A5051862719- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Mechanical Circulatory Support Devices
- Cardiovascular Issues in Pregnancy
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Kawasaki Disease and Coronary Complications
- Heart Failure Treatment and Management
- Coronary Artery Anomalies
- Innovations in Medical Education
- Cardiac Structural Anomalies and Repair
- Neonatal Respiratory Health Research
- Cardiac Arrhythmias and Treatments
- Simulation-Based Education in Healthcare
- Aortic Disease and Treatment Approaches
- Medical Imaging and Pathology Studies
- Cardiac Arrest and Resuscitation
- Vascular anomalies and interventions
- Long-Term Effects of COVID-19
- Cardiomyopathy and Myosin Studies
- Congenital Diaphragmatic Hernia Studies
- Anatomy and Medical Technology
- Nitric Oxide and Endothelin Effects
- Child and Adolescent Health
- Renal and related cancers
Medical College of Wisconsin
2018-2025
Children's Hospital of Wisconsin
2017-2025
Marquette University
2023
Stanford University
2017
Abstract The Norwood procedure creates a reconstructed neo-aorta to provide unobstructed systemic cardiac output (CO) for Hypoplastic Left Heart Syndrome (HLHS) patients. We used patient-specific computational fluid dynamics (CFD) simulations incorporating physiologic boundary conditions quantify hemodynamics aortic arch geometries versus native arches from control group of single ventricle hypothesized that patients (n=5) would experience significant differences in time-averaged wall shear...
Importance The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae SARS-CoV-2 [PASC] or “Long COVID”) in children young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, potential treatment targets adults. Observations We describe protocol for Pediatric Observational Cohort Study NIH’s RE searching COV ID E nhance R ecovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta-cohort study caregiver-child...
Importance Data are limited regarding adverse reactions after COVID-19 vaccination in patients with a history of multisystem inflammatory syndrome children (MIS-C). The lack vaccine safety data this unique population may cause hesitancy and concern for many families health care professionals. Objective To describe following MIS-C. Design, Setting, Participants In multicenter cross-sectional study including 22 North American centers participating National Heart, Lung, Blood Institute,...
Hypoplastic left heart syndrome (HLHS) is a severe congenital disease (CHD) with complex genetic inheritance. HLHS segregates other ventricular outflow tract (LVOT) malformations in families, and can present as either an isolated phenotype or feature of larger disorder. The multifactorial etiology makes it difficult to interpret the clinical significance variants. Specific genes have been implicated HLHS, including rare, predicted damaging MYH6 variants that are >10% patients, which shown...
ABSTRACT Pulmonary arterial endothelial and smooth muscle cell homeostasis is regulated through the bone morphogenetic protein (BMP) transforming growth factor beta (TGF‐β) receptor pathways. Pathway imbalance results in pulmonary hypertension (PH). Each pathway has ligands modulators influencing this balance. How these pathways differ pediatric PH patients unknown. Ten 20 control subjects (ages 2–17 years) were prospectively enrolled. artery serum BMP 2, 4, 6, 7, 9, 10, activin A, TGF‐β1,...
Rationale: Hemodynamic assessments direct care among children with pulmonary hypertension, yet the use of cardiac catheterization is highly variable, which could impact patient and research. Objectives: We analyzed hemodynamic findings from right heart (RHC) left acute vasodilator testing (AVT) safety in World Symposium on Pulmonary Hypertension (WSPH) group 1 3 subtypes a large multicenter North American cohort. Methods: Of 1,475 enrolled Pediatric Network Registry (2014–2020), there were...
Abstract Pulmonary hypertension (PH) is a significant health problem that contributes to high morbidity and mortality in diverse cardiac, pulmonary, systemic diseases children. Evidence‐based advances PH care have been challenged by paucity of quality endpoints for assessing clinical course the lack robust trial data guide pharmacologic therapies While landmark adult AMBITION demonstrated benefit up‐front combination therapy with ambrisentan tadalafil, it remains unknown whether upfront...
Abstract Pulmonary vasodilator treatment can improve hemodynamics, right ventricular function, symptoms, and survival in pediatric pulmonary hypertension (PH). However, clinical trial data are lacking due to many constraints. One major limitation is the lack of relevant endpoints reflective hemodynamics or functional status patients whom standard exercise testing impractical, unreliable, not reproducible. The Kids Mod PAH (Mono‐ vs. Duo Therapy for Pediatric Arterial Hypertension) an ongoing...
Virtual reality has emerged as a unique educational modality for medical trainees. However, incorporation of virtual curricula into formal training programmes been limited. We describe multi-centre effort to develop, implement, and evaluate the efficacy curriculum residents participating in paediatric cardiology rotations.A software program ("The Stanford Heart") was utilised. Users are placed "inside heart" explore non-traditional views cardiac anatomy. Modules six common congenital heart...
Abstracts Because of remarkable advances in survival over the past 40 years, worldwide population individuals with single ventricle heart disease living Fontan circulation has grown to ≈70 000, nearly half aged >18 years. Survival at least 30 years age is now achievable for 75% patients. On other hand, patients account largest group 6000 8000 children hospitalized failure, or without failure annually United States, highest in‐hospital mortality. there little understanding underlying...
The aim of this study is to evaluate quality life in four domains (physical, emotional, social, and school) pediatric patients with pulmonary hypertension (PH) using a validated survey (PedsQL). This prospective cohort aged 2-18 years PH. Parents all children 8-18 appropriate developmental capacity completed the PedsQL clinic. Results were compared published norms for patients, those congenital heart disease (CHD) cancer. Thirty-three enrolled yielding 32 parent 18 patient self-reports:...
The aim of this study was to determine practice patterns and inter‐institutional variability in how acute vasoreactivity testing (AVT) is performed interpreted pediatrics throughout the world. A survey offered physicians affiliated with Pediatric & Congenital Heart Disease Taskforce Pulmonary Vascular Research Institute (PVRI), Hypertension Network (PPHNET), or Spanish Registry for (REHIPED), from February December 2016. requested data about site‐specific protocol AVT subsequent...
In the SVR (Single Ventricle Reconstruction) Trial, 1-year survival in recipients of right ventricle to pulmonary artery shunts (RVPAS) was superior that those receiving modified Blalock-Taussig-Thomas (MBTTS), but not subsequent follow-up. Cost analysis is an expedient means evaluating value and morbidity.
Abstract Background: There are several published echo-derived scores to help predict successful biventricular versus univentricular palliation in neonates with critical aortic stenosis. This study aims determine whether any scoring system accurately predicted outcomes these neonates. Methods: Single centre, retrospective cohort including who underwent valve intervention (surgical valvotomy or balloon valvuloplasty) the intention of circulation. Primary outcome was survival circulation at...