A5064289255- Congenital Heart Disease Studies
- Cardiovascular Issues in Pregnancy
- Congenital Diaphragmatic Hernia Studies
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular and Diving-Related Complications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Coronary Artery Anomalies
- Cardiac Arrhythmias and Treatments
- Vascular anomalies and interventions
- Aortic Disease and Treatment Approaches
- Heart Failure Treatment and Management
- Cardiovascular Conditions and Treatments
- Effects of Radiation Exposure
- Pregnancy and preeclampsia studies
- Cardiac tumors and thrombi
- Non-Invasive Vital Sign Monitoring
- Chemotherapy-related skin toxicity
- Nonmelanoma Skin Cancer Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Nutrition, Genetics, and Disease
- Infective Endocarditis Diagnosis and Management
- Signaling Pathways in Disease
- Respiratory viral infections research
Johns Hopkins All Children's Hospital
2011-2024
Johns Hopkins University
2011-2024
Hospital for Sick Children
2024
Grace (United States)
2015-2023
Children's National
2019
Cardinal Glennon Children’s Medical Center
2007-2018
Saint Louis University
2007-2018
University of Utah
2015
Boston Children's Hospital
2015
Primary Children's Hospital
2015
Ebstein anomaly and tricuspid valve dysplasia are rare congenital malformations associated with high perinatal mortality. The literature consists of small, single-center case series spanning several decades. We performed a multicenter study to assess the outcomes factors mortality after fetal diagnosis in current era.Fetuses diagnosed from 2005 2011 were included 23 centers. primary outcome was mortality, defined as demise or death before neonatal discharge. Of 243 fetuses at mean...
Prenatal detection (PND) has benefits for infants with hypoplastic left heart syndrome (HLHS) and transposition of the great arteries (TGA), but associations between sociodemographic geographic factors PND have not been sufficiently explored. This study evaluated whether socioeconomic quartile (SEQ), public insurance, race ethnicity, rural residence, distance residence (distance driving time from a cardiac surgical center) are associated or timing PND, secondary aim to analyze differences...
Background In a recent multicenter study of perinatal outcome in fetuses with Ebstein anomaly or tricuspid valve dysplasia, we found that one third live-born patients died before hospital discharge. We sought to further describe postnatal management strategies and define risk factors for neonatal mortality circulatory at Methods Results This 23-center, retrospective from 2005 2011 included 243 dysplasia. Among patients, clinical echocardiographic were evaluated association palliated versus...
ace and ethnicity, socioeconomic status (SES), geography have been associated with differential outcomes in congenital heart disease death.In patients hypoplastic left syndrome (HLHS), lower SES has increased complications 1-year survival. 1o previous study examined how sociodemographics affect neonatal death among prenatally diagnosed HLHS.The goal was to investigate infants a prenatal diagnosis of HLHS understand associations between maternal patient characteristics hospital discharge...
INTRODUCTION Traumatic brain injury (TBI) is a major cause of neuroendocrine dysfunction, primarily affecting the hypothalamic-pituitary axis. Hypopituitarism, particularly involving growth hormone, gonadotropins, ACTH, and TSH deficiencies, frequently observed in TBI survivors. The underlying pathophysiology includes direct mechanical damage, vascular compromise, neuroinflammatory processes that impair hormone secretion. Despite its significant impact on metabolism, cognition, overall...
IntroductionChronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide, characterized by persistent respiratory symptoms airflow limitation. Despite extensive research, its progressive nature systemic complications continue to challenge clinicians globally. This review explores recent developments in COPD management, including pharmacological advances, non-pharmacological strategies, emerging technologies. Objective: The objective this narrative...
Introduction: Radiation dermatitis represents a prevalent and often underestimated complication of oncologic radiotherapy, particularly in patients undergoing treatment for breast, head neck, pelvic cancers. It encompasses spectrum acute chronic skin changes resulting from ionizing radiation exposure. Understanding the clinical pathophysiological mechanisms is essential effective prevention management. Objective: The primary objective this review to synthesize latest evidence on...
Introduction: Tinnitus is a prevalent auditory disorder characterized by the perception of sound in absence external stimuli. While often associated with cochlear pathology, increasing evidence highlights central nervous system’s role its genesis and persistence. This neurological component has critical implications for understanding treating condition. Objective: review aims to analyze pathophysiological mechanisms underlying tinnitus evaluate current therapeutic approaches targeting...
Abstract Pulmonary hypertension (PH) is a significant health problem that contributes to high morbidity and mortality in diverse cardiac, pulmonary, systemic diseases children. Evidence‐based advances PH care have been challenged by paucity of quality endpoints for assessing clinical course the lack robust trial data guide pharmacologic therapies While landmark adult AMBITION demonstrated benefit up‐front combination therapy with ambrisentan tadalafil, it remains unknown whether upfront...
Predicting outcomes of foetuses with Ebstein's anomaly and tricuspid valve dysplasia continues to be challenging. Limited data exist on the prognostic significance prenatal haemodynamic functional parameters in this population. Our aim was investigate ventricular addition associated morphometric patients anomaly. We reviewed medical records at All Children's Hospital Johns Hopkins Medicine University between 2005 2012. The main outcome survival past 30 days from birth; participants who died...
Abstract Children with a secundum atrial septal defect are usually asymptomatic and referred for elective closure after 3–4 years of age; however, in premature infants chronic lung disease, bronchopulmonary dysplasia, or pulmonary hypertension, increased blood flow secondary to left-to-right shunt, may exacerbate their condition. Closure the these patients can result significant clinical improvement. We report cases two who underwent Gore HELEX Septal Occluder discuss technical aspects using...