A5101477428- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Advanced MRI Techniques and Applications
- Prostate Cancer Treatment and Research
- Orthopaedic implants and arthroplasty
- Cardiovascular Function and Risk Factors
- Amyloidosis: Diagnosis, Treatment, Outcomes
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Total Knee Arthroplasty Outcomes
- Parathyroid Disorders and Treatments
- Orthopedic Infections and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- MRI in cancer diagnosis
- Prostate Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Peptidase Inhibition and Analysis
- Advanced Biosensing Techniques and Applications
- Advanced Radiotherapy Techniques
- Cardiomyopathy and Myosin Studies
- Lanthanide and Transition Metal Complexes
- Cancer, Hypoxia, and Metabolism
- Radiation Dose and Imaging
Uppsala University
2016-2025
Odense University Hospital
2025
Aarhus University
2017-2024
Aarhus University Hospital
2014-2024
Uppsala University Hospital
2013-2024
Länssjukhuset i Kalmar
2007
The expression status of human epidermal growth factor receptor type 2 (HER2) predicts the response HER2-targeted therapy in breast cancer. ABY-025 is a small reengineered Affibody molecule targeting unique epitope HER2 receptor, not occupied by current therapeutic agents. This study evaluated distribution, safety, dosimetry, and efficacy <sup>111</sup>In-ABY-025 for determining metastatic <b>Methods:</b> Seven patients with cancer HER2-positive (<i>n</i> = 5) or -negative 2) primary tumors...
Anti-1-amino-3-<sup>18</sup>F-fluorocyclobutane-1-carboxylic acid (<sup>18</sup>F-FACBC) is a synthetic amino analog PET radiotracer undergoing clinical trials for the evaluation of prostate and other cancers. We aimed to describe common physiologic uptake patterns, incidental findings, variants in patients who had undergone <sup>18</sup>F-FACBC PET. <b>Methods:</b> Sixteen involving 611 studies from 6 centers, which included dosimetry on 12 healthy volunteers, were reviewed. Qualitative...
<sup>68</sup>Ga-DOTATOC and <sup>68</sup>Ga-DOTATATE are 2 radiolabeled somatostatin analogs for in vivo diagnosis of neuroendocrine tumors with PET. The aim the present work was to measure their comparative biodistribution radiation dosimetry. <b>Methods:</b> Ten patients diagnosed were included. Each patient underwent a 45-min dynamic 3 whole-body PET/CT scans at 1, 2, h after injection each tracer on consecutive days. Absorbed doses calculated using OLINDA/EXM 1.1. <b>Results:</b> Data...
<sup>68</sup>Ga-ABY-025 is a radiolabeled Affibody molecule for in vivo diagnosis of human epidermal growth factor receptor 2 (HER2)–positive breast cancer tumors with PET. The aim the present work was to measure biodistribution and estimate radiation dosimetry different peptide mass doses single group patients using dynamic serial whole-body PET/CT. <b>Methods:</b> Eight metastatic were included. Each patient underwent an abdominal 45-min 3 PET/CT scans at 1, 2, 4 h after injection low dose...
DPD scintigraphy has been advocated for imaging cardiac amyloid in ATTR amyloidosis. PET utilizing 11C-Pittsburgh compound B (PIB) is the gold standard brain Alzheimer’s disease. PIB was recently shown to identify amyloidosis both AL and In population, two types of fibrils exist, one containing fragmented full-length TTR (type A) other only B). The aim this study further evaluate PIB-PET patients with hereditary Ten biopsy-proven V30M discrete or no signs involvement were included. Patients...
Abstract Aims Left ventricular (LV) myocardial work index (LVMWI) derived from pressure–strain analysis resembles a novel non-invasive method for LV function evaluation. global longitudinal strain (LVGLS) has proven beneficial risk stratification in cardiac amyloidosis (CA) patients. This study aimed to evaluate the potential additive value of LVMWI outcome prediction CA Methods and results We enrolled 100 patients period 2014–19 Aarhus University Hospital, Denmark Uppsala Sweden. All...
The resolution and quantitative accuracy of PET are highly influenced by the reconstruction method. Penalized-likelihood estimation algorithms allow for fully convergent iterative reconstruction, generating a higher image contrast than ordered-subsets expectation maximization (OSEM) while limiting noise. In this study, type penalized known as block-sequential regularized (BSREM) was compared with time-of-flight OSEM (TOF OSEM). Various strengths noise penalization factor β were tested along...
The gastrin-releasing peptide receptor (GRPR/BB2) is a molecular target for the visualization of prostate cancer. This work focused on development high-affinity, hydrophilic, antagonistic, bombesin-based imaging agents PET and SPECT. bombesin antagonist analog d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 ([d-Phe6,Sta13,Leu14]bombesin[6–14]) was synthesized conjugated to 1,4,7-triazacyclononane-N,N′,N″-triacetic acid (NOTA) via diethylene glycol (PEG2) linker. resulting conjugate,...
The overexpression of gastrin-releasing peptide receptor (GRPR) in cancer can be used for peptide-receptor mediated radionuclide imaging and therapy. We have previously shown that an antagonist analog bombesin RM26 conjugated to 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) via a diethyleneglycol (PEG2) spacer (NOTA-PEG2-RM26) labeled with 68Ga GRPR-expressing tumors. In this study, we evaluated if variation mini-PEG length optimization targeting properties the NOTA-conjugated RM26....
