Vlad G. Zaha
A5019736800- Cardiovascular Function and Risk Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Advanced NMR Techniques and Applications
- Electron Spin Resonance Studies
- Metabolism, Diabetes, and Cancer
- Cardiac Ischemia and Reperfusion
- Cardiac tumors and thrombi
- Cardiomyopathy and Myosin Studies
- High Altitude and Hypoxia
- Pancreatic function and diabetes
- Atomic and Subatomic Physics Research
- Cardiac electrophysiology and arrhythmias
- Cancer Treatment and Pharmacology
- Cardiovascular Effects of Exercise
- Cardiovascular and exercise physiology
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Structural Anomalies and Repair
The University of Texas Southwestern Medical Center
2017-2025
Southwestern Medical Center
2017-2025
The University of Texas at Arlington
2025
Advanced Imaging Research (United States)
2017-2024
Harold C. Simmons Comprehensive Cancer Center
2020-2024
American Heart Association
2024
Virginia Commonwealth University
2024
Parkland Health & Hospital System
2020-2022
Vanderbilt University Medical Center
2022
Institute for Exercise and Environmental Medicine
2021
In obesity and diabetes, myocardial fatty acid utilization oxygen consumption (MVo(2)) are increased, cardiac efficiency is reduced. Mitochondrial uncoupling has been proposed to contribute these metabolic abnormalities but not directly demonstrated.Oxygen function were determined in db/db hearts perfused with glucose or palmitate. was saponin-permeabilized fibers proton leak kinetics H(2)O(2) generation isolated mitochondria.db/db exhibited reduced increased MVo(2). reactive species (ROS)...
Background— Diabetes-associated cardiac dysfunction is associated with mitochondrial and oxidative stress, which may contribute to left ventricular dysfunction. The contribution of altered myocardial insulin action, independent changes in systemic metabolism, incompletely understood. present study tested the hypothesis that perinatal loss signaling heart impairs function. Methods Results— In 8-week-old mice cardiomyocyte deletion receptors (CIRKO), inotropic reserves were reduced,...
Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart and one for which no efficacious therapies exist. Obesity lipid mishandling greatly contribute to HFpEF. However, molecular mechanism(s) governing metabolic alterations perturbations in homeostasis HFpEF are largely unknown. Here, we report that cardiomyocyte steatosis coupled increases activity transcription factor FoxO1 (Forkhead box protein O1). depletion, as well over-expression Xbp1s (spliced...
Immune checkpoint inhibitors (ICIs) are approved for multiple cancers but can result in ICI-associated myocarditis, an infrequent life-threatening condition. Elevations cardiac biomarkers, specifically troponin-I (cTnI), troponin-T (cTnT), and creatine kinase (CK), used diagnosis. However, the association between temporal elevations of these biomarkers with disease trajectory outcomes has not been established.
The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1beta (PGC-1beta) has been implicated in important metabolic processes. A mouse lacking PGC-1beta (PGC1betaKO) was generated and phenotyped using physiological, molecular, bioinformatic approaches. PGC1betaKO mice are generally viable metabolically healthy. Using systems biology, we identified a general defect the expression of genes involved mitochondrial function and, specifically, electron...
Fatty acid-induced mitochondrial uncoupling and oxidative stress have been proposed to reduce cardiac efficiency contribute dysfunction in type 2 diabetes. We hypothesized that may also reduced contractile the 1 diabetic Akita mouse model (Akita).Cardiac function substrate utilization were determined isolated working hearts vivo by echocardiography. Mitochondrial coupling saponin-permeabilized fibers, proton leak kinetics was mitochondria. Hydrogen peroxide production aconitase activity...
Rationale: Pressure overload cardiac hypertrophy, a risk factor for heart failure, is associated with reduced mitochondrial fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS) proteins that correlate in rodents PGC-1α expression. Objective: To determine the role of PGC-1β maintaining energy metabolism contractile function pressure hypertrophy. Methods Results: deficient (KO) mice wildtype (WT) controls were subjected to transverse aortic constriction (TAC). Although LV was...
Various cardioprotective approaches have been evaluated to prevent chemotherapy-related cardiotoxicity; however, their overall utility remains uncertain.To assess the effects of neurohormonal therapies in preventing cardiotoxicity patients receiving chemotherapy.This meta-analysis included randomized clinical trials adult that underwent chemotherapy and (beta-blockers, mineralocorticoid receptor antagonists, or ACE inhibitors/ARBs) vs. placebo with follow-up ≥4 weeks. The primary outcome was...
The NCCN Guidelines for the Management of Immunotherapy-Related Toxicities are intended to provide oncology practitioners with guidance on how manage wide-ranging and potentially fatal toxicities that may occur cancer immunotherapy. guidelines address immune-related adverse events related immune checkpoint inhibitors, CAR T-cell therapies, lymphocyte engagers (which include T-cell–engaging bispecific antibodies). These Insights highlight recent guideline updates pertaining management emerging
Hematopoietic stem cell transplantation can cure various disorders but poses cardiovascular risks, especially for elderly patients and those with diseases. Cardiovascular evaluations are crucial in pretransplantation assessments, guidelines lacking. This American Heart Association scientific statement summarizes the data on transplantation-related complications provides guidance management throughout transplantation. consists of 4 phases: workup, conditioning therapy infusion, immediate...
Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, but ICI myocarditis (ICI-M) remains a potentially fatal complication. The clinical implications and predictors of left ventricular ejection fraction (LVEF) <50% in ICI-M are not well understood. aim this study was to identify factors associated with LVEF vs ≥50% at the time hospitalization for ICI-M. A secondary objective evaluate relationship between 30-day all-cause mortality. International ICI-Myocarditis Registry,...