A5062071511- Atrial Fibrillation Management and Outcomes
- Cardiovascular Effects of Exercise
- Cancer Immunotherapy and Biomarkers
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- CAR-T cell therapy research
- Congenital heart defects research
- Signaling Pathways in Disease
- Genetic Associations and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Cardiac Fibrosis and Remodeling
- Atherosclerosis and Cardiovascular Diseases
- Inflammatory Myopathies and Dermatomyositis
- interferon and immune responses
- Ion channel regulation and function
- CRISPR and Genetic Engineering
- RNA regulation and disease
- RNA Research and Splicing
- Influenza Virus Research Studies
- Receptor Mechanisms and Signaling
- Peptidase Inhibition and Analysis
- Connexins and lens biology
- Phytochemical and Pharmacological Studies
- Hippo pathway signaling and YAP/TAZ
- Multiple Myeloma Research and Treatments
University of Tsukuba
2020-2024
National Institute of Infectious Diseases
2024
National Institute of Biomedical Innovation, Health and Nutrition
2019-2020
Mie University
2014-2019
Direct cardiac reprogramming holds great potential for regenerative medicine. However, it remains inefficient, and induced cardiomyocytes (iCMs) generated in vitro are less mature than those vivo, suggesting that undefined extrinsic factors may regulate reprogramming. Previous studies mainly used hard polystyrene dishes, yet the effect of substrate rigidity on unclear. Thus, we developed a Matrigel-based hydrogel culture system to determine roles matrix stiffness mechanotransduction We found...
Background There is growing evidence indicating a close relationship between inflammation and atrial fibrillation (AF). Although underlying inflammatory cardiomyopathy may contribute to the development of AF, arrhythmogenic remodeling caused by has not been elucidated in detail. Herein, we examined electrical, structural, autonomic changes atria mouse model autoimmune myocarditis. Methods BALB/c mice were immunized with cardiac myosin peptide (MyHC-α 614–629 ) conjugated complete Freund’s...
The aim of the present study was to clarify age‑related changes in 13 clinical parameters and their associations with common complex diseases. Study subjects comprised 6,027 community‑dwelling individuals who were recruited a population‑based longitudinal genetic epidemiological study. Bonferroni's correction applied compensate for multiple comparisons association P<0.0011 considered statistically significant. Body mass index waist circumference increased age up ~50 years decreased...
Oxidative stress could be a possible mechanism and therapeutic target of atrial fibrillation (AF). However, the effects xanthine oxidase (XO) inhibition for AF remain to fully elucidated. We investigated novel XO inhibitor febuxostat on compared with allopurinol in hypertension rat model. Five-week-old Dahl salt-sensitive rats were fed either low-salt (LS) (0.3% NaCl) or high-salt (HS) (8% diet. After 4 weeks diet, HS diet divided into three groups: orally administered vehicle (HS-C), (5...
The C→T polymorphism (rs6929846) of the butyrophilin, subfamily 2, member A1 (BTN2A1) gene has been previously identified as a susceptibility locus for myocardial infarction by genome-wide association study. As hypertension is major risk factor infarction, between BTN2A1 polymorphism, rs6929846, and may be partly due to its effect on susceptibility. aim present study was examine possible rs6929846 with hypertension. subjects comprised 5,959 community-dwelling individuals (2,183 3,776...
Inherited arrhythmia syndromes (IASs) can cause life-threatening arrhythmias and are responsible for a significant proportion of sudden cardiac deaths (SCDs). Despite progress in the development devices to prevent SCDs, precise molecular mechanisms that induce detrimental remain be fully investigated, more effective therapies desirable. In present study, we screened large-scale randomly mutagenized mouse library by electrocardiography establish disease model IASs consequently found one...
Abstract Hypertrophic cardiomyopathy (HCM) is an inherited disorder characterized by left ventricular hypertrophy and diastolic dysfunction, increases the risk of arrhythmias heart failure. Some patients with HCM develop a dilated phase hypertrophic (D-HCM) have poor prognosis; however, its pathogenesis unclear few pathological models exist. This study established disease-specific human induced pluripotent stem cells (iPSCs) from patient D-HCM harboring mutation in MYBPC3 (c.1377delC),...
Abstract Isorhamnetin, a natural flavonoid, has strong antioxidant and antifibrotic effects, regulatory effect against Ca2+-handling. Atrial remodeling due to fibrosis abnormal intracellular Ca2+ activities contributes initiation persistence of atrial fibrillation (AF). The present study investigated the isorhamnetin on angiotensin II (AngII)-induced AF in mice. Wild-type male mice (C57BL/6J, 8 weeks old) were assigned three groups: (1) control group, (2) AngII-treated (3) AngII-...
Recently, the efficacy of Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccination is being reassessed in accordance with achievements clinical tuberculosis (TB) vaccine research. However, mechanisms ultimately determining success or failure BCG to prevent pulmonary TB remain poorly understood. In this study, we analyzed protective effects intradermal by using specific pathogen-free cynomolgus macaques Asian origin that were intradermally vaccinated (Tokyo strain) followed (Erdman...
Abstract The analysis of age-related immune senescent is extremely meaningful to understand the vital homeostasis in individuals among aging society. Influenza virus (FluV) infection a major public health concern due its high infectivity and ability severe respiratory illness elderly people. reduced responses after Flu vaccination humans are recognized also lifestyle diseases such as diabetes mellitus (DM). Understanding hypofunction necessary optimize resume comprehensive that will provide...
Abstract The analysis of age-related immune senescent is extremely meaningful to understand the vital homeostasis in individuals among aging society. Epstein-Barr virus (EBV) establishes latent infection &gt;90% adults worldwide. In general, chronically infected EBV controlled well for a lifelong healthy adults. Since, reactivated by failure host system, it can be an index hypofunction. A non-human-primate, experimental animal, cynomolgus macaque (CM) has long life span and used...
Background and Purpose: Isorhamnetin, a natural flavonoid, has strong antioxidant anti-fibrotic effects, regulatory effect against Ca2+-handling. Atrial remodeling due to fibrosis abnormal intracellular Ca2+ activities contributes initiation persistence of atrial fibrillation (AF). This study investigated the isorhamnetin on angiotensin II (AngII)-induced AF in mice. Experimental Approach: Wild-type male mice (C57BL/6J, 8 weeks old) were assigned three groups: (1) control group, (2)...