Radionuclide molecular imaging of human epidermal growth factor receptor type 2 (HER2) expression may help to stratify breast and gastroesophageal cancer patients for HER2-targeting therapies. Albumin-binding domain-derived affinity proteins (ADAPTs) are a new small (46-59 amino acids) protein useful as probes imaging. The aim this first-in-humans study was evaluate the biodistribution, dosimetry, safety HER2-specific 99mTc-ADAPT6. Methods: Twenty-nine with primary were included. In 22...
Radionuclide molecular imaging of human epidermal growth factor type 2 (HER2) expression may enable a non-invasive discrimination between HER2-positive and HER2-negative breast cancers for stratification patients HER2-targeted treatments. DARPin G3 is small (molecular weigh 14 kDa) scaffold protein with picomolar affinity to HER2. The aim this first-in-human study was evaluate the safety, biodistribution dosimetry <sup>99m</sup>Tc-(HE)<sub>3</sub>-G3. <b>Methods:</b> Three cohorts primary...
The gastrin-releasing peptide receptor (GRPR) is overexpressed in prostate cancer (PCa) and hormone-driven breast (BCa). aim of this phase I clinical trial was to evaluate safety, biodistribution, dosimetry after the administration recently developed GRPR-targeting antagonistic bombesin analogue [99mTc]Tc-maSSS-PEG2-RM26 PCa BCa patients. Planar whole-body SPECT/CT imaging performed six patients seven 2, 4, 6, 24 h post intravenous 40 µg (600-700 MBq). No adverse events or pathological...
[15O]H2O PET/CT allows noninvasive quantification of tissue perfusion and can potentially play a future role in the diagnosis treatment peripheral artery disease. We aimed to evaluate reliability dynamic PET imaging for measuring lower extremity skeletal muscle perfusion. Ten healthy participants underwent same-day test-retest study with six scans legs feet. Manual volume-of-interests were drawn muscles, time activity curves extracted. K1 values (mL/min/100 mL) estimated using single-tissue...
Because a correlation between tau pathology and the clinical symptoms of Alzheimer disease (AD) has been hypothesized, there is increasing interest in developing PET tracers that bind specifically to protein. The aim this study was evaluate tracer kinetic models for quantitative analysis generation parametric images novel ligand (<i>S</i>)-<sup>18</sup>F-THK5117. <b>Methods:</b> Nine subjects (5 with AD, 4 mild cognitive impairment) received 90-min dynamic...
In phase I/II-studies radiolabelled ABY-025 Affibody molecules identified human epidermal growth factor receptor 2 (HER2) expression in breast cancer metastases using PET and SPECT imaging. Here, we wanted to investigate the utility of a simple intra-image normalization tumour-to-reference tissue-ratio (T/R) as HER2 status discrimination strategy overcome potential issues related cross-calibration scanning devices.Twenty-three women with pre-diagnosed HER2-positive/negative metastasized were...
Abstract Background In a Phase I study treatment with the serum amyloid P component (SAP) depleter miridesap followed by monoclonal antibody to SAP (dezamizumab) showed removal of from liver, spleen and kidney in patients systemic amyloidosis. We report results 2 concurrent immuno-positron emission tomography (PET) assessing efficacy, pharmacodynamics, pharmacokinetics, safety cardiac uptake (of dezamizumab) following same intervention Methods Both were uncontrolled open-label studies. After...
Differences in tracer characteristics may influence the interpretation of PET MPI. We compare reading MPIs with a low-extraction retention (82Rb) and high-extraction non-retention (15O-water) selected cohort patients known CAD. Thirty-nine CAD referred to 82Rb MPI due angina underwent rest stress imaging both tracers experienced readers provided blinded consensus reads all studies. In addition, comparison regional global quantitative measures perfusion was performed. The results showed 74%...
Expression of the gastrin-releasing peptide receptor (GRPR) in prostate cancer suggests that this can be used as a potential molecular target to visualize and treat these tumors. We have previously investigated an antagonist analog bombesin (D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2, RM26) conjugated 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) via diethylene glycol (PEG2) spacer (NOTA-P2-RM26) labeled with 68Ga 111In. found conjugate has favorable properties for vivo imaging...
Implant loosening is the most common indication for revision surgery after total hip arthroplasty (THA). Although bone resorption around implants plays a pivotal role in pathophysiology of loosening, it unknown whether potent early inhibition osteoclasts could mitigate this process and thus reduce need surgery. We performed randomized, double-blind, placebo-controlled phase 2 trial 64 patients aged 35 to 65 years with unilateral osteoarthritis hip. They underwent an uncemented THA were...
5 patients were revised with impaction of morselized frozen allograft and a cemented total hip arthroplasty (THA) because loosening osteolysis primary arthroplasty. Plain film radiographs the stems showed stable implants in all 15-24 months after surgery. The clinical results good. We used: 1) Positron Emission Tomography (PET) to evaluate vascularization new bone formation allograft, 2) kinetic [18F]-fluoride PET produce quantitative images, interpreted as surrounding femur stem, 3)...