A5073521647- Hydrology and Sediment Transport Processes
- Soil erosion and sediment transport
- Hydrology and Watershed Management Studies
- Hydraulic flow and structures
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Treatments and Studies
- Advanced Proteomics Techniques and Applications
- Groundwater flow and contamination studies
- Tropical and Extratropical Cyclones Research
- Water Quality and Resources Studies
- Concrete and Cement Materials Research
- Fish Ecology and Management Studies
- Flood Risk Assessment and Management
- Lubricants and Their Additives
- Statistical Methods in Clinical Trials
- Mass Spectrometry Techniques and Applications
- Tribology and Lubrication Engineering
- Hepatocellular Carcinoma Treatment and Prognosis
- Metabolomics and Mass Spectrometry Studies
- Gastric Cancer Management and Outcomes
- Irrigation Practices and Water Management
- Geological formations and processes
- African studies and sociopolitical issues
- Water resources management and optimization
- Amyloidosis: Diagnosis, Treatment, Outcomes
Connecticut College
2010-2024
GlaxoSmithKline (United Kingdom)
2017-2022
Age UK
2017-2019
Leeds Teaching Hospitals NHS Trust
2003-2018
Imperial College London
2016
Sentara Norfolk General Hospital
2016
University of Leeds
1991-2015
Sentara Virginia Beach General Hospital
2015
Leeds General Infirmary
2002-2014
St James's University Hospital
2007-2014
Germline BRCA1 mutations confer a substantial lifetime risk of breast and ovarian cancer, but whether cancer at other sites is increased less clear. To evaluate the risks cancers in mutation carriers, we conducted cohort study 11 847 individuals from 699 families segregating that were ascertained 30 centers across Europe North America.The observed incidence was compared with expected based on population rates. Relative (RRs) each type carriers relative to for general estimated by weighting...
Profiling approaches in proteomics, such as surface-enhanced laser desorption/ionization (SELDI) mass spectrometry, are used disease marker discovery. The aim of this study was to investigate the potential influence selected preanalytical factors on results obtained.Plasma samples anticoagulated with EDTA, citrate, or heparin, and serum from healthy volunteers were profiled by SELDI CM10, immobilized metal affinity capture (IMAC) array copper, H50 chip surfaces. Using linear mixed-effects...
SUMMARY IL-6, tumour necrosis factor-α (TNE-α) and IL-1 are thought to be the key mediators of acute phase response although much evidence is based on in vitro studies. It not clear what extent each proteins regulated vivo by these cytokines. The aim this study was examine effects IL-6 treatment eight patients with cancer concentrations an extensive range positive negative proteins. part a larger investigation assess value management chemotherapy-induced thrombocytopenia. administered daily...
The aim of this study was to identify and validate novel predictive and/or prognostic serum proteomic biomarkers in patients with epithelial ovarian cancer (EOC) treated as part the phase III international ICON7 clinical trial.ICON7 a trial EOC which showed modest but statistically significant benefit progression-free survival (PFS) addition bevacizumab standard chemotherapy. Serum samples from 10 who received (five responders five nonresponders) were analyzed by mass spectrometry candidate...
This paper summarizes measurements of velocity along three reaches a small mountain channel with step–pool bedforms. A one-dimensional electromagnetic current meter was used to record fluctuations at 37 fixed measurement points during five intervals spanning the peak annual snowmelt hydrograph. Measurement cross-sections were located upstream from bed-step, step lip, downstream step, and in uniform-gradient run. Data analyses focused on characteristics profiles, correlations between...
In order to characterize variability associated with sampling coarse fluvial sediment, surface grain‐size distributions were characterized at eight sample sites within gravel‐ boulder‐bed channels. Four methods used: (1) a random walk, (2) grid spaced an interval equal the intermediate diameter of largest clast in area, (3) one half method 2, and (4) randomly chosen subsection which patch count most clasts least partially exposed was conducted. At each site, six replicates performed,...
Abstract A field‐based project was initiated in order to characterize velocities and sediment entrainment a forced‐pool riffle sequence. Three‐dimensional turbulence intensities were measured with an acoustic Doppler velocimeter at 222 different points three similar flows that averaged approximately 4·35 m 3 s −1 within large pool–riffle unit on North Saint Vrain Creek, Colorado. Sediment‐sorting patterns observed the introduction of 500 tracer particles painted according initial seeding...
