Kazuko Tajiri
A5026699562- Atrial Fibrillation Management and Outcomes
- Chemotherapy-induced cardiotoxicity and mitigation
- Viral Infections and Immunology Research
- Cancer Immunotherapy and Biomarkers
- Cardiac electrophysiology and arrhythmias
- Cardiac Fibrosis and Remodeling
- Cardiac Imaging and Diagnostics
- CAR-T cell therapy research
- Cardiac Arrhythmias and Treatments
- Cell Adhesion Molecules Research
- Cardiovascular Effects of Exercise
- Cardiac tumors and thrombi
- Takotsubo Cardiomyopathy and Associated Phenomena
- Peptidase Inhibition and Analysis
- Cardiovascular Function and Risk Factors
- Cytokine Signaling Pathways and Interactions
- Atherosclerosis and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Melanoma and MAPK Pathways
- Cardiac Structural Anomalies and Repair
- Pericarditis and Cardiac Tamponade
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Acute Myocardial Infarction Research
- Renal and Vascular Pathologies
University of Tsukuba
2016-2025
National Cancer Center Hospital East
2022-2025
National Institute of Biomedical Innovation, Health and Nutrition
2012-2021
Vanderbilt University Medical Center
2021
Pitié-Salpêtrière Hospital
2021
Sorbonne Université
2021
Ipsen (France)
2021
Janssen (Switzerland)
2021
Montreal Heart Institute
2019-2020
Université de Montréal
2019
Rev-erb α, known as nuclear receptor 1D1 (NR1D1), regulates circadian rhythm, modulates glucose and lipid metabolism, inflammatory response. However, little is about the effect of agonist on progression myocardial infarction (MI) heart failure. To investigate it, wild-type male mice underwent sham-operation or permanent ligation left anterior descending coronary artery to create MI model. SR9009 (100 mg/kg/day) vehicle was intraperitoneally administered. Echocardiography performed evaluate...
Tenascin-C (TN-C), an extracellular matrix glycoprotein, appears at several important steps of cardiac development in the embryo, but is sparse normal adult heart. TN-C re-expresses under pathological conditions including myocarditis, and closely associated with tissue injury inflammation both experimental clinical settings. However, pathophysiological role myocarditis not clear. We examined how affects initiation autoimmune immunologically.A model was established BALB/c mice by immunization...
In the present study, we aimed to investigate whether early cardiac biomarker alterations and echocardiographic parameters, including left atrial (LA) strain, can predict anthracycline-induced cardiotoxicity (AIC) thus develop a predictive risk score.
Abstract Aims Tenascin-C (TN-C) is an extracellular matrix protein undetected in the normal adult heart, but expressed several heart diseases associated with inflammation. We previously reported that serum TN-C levels of myocardial infarction (MI) patients were elevated during acute stage, and high peak at risk left ventricular (LV) remodelling poor outcome, suggesting could play a significant role progression remodelling. However, detailed molecular mechanisms this process remain unknown....
Neutrophils are recruited into the heart at an early stage following a myocardial infarction (MI). These secrete several proteases, one of them being neutrophil elastase (NE), which promotes inflammatory responses in disease models. It has been shown that there is increase NE activity patients with MI; however, role MI remains unclear. Therefore, present study aimed to investigate pathogenesis mice. expression peaked on day 1 infarcted hearts. In addition, deficiency improved survival and...
Myocarditis and subsequent dilated cardiomyopathy are major causes of heart failure in young adults. humans is highly heterogeneous etiology. Recent studies have indicated that a subgroup myocarditis patients may benefit from immune-targeted therapies, because autoimmunity plays an important role as well contributing to the progression failure. Suppressor cytokine signaling (SOCS) 1 key negative regulation both TLR- receptor-mediated signaling, which involved innate immunity adaptive...
A 70-year-old man with esophageal cancer undergoing nivolumab treatment presented to our hospital suspected myocarditis associated immune checkpoint inhibitor (ICI) therapy. The initial echocardiographic assessment upon admission demonstrated a preserved left ventricular (LV) ejection fraction but impaired right (RV) function. An endomyocardial biopsy revealed significant lymphocytic infiltration and myocyte necrosis. High-dose steroid therapy was initiated on the day of admission. However,...
Background Both endocardial trigger elimination and epicardial substrate modification are effective in treating ventricular fibrillation (VF) Brugada syndrome. However, the primary approach characteristics of patients who respond to ablation remain unknown. Methods Among 123 symptomatic syndrome (VF, 63%; syncope, 37%), was performed 21 VF/electrical storm patients, majority whom were resistant antiarrhythmic drugs. Results Careful mapping revealed that 81% had no specific findings, whereas...
Background There is growing evidence indicating a close relationship between inflammation and atrial fibrillation (AF). Although underlying inflammatory cardiomyopathy may contribute to the development of AF, arrhythmogenic remodeling caused by has not been elucidated in detail. Herein, we examined electrical, structural, autonomic changes atria mouse model autoimmune myocarditis. Methods BALB/c mice were immunized with cardiac myosin peptide (MyHC-α 614–629 ) conjugated complete Freund’s...