Stephanie S. Handler

ORCID: 0000-0002-4114-599X
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About
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Research Areas
  • Congenital Heart Disease Studies
  • Pulmonary Hypertension Research and Treatments
  • Mechanical Circulatory Support Devices
  • Cardiovascular Issues in Pregnancy
  • Cardiac Valve Diseases and Treatments
  • Cardiovascular Function and Risk Factors
  • Kawasaki Disease and Coronary Complications
  • Heart Failure Treatment and Management
  • Coronary Artery Anomalies
  • Innovations in Medical Education
  • Cardiac Structural Anomalies and Repair
  • Neonatal Respiratory Health Research
  • Cardiac Arrhythmias and Treatments
  • Simulation-Based Education in Healthcare
  • Aortic Disease and Treatment Approaches
  • Medical Imaging and Pathology Studies
  • Cardiac Arrest and Resuscitation
  • Vascular anomalies and interventions
  • Long-Term Effects of COVID-19
  • Cardiomyopathy and Myosin Studies
  • Congenital Diaphragmatic Hernia Studies
  • Anatomy and Medical Technology
  • Nitric Oxide and Endothelin Effects
  • Child and Adolescent Health
  • Renal and related cancers

Medical College of Wisconsin
2018-2025

Children's Hospital of Wisconsin
2017-2025

Marquette University
2023

Stanford University
2017

Abstract The Norwood procedure creates a reconstructed neo-aorta to provide unobstructed systemic cardiac output (CO) for Hypoplastic Left Heart Syndrome (HLHS) patients. We used patient-specific computational fluid dynamics (CFD) simulations incorporating physiologic boundary conditions quantify hemodynamics aortic arch geometries versus native arches from control group of single ventricle hypothesized that patients (n=5) would experience significant differences in time-averaged wall shear...

10.1115/1.4068009 article EN Journal of Biomechanical Engineering 2025-02-24
Rachel S. Gross Tanayott Thaweethai Erika B. Rosenzweig James Chan Lori B. Chibnik and 95 more Mine S. Cicek Amy Elliott Valerie J. Flaherman Andrea S. Foulkes Margot Gage Witvliet Richard Gallagher Maria Laura Gennaro Terry L. Jernigan Elizabeth W. Karlson Stuart D. Katz Patricia A. Kinser Lawrence C. Kleinman Michelle F. Lamendola-Essel Joshua D. Milner Sindhu Mohandas Praveen C. Mudumbi Jane W. Newburger Kyung E. Rhee Amy L. Salisbury Jessica Snowden Cheryl R. Stein Melissa S. Stockwell Kelan G. Tantisira Moriah E. Thomason Dongngan T. Truong David Warburton John C. Wood Shifa Ahmed Almary Akerlundh Akram N. Alshawabkeh Brett R. Anderson Judy L. Aschner Andrew M. Atz Robin L. Aupperle Fiona C. Baker Venkataraman Balaraman Dithi Banerjee Deanna M. Barch Arielle Baskin–Sommers Sultana Bhuiyan Marie‐Abèle Bind Amanda Bogie Tamara T. Bradford Natalie C. Buchbinder Elliott Bueler Hülya Bükülmez B.J. Casey Linda Chang Maryanne Chrisant Duncan B. Clark Rebecca G. Clifton Katharine N. Clouser Lesley Cottrell Kelly Cowan Viren D’Sa Mirella Dapretto Soham Dasgupta Walter Dehority Audrey Dionne Kirsten B. Dummer Matthew D. Elias Shari Esquenazi‐Karonika Danielle N. Evans E. Vincent S. Faustino Alexander G. Fiks Daniel Forsha John J. Foxe Naomi P. Friedman Greta Fry Sunanda Gaur Dylan G. Gee Kevin M. Gray Stephanie S. Handler Ashraf S. Harahsheh Keren Hasbani Andrew C. Heath Camden L. Hebson Mary M. Heitzeg Christina M. Hester Sophia Hill Laura Hobart‐Porter Travis K.F. Hong Carol R. Horowitz Daniel S. Hsia Matthew J. Huentelman Kathy D. Hummel Katherine Irby Joanna Jacobus Vanessa L. Jacoby Pei‐Ni Jone David C. Kaelber Tyler Kasmarcak Matthew J. Kluko Jessica S. Kosut Angela R. Laird

Importance The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae SARS-CoV-2 [PASC] or “Long COVID”) in children young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, potential treatment targets adults. Observations We describe protocol for Pediatric Observational Cohort Study NIH’s RE searching COV ID E nhance R ecovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta-cohort study caregiver-child...

