A5069936977- Hepatitis B Virus Studies
- Primate Behavior and Ecology
- Hepatitis C virus research
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Amphibian and Reptile Biology
- RNA modifications and cancer
- HIV Research and Treatment
- Malaria Research and Control
- Immune responses and vaccinations
- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- Tuberculosis Research and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Bird parasitology and diseases
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Viral Infections and Vectors
- Eicosanoids and Hypertension Pharmacology
- Immune Response and Inflammation
National Institute of Biomedical Innovation, Health and Nutrition
2017-2020
Metabolites of eicosapentaenoic acid exert various physiologic actions. 17,18-Epoxyeicosatetraenoic (17,18-EpETE) is a recently identified new class antiallergic and anti-inflammatory lipid metabolite acid, but its effects on skin inflammation the underlying mechanisms remain to be investigated.We evaluated effectiveness 17,18-EpETE for control contact hypersensitivity in mice cynomolgus macaques. We further sought reveal by identifying responsible receptor cellular target...
Avian-origin influenza viruses like H5N1 and H7N9 often cause severe symptoms with high mortality in humans. Animal models are useful for clarification of the mechanisms pathogenicity these infections. In this study, to expand potential utility Northern tree shrew (Tupaia belangeri) virus infection, we assessed avian tupaia. Infectious was detected continuously from nasal, oral, tracheal, conjunctival swab samples animals infected viruses. infection tupaia caused diffuse pneumonia fever...
Abstract The northern tree shrew ( Tupaia belangeri ) possesses high potential as an animal model of human diseases and biology, given its genetic similarity to primates. Although information on the has already been published, some entire coding sequences (CDSs) genes remained incomplete, reliability these CDSs difficult determine. To improve determination CDSs, we performed sequencing whole-genome, mRNA, total RNA integrated resulting data. Additionally, established criteria for selection...
To date, the chimpanzee has been used as natural infection model for hepatitis B virus (HBV). However, this is very costly and difficult to use because of ethical animal welfare issues, we aimed establish tupaia (Tupaia belangeri) a new HBV characterized its intrahepatic innate immune response upon infection. First, compared propagation genotypes A2 C in vivo hepatocytes. At 8-10days post (dpi), level HBV-A2 liver was found be higher than that HBV-C. Abnormal architecture cell cords mitotic...
Hepatitis B virus (HBV) infection causes acute and chronic hepatitis, which is a major public health concern worldwide. Immunization methods incorporating hepatitis surface-small (HBs-S) antigen core (HBc) have been proposed as candidate therapeutic vaccines, but the elimination of existing HBV remains challenge. To enhance efficacy HBs HBc vaccination, we investigated HBs-large (HBs-L) an immunogen, carboxyl vinyl polymer (CVP) excipient. HBs-S or HBs-L, in combination with antigen, was...
In the present study, we demonstrate that Japanese macaque (Macaca fuscata) can be used as an effective alternative in vivo model for investigating hypnozoite-induced relapsing infection caused by Plasmodium cynomolgi B strain, and this is comparable to rhesus model. Two female macaques (JM-1 JM-2; aged 5 years; weighing about 4.0 kg) were experiment. To produce sporozoites mosquitoes, blood infected with P. strain was collected from donor monkey JM-1 fed approximately 200 mosquitoes using...
Recently, the efficacy of Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccination is being reassessed in accordance with achievements clinical tuberculosis (TB) vaccine research. However, mechanisms ultimately determining success or failure BCG to prevent pulmonary TB remain poorly understood. In this study, we analyzed protective effects intradermal by using specific pathogen-free cynomolgus macaques Asian origin that were intradermally vaccinated (Tokyo strain) followed (Erdman...