A5089062848- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Obstructive Sleep Apnea Research
- Heart Rate Variability and Autonomic Control
- Respiratory Support and Mechanisms
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiovascular and exercise physiology
- Infective Endocarditis Diagnosis and Management
- Hemodynamic Monitoring and Therapy
- Venous Thromboembolism Diagnosis and Management
- ECG Monitoring and Analysis
- Acute Ischemic Stroke Management
- Cardiovascular and Diving-Related Complications
- Autophagy in Disease and Therapy
- Neuroscience of respiration and sleep
- Cardiac Structural Anomalies and Repair
- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Mechanical Circulatory Support Devices
- Advanced MRI Techniques and Applications
- Growth Hormone and Insulin-like Growth Factors
Matsumoto City Hospital
2019-2024
Hanwa Memorial Hospital
2016-2024
Miyagi Prefectural Hospital Organization
2021-2024
Okayama University
1963-2023
Tohoku University
2021
Akita University Hospital
2018
Iwate University
2018
Akita University
2008-2017
Tachikawa Hospital
2013-2015
Eiju General Hospital
2011
Background: Sleep-disordered breathing (SDB) is thought to be a state of inflammation caused by hypoxic stress. Whether adaptive servo ventilation (ASV) attenuates the inflammatory response and improves cardiac function patients with congestive heart failure (CHF) accompanied SDB was not been investigated. Methods Results: Seventeen inpatients New York Heart Association (NYHA) II or III underwent polysomnography. There positive correlation between apnea hypopnea index high-sensitivity...
This study tested the hypothesis that adaptive servo-ventilation (ASV) therapy improves prognosis of heart failure (HF) patients, regardless severity sleep-disordered breathing (SDB).88 consecutive patients were divided into 4 groups based on ASV and SDB severity. The incidence HF, brain natriuretic peptide (BNP) levels, left ventricular ejection fraction (LVEF) followed for 12 months. Fewer HF events, together with an increase in LVEF a decrease BNP, occurred ASV-treated both non-to-mild...
Excessive sympathetic nervous activity may contribute to atrial fibrillation (AF) recurrences after ablation, but its precise role remains controversial. The goals of this study were assess the effects AF on iodine-123-metaiodobenzylguanidine ((123) I-MIBG) findings and elucidate impact procedural outcome in patients undergoing a first-time catheter ablation treat AF.This included 88 consecutive with paroxysmal (n = 48) or persistent 40) who underwent radiofrequency (123) I-MIBG...
TOL plasmid in Pseudomonas putida mt-2 has a series of genes for the degradation xylene, toluene, and their derivatives to pyruvate acetaldehyde (or propionaldehyde). Two operons, i.e., upper operon meta operon, play indispensable roles digestion xylene derivatives: When XyIR protein recognizes derivatives, another controlling gene, xyIS, is activated, which results activation operon. Therefore, we have constructed fusion gene between firefly luciferase under control promoter xyIS gene; by...
ABSTRACT Five strains of an unknown, multidrug-resistant coryneform, gram-positive rod were isolated from blood, bronchial aspirate, and abscess specimens. Four the five highly resistant to antimicrobial agents, including β-lactams, aminoglycosides, macrolides, quinolones, tetracyclines, except for glycopeptides. In immunocompromised patients, bacteremia associated with this organism was rapidly fatal. This coryneform bacterium nonmotile, lipophilic, nonsaccharolytic. Lack pyrazinamidase...
The causal relationship between intracellular Ca2+ overloading and reperfusion-induced contracture was examined from changes in concentration ([Ca2+]i) at rest, the magnitude time course of transients, development contracture. Single myocytes isolated guinea pig hearts were subjected to conditions mimicking ischemia reperfusion. Ischemic condition produced by superfusing with hypoxic substrate-free solutions containing elevated concentrations K+, H+, lactate as described Ferrier et al....
Background: The aim of this study was to investigate whether short-duration adaptive servo-ventilation (ASV) therapy improves cardiac function in heart failure (HF) patients. Methods and Results: Consecutive HF patients (n=86) were divided into 3 groups: group A, ASV for a mean ≥4h; B, ≥1 <4h per day; C, no or <1h. frequency use did not significantly differ between groups A (79.3±19.2%) B (70.9±17.4%). After 6 months, significant increase left ventricular ejection fraction (LVEF), decrease...
Abstract Background Statins are frequently administered to reduce low-density lipoprotein cholesterol (LDL-C) and vascular inflammation, because LDL-C high sensitive C-reactive protein (hs-CRP) associated with risk for cardiovascular events. When statins do not desired levels in high-risk patients coronary artery disease (CAD), ezetimibe can be added or the statin dose increased. However, which strategy is more effective treating CAD has been established. The present study compares...
Immunoelectron microscopy using a colloidal gold-antibody method with anti-rat GH serum demonstrated three morphologically different types of cells in the rat anterior pituitary. They were distinguished as Types I, II and III cells, containing only large secretory granules about 350nm diameter, mixed small granules, 150nm respectively. Double gold labeling particles for PRL or ACTH indicated that neither nor contained same cell.In adult male rats, Type I (68%) predominated over (22%), while...
Background Atrial arrhythmia is often encountered in chronic pulmonary disease with hypertension (PH), but few studies have investigated the electrical remodeling of atrial Ca2+ channels under PH. Methods and Results Wistar rats were injected monocrotaline (MCT), resulting PH right ventricular hypertrophy. The L-type channel current density was significantly decreased cells MCT-treated rats, accompanied by a significant reduction mRNA expression CaV1.2 (α1C) subunit accessory β2 subunit....
We devised a percutaneous coronary intervention (PCI) scoring system based on angiographic lesion complexity and assessed its association with in-hospital complications.Although PCI is finding increasing application in patients artery disease, can lead to complications.Data from 3692 were scored complexity, defined by bifurcation, chronic total occlusion, type C, left main lesion, along acute thrombus the presence of ST-segment elevation myocardial infarction (1 point assigned for each...
The involvement of autophagy in heart disease has been reported. Transgenic mice expressing GFP-LC3 have a useful tool detecting autophagosomes systemically. It is difficult to differentiate increased formation from decreased clearance the using mice.We generated transgenic mCherry-LC3 under alphaMyHC promoter and crossed with GFP-LC3. deference resistance acidic conditions between GFP mCherry overcame limitation.This method an innovative approach examine role analyze autophagosome...
Relationships between myocardial scintigraphic parameters and renal function have not been fully determined. We investigated correlations estimated glomerular filtration rate (eGFR) left ventricular (LV) diastolic using stress electrocardiographic (ECG)-gated single photon emission computed tomography (SPECT).We enrolled 136 consecutive patients with suspected coronary artery disease (CAD) who were assessed technetium-99m ECG-gated SPECT. evaluated SPECT images 17-segment defect scores...
Background Endothelial dysfunction is closely related to cardiovascular events. Several studies have documented that angiotensin II type 1 receptor blockers (ARB) improve peripheral endothelial dysfunction. However, the effect of ARB on coronary function remains elusive. The purpose this study was ascertain beneficial effects human artery function. Methods and Results Twenty-seven patients were randomly assigned either candesartan group (n=14) or control (n=13) followed for 12 months....