10.1371/journal.pone.0285635 article EN cc-by PLoS ONE 2024-05-07

Hypoplastic left heart syndrome (HLHS) is a severe congenital disease (CHD) with complex genetic inheritance. HLHS segregates other ventricular outflow tract (LVOT) malformations in families, and can present as either an isolated phenotype or feature of larger disorder. The multifactorial etiology makes it difficult to interpret the clinical significance variants. Specific genes have been implicated HLHS, including rare, predicted damaging MYH6 variants that are >10% patients, which shown...

10.3390/jcdd9050144 article EN cc-by Journal of Cardiovascular Development and Disease 2022-05-03

10.1016/j.ahj.2021.08.003 article EN publisher-specific-oa American Heart Journal 2021-08-19
Matthew D. Elias Dongngan T. Truong Matthew E. Oster Felicia Trachtenberg Xiangyu Mu and 95 more Pei‐Ni Jone Elizabeth Mitchell Kirsten B. Dummer S. Kristen Sexson Tejtel Onyekachukwu Osakwe Deepika Thacker Jennifer Su Tamara T. Bradford Kristin M. Burns Michael J. Campbell Thomas J. Connors Laura D’Addese Daniel Forsha Olivia Frosch Therese M. Giglia Lauren Goodell Stephanie S. Handler Keren Hasbani Camden L. Hebson Anita Krishnan Sean M. Lang Brian W. McCrindle Kimberly E. McHugh Lerraughn M. Morgan R. Mark Payne Arash Sabati Eyal Sagiv Yamuna Sanil Faridis Serrano Jane W. Newburger Audrey Dionne Gail D. Pearson Victoria L. Pemberton D’Andrea Egerson Lynn Mahony Julie Ann Miller Kerri Hayes Allison Crosby‐Thompson Ayesha Amarnath James Ambrosoli Cassandra Artis Kay Rubio Chitra Kinhikar Amanda Marshall Devine Mbiydzenyuy Valentina Kazlova Chenwei Hu Lozan Eyob Beverly Slayton Lauren DiStefano Jami Honig Tiffany Bowie Rob Nero Emily Birmingham Robin Rowe Melissa Joyce Cole Gallagher Djenawa Bowman Mo Zhang Alissa Mooney Andréea Dragulescu Christopher Wai Kei Lam Rae S. M. Yeung Beth Gamulka Jessica Bainton Martha Rolland Patti Walter Simran Mahanta Thomas Giorgio Numaira Khan Annette Baker Lisa Jean Buckley Jessica Jones LaTina Watson Anna Clarke Tor-Samuel-Aleer Leek Gwendolyn Orav Tonia Morrison Katherine Lupton Donna Sylvester Dana Albizem Kristin Lanzilotta Grace Marks Madison Johnson Megan M. Bickford Linda M. Lambert Lilly Fagatele Andrea Curless Mark W. Russell Tammy Doman Marisa Almaguer Lauryn Dugan Kathleen Rathge Elle Seibert Mary Stumpf

Importance Data are limited regarding adverse reactions after COVID-19 vaccination in patients with a history of multisystem inflammatory syndrome children (MIS-C). The lack vaccine safety data this unique population may cause hesitancy and concern for many families health care professionals. Objective To describe following MIS-C. Design, Setting, Participants In multicenter cross-sectional study including 22 North American centers participating National Heart, Lung, Blood Institute,...

10.1001/jamanetworkopen.2022.48987 article EN cc-by-nc-nd JAMA Network Open 2023-01-03

ABSTRACT Pulmonary arterial endothelial and smooth muscle cell homeostasis is regulated through the bone morphogenetic protein (BMP) transforming growth factor beta (TGF‐β) receptor pathways. Pathway imbalance results in pulmonary hypertension (PH). Each pathway has ligands modulators influencing this balance. How these pathways differ pediatric PH patients unknown. Ten 20 control subjects (ages 2–17 years) were prospectively enrolled. artery serum BMP 2, 4, 6, 7, 9, 10, activin A, TGF‐β1,...

