a worse prognosis increased fatality rate. In SARS-CoV-2 patients, appears important pathogenesis of several severe...
Cardiovascular Magnetic Resonance myocardial feature tracking (CMR-FT) is a quantitative technique tissue voxel motion on standard steady-state free precession (SSFP) cine images to assess ventricular deformation. The importance of left atrial (LA) deformation assessment increasingly recognized and can be assessed with echocardiographic speckle tracking. However quantification has never previously been demonstrated CMR. We sought determine the feasibility reproducibility CMR-FT for...
Cardiovascular magnetic resonance myocardial feature tracking (CMR-FT) is a recently described method of post processing routine cine acquisitions which aims to provide quantitative measurements circumferentially and radially directed ventricular wall strain. Inter-study reproducibility important for serial assessments however has not been defined CMR-FT. 16 healthy volunteers were imaged 3 times within single day. The first examination was performed at 0900 after fasting immediately...
Dobutamine stress cardiovascular magnetic resonance (DS-CMR) is an established tool to assess hibernating myocardium and ischemia. Analysis typically based on visual assessment with considerable operator dependency. CMR myocardial feature tracking (CMR-FT) a recently introduced technique for tissue voxel motion standard steady-state free precession (SSFP) images derive circumferential radial mechanics. We sought determine the feasibility reproducibility of CMR-FT quantitative wall during...
Patients with repaired tetralogy of Fallot are monitored for pulmonary regurgitation (PR) and right ventricular (RV) function. We sought to compare measures PR RV function on echocardiogram those cardiac magnetic resonance (CMR) develop a new tool assessing by echocardiogram.Patients (n=143; 12.5±3.2 years) had an CMR within 3 months each other. On echocardiogram, was assessed (1) Doppler tissue imaging the free wall (2) myocardial performance index. The ratio diastolic systolic...
Hepatic dysfunction is a recognized complication after Fontan palliation of congenital heart disease. We sought to quantitatively measure hepatic stiffness and vascular Doppler indices using ultrasound (US) shear wave elastography (SWE) in cohort. Subjects were prospectively recruited for echocardiography real-time duplex US with SWE (kPa). peak velocities, velocity time integral, resistive, pulsatility, acceleration (RI, PI, AI), flow volume measured celiac artery, superior mesenteric main...
Rationale: Right ventricular (RV) fibrosis in pulmonary arterial hypertension contributes to RV failure. While reflects changes the function of resident fibroblasts (RVfib), these cells are understudied. Objective: Examine role mitochondrial metabolism RVfib human and experimental hypertension. Methods Results: Male Sprague-Dawley rats received monocrotaline (MCT; 60 mg/kg) or saline. Drinking water containing no supplement PDK (pyruvate dehydrogenase kinase) inhibitor dichloroacetate was...
Right heart catheterization using exercise stress is the reference standard for diagnosis of failure with preserved ejection fraction (HFpEF) but carries risk invasive procedure. We hypothesized that real-time cardiac magnetic resonance (RT-CMR) imaging pathophysiologic data at excellent temporal and spatial resolution may represent a contemporary noninvasive alternative diagnosing HFpEF.The HFpEF-Stress trial (CMR Exercise Stress Testing in HFpEF; URL: https://www.clinicaltrials.gov; Unique...
Prenatal detection (PND) has benefits for infants with hypoplastic left heart syndrome (HLHS) and transposition of the great arteries (TGA), but associations between sociodemographic geographic factors PND have not been sufficiently explored. This study evaluated whether socioeconomic quartile (SEQ), public insurance, race ethnicity, rural residence, distance residence (distance driving time from a cardiac surgical center) are associated or timing PND, secondary aim to analyze differences...