A5065614987- Advanced Welding Techniques Analysis
- Laser Material Processing Techniques
- Aluminum Alloys Composites Properties
- Aluminum Alloy Microstructure Properties
- Signaling Pathways in Disease
- Cardiac Fibrosis and Remodeling
- Adipose Tissue and Metabolism
- Microplastics and Plastic Pollution
- Wireless Body Area Networks
- Muscle Physiology and Disorders
- CAR-T cell therapy research
- Virus-based gene therapy research
- Nanoparticle-Based Drug Delivery
- CRISPR and Genetic Engineering
- Nanoparticles: synthesis and applications
- Viral Infectious Diseases and Gene Expression in Insects
- ATP Synthase and ATPases Research
- Pain Mechanisms and Treatments
- DNA Repair Mechanisms
- Pluripotent Stem Cells Research
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Cardiac Ischemia and Reperfusion
- RNA modifications and cancer
- Mitochondrial Function and Pathology
Southern Medical University
2023-2025
Zhejiang University
2022-2024
Huazhong University of Science and Technology
2015-2024
Chinese Academy of Agricultural Sciences
2024
Hubei University
2021-2024
Quzhou University
2023
Shanghai University
2023
Loughborough University
2023
Southeast University
2023
Zhejiang Province Institute of Architectural Design and Research
2022
AimsOxidative stress contributes to the development of cardiac hypertrophy and heart failure. One mitochondrial sirtuins, Sirt4, is highly expressed in heart, but its function remains unknown. The aim present study was investigate role Sirt4 pathogenesis pathological molecular mechanism by which regulates oxidative stress.
Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart and one for which no efficacious therapies exist. Obesity lipid mishandling greatly contribute to HFpEF. However, molecular mechanism(s) governing metabolic alterations perturbations in homeostasis HFpEF are largely unknown. Here, we report that cardiomyocyte steatosis coupled increases activity transcription factor FoxO1 (Forkhead box protein O1). depletion, as well over-expression Xbp1s (spliced...
Improvement of antitumor effects relies on the development biocompatible nanomaterials and combination various therapies to produce synergistic avoid resistance. In this work, we developed GBD-Fe, a nanoformulation that effectively integrated chemotherapy (CT), chemodynamic therapy (CDT), photothermal (PTT). GBD-Fe used gold nanorods as agents encapsulated doxorubicin amplify Fe3+-guided CDT by producing H2O2 reducing intracellular glutathione levels. vitro in vivo experiments were conducted...
Cardiac hypertrophy is an independent risk factor for heart failure, a leading cause of morbidity and mortality globally. The calcineurin/NFAT (nuclear activated T cells) pathway the MAPK (mitogen-activated protein kinase)/Erk (extracellular signal-regulated kinase) contribute to pathogenesis cardiac as interdependent network signaling cascades. How these pathways interact remains unclear few direct targets responsible prohypertrophic role NFAT have been described.
Pathological cardiac hypertrophy is a major risk factor for heart failure. In this study, we identified interferon regulatory 9 (IRF9), member of the IRF family, as previously unidentified negative regulator hypertrophy. The level IRF9 expression was remarkably elevated in hearts from animals with aortic banding–induced IRF9-deficient mice exhibited pronounced after pressure overload, demonstrated by increased cardiomyocyte size, extensive fibrosis, reduced function, and enhanced markers,...
7xxx series high-strength aluminum alloy joints by friction stir welding (FSW) generally fracture in the heat affected zone (HAZ), i.e. lowest hardness (LHZ) during tensile test. However, experiment results of this study indicate that defect-free FSW 7085-T7452 thick plate weld nugget (WNZ) instead HAZ for whole joint or top slice exhibits very low strength and elongation when using a high rotational rate 600 rpm. Both microstructure characteristics microhardness distribution are not main...
Abstract Precise regulation of mtDNA transcription and oxidative phosphorylation (OXPHOS) is crucial for human health. As a component mitochondrial contact site cristae organizing system (MICOS), Mic60 plays central role in morphology. However, it remains unclear whether affects transcription. Here, we report that interacts with factors TFAM TFB2M. Furthermore, found knockdown compromises OXPHOS activities. Importantly, deficiency decreased binding RNA polymerase (POLRMT) recruitment to the...
Cardiac hypertrophy, a common early symptom of heart failure, is regulated by numerous signaling pathways. Here, we identified tumor necrosis factor receptor-associated 3 (TRAF3), an adaptor protein in factor-related cascades, as key regulator cardiac hypertrophy response to pressure overload. TRAF3 expression was upregulated hypertrophied mice hearts and failing human hearts. Four weeks after aortic banding, cardiac-specific conditional TRAF3-knockout exhibited significantly reduced...
Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells (PSCs) is a central aim in cell regenerative medicine. To date, preferentially reconstituting vivo PSCs remains practical challenge. Here we documented that synergistic transient expression Runx1 Hoxa9 restricted the time window endothelial-to-hematopoietic transition hematopoietic maturation stages PSC differentiation scheme (iR9-PSC) vitro induced preferential generation engraftable progenitors...
Abstract Forkhead box O (FoxO) proteins and thyroid hormone (TH) have well established roles in cardiovascular morphogenesis remodeling. However, specific role(s) of individual FoxO family members stress-induced growth remodeling cardiomyocytes remains unknown. Here, we report that FoxO1, but not FoxO3, activity is essential for reciprocal regulation types II III iodothyronine deiodinases (Dio2 Dio3, respectively), key enzymes involved intracellular TH metabolism. We further show Dio2 a...