A5075487446- Radiopharmaceutical Chemistry and Applications
- Neuroendocrine Tumor Research Advances
- Medical Imaging Techniques and Applications
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Metabolism, Diabetes, and Cancer
- Lung Cancer Treatments and Mutations
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Chemical Reactions and Isotopes
- Cell Adhesion Molecules Research
- Muon and positron interactions and applications
- Prostate Cancer Treatment and Research
- HER2/EGFR in Cancer Research
- S100 Proteins and Annexins
- Radiomics and Machine Learning in Medical Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Glycosylation and Glycoproteins Research
- Medical Imaging and Pathology Studies
- DNA and Nucleic Acid Chemistry
- Mass Spectrometry Techniques and Applications
Uppsala University
2015-2024
Science for Life Laboratory
2020-2024
Uppsala University Hospital
2012-2022
Academy of Athens
2011
Purpose: Positron Emission Tomography (PET) imaging of HER2 expression could potentially be used to select patients for HER2-targed therapy, predict response based on uptake and monitoring.In this phase I/II study the HER2-binding Affibody molecule ABY-025 was labeled with 68 Ga-gallium ([ Ga]ABY-025) PET effect peptide mass, test-retest variability correlation quantified in tumors histopathology.Experimental design: Sixteen women known metastatic breast cancer on-going treatment were...
Unimolecular triple incretins, combining the activity of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCG), have demonstrated reduction in body weight improved glucose control rodent models. We developed SAR441255, a synthetic peptide agonist GLP-1, GCG, GIP receptors, structurally based on exendin-4 sequence. SAR441255 displays high potency with balanced activation all three target receptors. In animal models, metabolic outcomes were...
A straightforward labeling using generator produced positron emitting (68)Ga, which provides high quality images, may result in kit type production of PET radiopharmaceuticals and make examinations possible also at centers lacking accelerators. The introduction macrocyclic bifunctional chelators that would provide fast (68)Ga-complexation room temperature simplify even further tracer preparation open wide possibilities for (68)Ga-labeling fragile potent macromolecules. Gallium-68 has the...
Quantitative imaging and dosimetry are crucial for individualized treatment during peptide receptor radionuclide therapy (PRRT). <sup>177</sup>Lu-DOTATATE <sup>68</sup>Ga-DOTATOC/<sup>68</sup>Ga-DOTATATE used, respectively, PRRT PET examinations targeting somatostatin receptors (SSTRs) in patients affected by neuroendocrine tumors. The aim of the study was to quantitatively qualitatively compare performance <sup>68</sup>Ga-DOTATOC <sup>68</sup>Ga-DOTATATE context subsequent with under...
<sup>68</sup>Ga-DOTATOC and <sup>68</sup>Ga-DOTATATE are 2 radiolabeled somatostatin analogs for in vivo diagnosis of neuroendocrine tumors with PET. The aim the present work was to measure their comparative biodistribution radiation dosimetry. <b>Methods:</b> Ten patients diagnosed were included. Each patient underwent a 45-min dynamic 3 whole-body PET/CT scans at 1, 2, h after injection each tracer on consecutive days. Absorbed doses calculated using OLINDA/EXM 1.1. <b>Results:</b> Data...
<sup>68</sup>Ga-ABY-025 is a radiolabeled Affibody molecule for in vivo diagnosis of human epidermal growth factor receptor 2 (HER2)–positive breast cancer tumors with PET. The aim the present work was to measure biodistribution and estimate radiation dosimetry different peptide mass doses single group patients using dynamic serial whole-body PET/CT. <b>Methods:</b> Eight metastatic were included. Each patient underwent an abdominal 45-min 3 PET/CT scans at 1, 2, 4 h after injection low dose...
The glucagonlike peptide 1 receptor (GLP-1R) is mainly expressed on β-cells in the islets of Langerhans and therefore an attractive target for imaging β-cell mass. In present study, <sup>68</sup>Ga-labeled exendin-4 was evaluated PET quantification GLP-1R pancreas. <b>Methods:</b> Dose escalation studies 1,4,7-tris(carboxymethylaza)cyclododecane-10-azaacetyl (DO3A)-exendin-4 were performed rats (organ distribution) cynomolgus monkeys (PET/CT imaging) to determine GLP-1R–specific tissue...
This theme issue presents current achievements in the development of radioactive agents, pre-clinical and clinical molecular imaging, radiotherapy context theranostics field oncology.
Abstract Unimolecular dual agonists for the glucagon-like peptide 1 receptor (GLP1R) and glucagon (GCGR) are emerging as a potential new class of important therapeutics in type 2 diabetes (T2D). Reliable quantitative assessments vivo occupancy on each would improve understanding efficacy this drugs. In study we investigated target agonist SAR425899 at GLP1R pancreas GCGR liver by Positron Emission Tomography/Computed Tomography (PET/CT). Patients with T2D were examined [ 68 Ga]Ga-DO3A-Tuna-2...
68Ga-DOTATOC and 68Ga-DOTATATE are radiolabeled somatostatin analogs used for the diagnosis of receptor-expressing neuroendocrine tumors (NETs), SUV measurements suggested treatment monitoring. However, changes in net influx rate (Ki) may better reflect effects than those SUV, accordingly there is a need to compute parametric images showing Ki at voxel level. The aim this study was evaluate methods computation by comparison volume interest (VOI)-based assess image contrast terms...
PET/CT with <sup>68</sup>Ga-DOTA-somatostatin analogs has been tested for therapy monitoring in patients neuroendocrine tumors (NETs). However, SUVs do not correlate the net influx rate (K<sub>i</sub>), as a representation of somatostatin receptor expression. In this study, tumor-to-blood ratio (TBR) was evaluated an alternative tool semiquantitative assessment <sup>68</sup>Ga-DOTATOC and <sup>68</sup>Ga-DOTATATE tumor uptake NETs. <b>Methods:</b> Twenty-two NET underwent 45-min dynamic scan...