Validated objective biomarkers are needed for patients with renal cell carcinoma (RCC) to guide patient management and define high-risk populations follow-up or therapeutic purposes. Patients undergoing nephrectomy RCC (n=286 all stages, 84% conventional clear type) were included a median duration of 5 years. The prognostic significance pre-operative haematological biochemical variables, including C-reactive protein (CRP) values examined whether they added additional information recently...
Objectively measured circulating biomarkers of prognosis complementing existing clinicopathological models are needed in renal cell carcinoma (RCC). Blood samples collected from 216 RCC patients Leeds before nephrectomy (median follow-up 7 years) were analysed for C-reactive protein (CRP), osteopontin (OPN) and carbonic anhydrase IX (CA9) prognostic significance determined. CA9, OPN CRP univariately overall survival (OS), cancer-specific (CSS) disease-free (DFS) with CA9 being independently...
Abstract Background In a Phase I study treatment with the serum amyloid P component (SAP) depleter miridesap followed by monoclonal antibody to SAP (dezamizumab) showed removal of from liver, spleen and kidney in patients systemic amyloidosis. We report results 2 concurrent immuno-positron emission tomography (PET) assessing efficacy, pharmacodynamics, pharmacokinetics, safety cardiac uptake (of dezamizumab) following same intervention Methods Both were uncontrolled open-label studies. After...
An experimental and computational research approach was used to determine interactions between pool geometry hydraulics. A 20‐m‐long, 1.8‐m‐wide flume investigate the effect of four different geometric aspects shape on flow velocity. Plywood sections were systematically alter constriction width, depth, length, exit‐slope gradient, each at two separate levels. Using resulting 16 unique geometries with measured velocities in four‐way factorial analyses produced an empirical assessment role...
Sediment-sorting processes related to varying channel-bed morphology were investigated from April November 1993 along a 1-km pool-riffle and step-pool reach of North Saint Vrain Creek, small mountain stream in the Rocky Mountains northern Colorado. Measured cross-sectional areas flow used suggest higher velocities pools than riffles at high flow. Three hundred sixteen tracer particles, ranging size 16 mm 256 mm, placed two separate pool-riffle-pool sequences assess sediment-sorting patterns...
Abstract Urinary biomarkers or profiles that allow noninvasive detection of recurrent transitional cell carcinoma (TCC) the bladder are urgently needed. We obtained duplicate proteomic (SELDI) from 227 subjects (118 TCC, 77 healthy controls and 32 with benign urological conditions) used linear mixed effects models to identify peaks differentially expressed between TCC within subgroups. A Random Forest classifier was trained on 130 develop an algorithm predict presence in a randomly selected...
Abstract In the 1930s, after only three years of scientific investigation at University Michigan Institute for Fisheries Research, cheap labor and government-sponsored conservation projects spearheaded by Civilian Conservation Corps allowed widespread adoption in-stream structures throughout United States. From 1940s through 1970s, designs remained essentially unchanged, their use continued. Despite a large investment in construction over these four decades, very few studies were undertaken...
Early identification and prognostic stratification of delayed graft function following renal transplantation has significant potential to improve outcome. Mass spectrometry analysis serum samples, before on day 2 post transplant from five patients with an uncomplicated transplant, identified aminoacylase-1 (ACY-1) as a outcome biomarker. Following assay development, longitudinal samples initial validation cohort 55 confirmed that the ACY-1 level 1 or was moderate predictor function, similar...
A recent trend in health care is to integrate palliative (PC) programs across multiple hospitals reduce variation, improve quality, and cost.The study objective was demonstrate the benefits of PC for a system.The descriptive using retrospective medical records seven federated where developed differently before system integration. Measured were length stay (LOS), mortality, readmissions, saved intensive unit (ICU) days, cost avoidance, hospice referrals.PC services within first 48 hours...
Research Article| July 01, 1999 Canyons with undulating walls Ellen E. Wohl; Wohl 1Department of Earth Resources, Colorado State University, Fort Collins, 80523 Search for other works by this author on: GSW Google Scholar Douglas M. Thompson; Thompson Andrew J. Miller 2Department Geography, 1000 Hilltop Circle, University Maryland at Baltimore County, Baltimore, 21250 Author and Article Information Publisher: Geological Society America First Online: 01 Jun 2017 Online ISSN: 1943-2674 Print...