10.1002/pul2.70068 article EN cc-by-nc Pulmonary Circulation 2025-04-01

Rationale: Hemodynamic assessments direct care among children with pulmonary hypertension, yet the use of cardiac catheterization is highly variable, which could impact patient and research. Objectives: We analyzed hemodynamic findings from right heart (RHC) left acute vasodilator testing (AVT) safety in World Symposium on Pulmonary Hypertension (WSPH) group 1 3 subtypes a large multicenter North American cohort. Methods: Of 1,475 enrolled Pediatric Network Registry (2014–2020), there were...

10.1513/annalsats.202108-998oc article EN Annals of the American Thoracic Society 2022-01-20

Abstract Pulmonary hypertension (PH) is a significant health problem that contributes to high morbidity and mortality in diverse cardiac, pulmonary, systemic diseases children. Evidence‐based advances PH care have been challenged by paucity of quality endpoints for assessing clinical course the lack robust trial data guide pharmacologic therapies While landmark adult AMBITION demonstrated benefit up‐front combination therapy with ambrisentan tadalafil, it remains unknown whether upfront...

10.1002/pul2.12305 article EN cc-by-nc Pulmonary Circulation 2023-10-01

Abstract Pulmonary vasodilator treatment can improve hemodynamics, right ventricular function, symptoms, and survival in pediatric pulmonary hypertension (PH). However, clinical trial data are lacking due to many constraints. One major limitation is the lack of relevant endpoints reflective hemodynamics or functional status patients whom standard exercise testing impractical, unreliable, not reproducible. The Kids Mod PAH (Mono‐ vs. Duo Therapy for Pediatric Arterial Hypertension) an ongoing...

10.1002/pul2.12339 article EN cc-by-nc Pulmonary Circulation 2024-01-01

Virtual reality has emerged as a unique educational modality for medical trainees. However, incorporation of virtual curricula into formal training programmes been limited. We describe multi-centre effort to develop, implement, and evaluate the efficacy curriculum residents participating in paediatric cardiology rotations.A software program ("The Stanford Heart") was utilised. Users are placed "inside heart" explore non-traditional views cardiac anatomy. Modules six common congenital heart...

10.1017/s1047951122000890 article EN Cardiology in the Young 2022-04-25

Abstracts Because of remarkable advances in survival over the past 40 years, worldwide population individuals with single ventricle heart disease living Fontan circulation has grown to ≈70 000, nearly half aged >18 years. Survival at least 30 years age is now achievable for 75% patients. On other hand, patients account largest group 6000 8000 children hospitalized failure, or without failure annually United States, highest in‐hospital mortality. there little understanding underlying...

10.1161/jaha.119.015871 article EN cc-by-nc-nd Journal of the American Heart Association 2020-03-19

The aim of this study is to evaluate quality life in four domains (physical, emotional, social, and school) pediatric patients with pulmonary hypertension (PH) using a validated survey (PedsQL). This prospective cohort aged 2-18 years PH. Parents all children 8-18 appropriate developmental capacity completed the PedsQL clinic. Results were compared published norms for patients, those congenital heart disease (CHD) cancer. Thirty-three enrolled yielding 32 parent 18 patient self-reports:...

10.1177/2045894018822985 article EN cc-by-nc Pulmonary Circulation 2018-12-18

The aim of this study was to determine practice patterns and inter‐institutional variability in how acute vasoreactivity testing (AVT) is performed interpreted pediatrics throughout the world. A survey offered physicians affiliated with Pediatric & Congenital Heart Disease Taskforce Pulmonary Vascular Research Institute (PVRI), Hypertension Network (PPHNET), or Spanish Registry for (REHIPED), from February December 2016. requested data about site‐specific protocol AVT subsequent...

10.1177/2045894019857533 article EN cc-by-nc Pulmonary Circulation 2019-05-30

In the SVR (Single Ventricle Reconstruction) Trial, 1-year survival in recipients of right ventricle to pulmonary artery shunts (RVPAS) was superior that those receiving modified Blalock-Taussig-Thomas (MBTTS), but not subsequent follow-up. Cost analysis is an expedient means evaluating value and morbidity.

10.1016/j.jacadv.2022.100029 article EN cc-by-nc-nd JACC Advances 2022-05-26
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